I-Depakote i-Sprinkles kunye nezinye iifom zeValproate
UValproate yiyilisi echazwe njengamayeza e-anticonvulsant kwaye ke ngoko imiselwe ukuba ilawulwe. Kuye kwabekwa ngamanye amaxesha ukukhusela i-migraine ikhanda kunye nokunciphisa iziqulatho zomntu kwi-disorder bipolar. Abanye oogqirha banamisela ukuba baphathe iimpawu ezicelomngeni kwisifo se-Alzheimer kunye nezinye iintlobo zesifo sengqondo .
Ukusebenzisa i-valproate ngale ndlela kuthathwa njenge -label- njengoko ingavunywanga yi-US Food and Drug Administration (FDA) kule nkqubo.
Iimveliso zeValproate ziquka i-valproate sodium (Depacon), i-divalproex sodium (i-Depakote, i-Depakote CP kunye ne-Depakote ER), i-valproic acid (i-Depakene ne-Stavzor), kunye ne-generic yabo, "ngokwe-FDA.
Iifom ezahlukeneyo zeValproate
UValproate uvela kwiifom ezahlukeneyo, kubandakanya iipilisi, iipilisi ezikhululwayo, iifomsules ezine-valproate sprinkles (ezi khonkwane zingagxinwa ngokupheleleyo okanye zivulwe kwaye iziqulatho zifafazwe ekutya okuncinci kulabo abanenkinga yokugwinya) kunye neenjini / iiVs kubantu abangenako ukuthatha imithi yomlomo.
Kutheni i-Valproate isetyenzisiwe ukujongana nezixhobo ezinzima kwi-Dementia?
Enye yeengxaki kwi-Alzheimer's disease kukuba ubuntu kunye nokuziphatha kunokutshintsha ngenxa yesifo. Ezinye zeempembelelo ezicelomngeni zengqondo ye-dementia zinokuquka ukuphazamiseka , ukungazinzi, ukudibanisa , ukunyanzela izityholo , ukunyamekela ukunyamekela, ukuzulazula nokucinga .
Kungaba nzima ukwazi indlela yokuphendula kwezi ntlobo zokuziphatha kunye neemvakalelo.
Uluntu lwezonyango luye lwazama iziyobisi ezahlukahlukeneyo ukuzama ukunciphisa ezi ziphathayo, kubandakanywa nemithi ye-antipsychotic (leyo ingaba nemiphumo emibi embi kwaye ilawulwa kakhulu kwi-home nursing industry), i-benzodiazepines (ezayo neempembelelo ezimbi kunye nokusebenza okungaqinisekiyo) kunye izidandlululo ( ezingasoloko zisebenza okanye zifanelekileyo).
Umgca wecala kukuba ngokuqhelekileyo ayinayo imishanguzo ephumelelayo ukuphatha ukuphazamiseka kokuziphatha ekudemeni kwengqondo .
Ngaloo ndlela, i-valproate yavuka njengomzabalazo ekuzameni ukuphazamiseka kwengqondo. Ukongeza kwithemba lokuba yinkqubo ephumelelayo, i-valproate yayinomdla wokuba yipilisi eyayihamba ngeyona nto ngaphantsi kwe-radar ngokwemimiselo yekhaya lononophala-ejoliswe kakhulu ekunciphiseni nasekupheliseni imishanguzo ye-antipsychotic ukuphazamiseka kwengqondo kodwa kungekhona njengoko kugxile kwi-valproate.
Ngaba iValproate kufuneka isetyenziswe ukujongana neengxaki ezinzima kwi-Dementia?
Ngokwezifundo ezininzi zophando, impendulo ngokubanzi kukuba:
Ngoba kutheni?
Ngokuqhelekileyo ayisebenzi. Nangona kukho iziganeko ezizimeleyo zokuphumelela, ukuphononongwa kwezifundo ezininzi kugqiba ukuba i-valproate ayiluncedo kunokuba i-placebo (ipilisi yefake) ekunciphiseni iimpawu ezicelomngeni zengqondo.
