Ubu bungqina kunye nokuchasene nokuMelana nokuCandwa kweeNkcazo
Izifundo zakuqala zakhokelela kwintsimi ye-dementia malunga nekhonkco ekhoyo phakathi kwezilwanyana ezinciphisa i-cholesterol ezibizwa ngokuba yi- statins kunye nokuthinteka komqondo . Kodwa iiphando zexesha elide azizange zenze izigqibo ezithembisayo.
I-Lancet Study ibonisa Ukunciphisa Umngcipheko we-Dementia
NgoNovemba ka-2000, uphando olupapashwe kwiLancet lubonise ukuba abantu abangaphezu kweminyaka engama-50 abaye bemiselwe ama-statins banomngcipheko omkhulu wokuhlaziya i-dementia .
Abaphandi baqhathanisa abantu abangama-284 abanomdemokhrasi ("amatyala") kunye nama-1,080 "olawulo" abangenalo. Olu hlobo lwesifundo luyaziwa njengoluhlu lokulawulwa kwimeko. Abo bantu ababengummiselo omiselweyo babenomngcipheko ophantsi kakhulu xa kuthelekiswa nalabo abangazange bamiselwe i-statins, nangemva kokuba izinto ezifana nobudala, isini kunye neembali zesifo senhliziyo ziqwalaselwe. Iziphumo zazininzi kakhulu.
Izifundo ezongezelelweyo zichasayo Iingcamango zeNkcazo kunye nokuThinjwa kweDementia
Nangona uphando lwesibini olushicilelwe ngo-2004 lufumene ukuba abasebenzisi be-statin babenomngcipheko ongaphantsi kwe-39% we-Alzheimer's disease xa kuthelekiswa nabasebenzisi ababengabonakaliyo, oko kwakunomxholo wokulawulwa kwimeko. Ngaba ezi zifundo ezimbini zithetha ukuba i-statins iyanciphisa isifo se-Alzheimer's disease? Ngelishwa ayikho.
I- Cochrane Database yeeNkqubo eziPhezulu ziqaphele izifundo ezimbini ezibalulekileyo eziqhutyelwe ekusebenziseni iimimiselo kubantu abasemngciphekweni we-Alzheimer kunye nezinye i-dementias, ezibandakanya inani labali-26,340 abathathi-nxaxheba.
Zizo zombini zilingo ezinokuphinda zilawulwe nge-randomized-random, zolu hlobo oluthile lokufunda. Ngenxa yokuba izifundo zolawulo lweemeko zibukeka emva kwexesha kwaye azange zilandelelaniswe, izigqibo ezingathathwa kuzo zilinganiselwe. Izifundo ezimbini eziyimpumputhe zikhangele phambili ngexesha, zicwangciswe ukuba abaphandi bophando abazi ukuba iziphi izigulana zifumana iziyobisi kwaye zifumana indawo ye-placebo kwaye zilungele kangcono ukubonisa ubudlelwane neziphumo.
Izigulana kwisifundo sokuqala esiphambileyo semibini zalandelwa ukulinganisa iminyaka engama-3.2, kunye nalabo besifundo sesibini iminyaka emihlanu. Umsebenzi oqikelelweyo wabantu ekufundweni kokuqala wenqabileyo ngezinga elifanayo. Kwaye kwiseshoni yesibini, akukho mmahluko kwimeko yesifo sengqondo phakathi kwezifundo ezine-statin ngokumalunga nalabo abanendawo ye-placebo.
Ukunikezelwa kwamandla kwezi zifundo kamva, ubungqina bokugqiba ukuba i-statins ikhusela i-Alzheimer okanye enye i-dementias ngokuqinisekileyo ngeli xesha.
Imithombo:
I-Cochrane Database yeeNkqubo eziPhononongo. Ngo-2016 uJan 4; 1: IiNkcazo zoLungiso lwe-Dementia. http://www.ncbi.nlm.nih.gov/pubmed/26727124.
Jick H, MD, Zornberg GL, MD, Jick SS, DSc, Seshadri S, MD, iDrachman DA, MD. "IiNkcazo kunye noMngcipheko weDementia." ILancet 2000 vol. 356, Issue 9242: 1627-31.
McGuinness B, Craig D, Inkunzi yeB bullock R, Passmore P. "Izitatimende zokuLungela ukuDementia". I-Cochrane Database yeeNkqubo eziPhononongo zika- 2009, iNqaku 2.
UZamrini E, uMcGwin G, uRoseman J. "Umanyano phakathi kweStatin Use and Armheim's's Disease". Neuroepidemiology 2004; 23: 94-98.
-Kuhleliwe ngu-Esther Heerema, MSW