Ngokomnye uphando olushicilelwe kwi- JAMA Psychiatry , i-valproate nayo yahluleka ukunciphisa ukuqhubeka kwengqondo kwengqondo, inzuzo ethembekileyo engazange ivele ngokusetyenziswa kwayo.
Imiphumela
Izifundo ezininzi ziye zafumanisa ukuba abathathi-nxaxheba abafumene i-valproate babengozibeka emngciphekweni omkhulu kwimiphumo emibi evela kumachiza.
Ezi ziphumo zecala ziquka i- thrombocytopenia (iyancipha iiplatelet zegazi), ukwanda okukhulu, ukuphazamiseka kwintlungu, ukuyikrakra, ukudibanisa nokulala, ukuncwina, ukuhlanza kunye nohudo.
Eminye iValproate
Esikhundleni sokufikelela kwiibhotile zonyango ukuguqula iimpawu ezinzima kwi-dementia, isicwangciso sokuqala kufuneka sihlale sisisigxina . Cinga izinto ezinokubangela ezo ziphathekayo ezifana nokusingqongileyo , intlungu yomzimba , ukungahambi kakuhle okanye ukungazinzi kwaye uzame ukulungisa nokulungelelanisa izizathu ezinokubangela.
Sebenzisa amaqhinga afana nokuvumela umntu ixesha elithile ukuba azinqabise yodwa kwaye abuyele kamva ukugqiba umsebenzi ozama ukuwufeza.
Ekugqibeleni, qaphela ukuba ukunyamezela nokukhathazeka kunokunyusa ukuziphatha komntu onomdemokhrasi. Zihlolisise iimpawu zomnakekeli ogqithiseleyo kwaye usebenzise intsapho, abahlobo kunye nezibonelelo zoluntu ukuxhasa ngenkqubela yakho.
ILizwi
Kuqhelekileyo kwaye kulungile ukufuna unyango olunceda ekuziphatheni okunzima okuvame ukukhula komqondo. Ngelishwa, asikafumani unyango okhuselekileyo kunye osebenzayo kule njongo.
Ngenxa yoko, qiniseka ukuba ufuna inkxaso njengomncedisi ngenxa yokuba iimpawu zokuziphatha nezengqondo zesifo sengqondo somzimba zingabangela uxinzelelo. Le nkxaso inokukunceda uzive ungenanto kwaye uvumele abancinci ukuba babelane ngezicwangciso ezahlukeneyo eziye zaba luncedo kubo.
> Imithombo:
> ClinicalTrials.gov. Valproate kwi-Dementia (VALID). Julayi 6, 2010.
> Idatha yeCchrane yeeNkqubo eziPhezulu. 2009 Julayi 8; (3). I-Valproate Ukulungiselela Ukuguquka kwi-Dementia.
> Depakote. Depakote Formulations.
> JAMA Psychiatry. I-Divalproex Isifo esingapheliyo soMoya wokuThuthukisa ukuThuthukiswa nokuThuthukiswa kweZifo ze-Alzheimer.
> Umgulane wezeMpilo yengqondo. 2012; 1 (11): 14. Ukunyulwa kweValproate kwisiXeko esineendoda ezikhulile nge-Dementia: Ukuvavanywa kokunqanyulwa kunye nokunciphisa i-Dose.
> Ulawulo lweZiko lokuTya kunye neDrug. Ulwazi lweValproate.
> Williams, L. Bonke Basebenza Ngobungqina: Valproate for Agitation in Dementia.
> Yeh, Y. no-Ouyang, W. (2012). Ukuqiniswa kwemimoya yokunyanga kweempawu zokuziphatha kunye nengqondo yengqondo: Ukuhlaziywa kokuhlaziywa. I-Kaohsiung Journal of Sciences yezoNyango , 28 (4), iphe.185-193.