Isifo sikashukela kunye neDementia
Uqhagamshelo lucacile; Abantu abane- type 2 yeswekile abanomngcipheko ophezulu kakhulu wokuphuhlisa isifo se-Alzheimer kunye nezinye iintlobo zesifo sengqondo. Enyanisweni, kukho intambo phakathi kwezi zimbini izifo ezithiwa ngu-Alzheimer's "Type 3 Diabetes " ngabanye.
Nangona kunjalo, uphando olutsha lubonisa ukuba kukho into esinokuyenza malunga nale mngcipheko.
Kwiminyaka emininzi, abaphandi baye bavavanya ukuba kungenzeka ukuba iziyobisi ze-insulin zinokunceda ekuphatheni isifo se-Alzheimer . Ngokomzekelo, uphando oluthile lufumene ubudlelwane phakathi kwonyango kunye ne-insulin yesistim yeziyobisi kunye nesiganeko esincitshisiweyo somqondo wesifo sikashukela kubantu abanesifo sikashukela.
Isifundo
Esinye sezifundo zakutshanje kwi-diabetes kunye nokugula komqondo kugxininise ekunokunciphisa umngcipheko wokuphuhliswa kwengqondo, ngokuchasene nokunyangwa kwimeko emva kokuba iqhube.
Abaphandi baseJamani baphonononga ulwazi lwe-inshorensi yempilo kwizigulane eziyi-145,928 ngaphezu kweminyaka engama-60 kwiminyaka ka-2004-2010. Bahlukanisa abantu ngamaqela ahlukeneyo:
- Ukungabikho kwesifo sikashukela
- Isifo sikashukela ngaphandle kokunyangwa yi-drug pioglitazone
- Ukuxilongwa kwesifo sikashukela esaphathwa yi-pioglitazone yezilwanyana ezingaphantsi kwe-8 kwikota yekhalenda
- Ukuxilongwa kwesifo sikashukela esaphathwa yi-pioglitazone yezilwanyana ezingaphezu kwe-8 kwikota yekhalenda
Emva koko bafanisa umgangatho wokuphuhliswa kwengqondo komzimba kula maqela.
Iziphumo
Emva kokuba idatha iqulunqwe, iziphumo ezilandelayo zifunyenwe:
1) Njengoko kulindelwe kusekelwe kuphando olwangaphambili, umngcipheko ophezulu wokuba nokugula komntu kubantu abanesifo sikashukela kuye kwaqinisekiswa, kwaye ingama-23% yandisa ingozi xa kuthelekiswa nabangenayo i-diabetes.
2) Abantu abanesifo sikashukela abaye baphathwa nge-pioglitazone kwiikota zekhalenda ezingaphezulu kwe-8 babenomngcipheko omkhulu wokuba nomba wokugula kwengqondo.
3) Enyanisweni, umngcipheko we-dementia wawungaphantsi kwalabo abanesifo sikashukela- ngama-47%. Ngamanye amazwi, abantu abanexesha elide lokonyango lwe-pioglitazone bekunomlinganiselo wesigxina somqondo wesifo sengqondo ngokuthelekiswa nabantu abangenayo isifo sikashukela.
4) Abo banexesha elincinci lokunyanga kwe-pioglitazone (ngaphantsi kwekota yekhalenda) babonisa ingozi efana nengqondo yokuxhatshazwa komzimba xa kuthelekiswa nabantu abangenayo i-diabetes.
5) I-Metformin, esinye isidakamizwa esicetywayo ukunyanga isifo sikashukela, safunyanwa nciphisa umngcipheko weengqondo, kodwa kwinqanaba eliphantsi.
Esi siphumo esithakazelisayo sikhombisa ukuba ukusebenzisa i-pioglitazone kunokunciphisa umngcipheko olandelayo we-dementi kubantu abanesifo sikashukela. Uphononongo olwenzelwe ngokukodwa ukuqinisekisa ukuba izidakamizwa ngokwenene zinika le ntlawulo ngoku ifunekayo. Ngethamsanqa, izifundo ezifana nalezi zikhuthaza ngakumbi uphando malunga nolwalamano oluphakathi kwesifo sikashukela kunye nengqondo.
Okunye malunga nePioglitazone
I-Pioglitazone (igama lophawu lwegama elithi Actos) lonyango kwiklasi ye- thiazolidinediones . Kubekiwe ukuba baphathe isifo sikashukela ngokuphucula uvakalelo kwi-insulin.
Nangona iziphumo zolu cwaningo zikhuthaza kakhulu, kukho iinkxalabo ezichongiweyo ngokusetyenziswa kwesi sinyango kubandakanya ukungaphumeleli kwintliziyo yesibindi, iingxaki zesibindi, umhlaza wesisu kunye nomngcipheko wokwanda kwamathambo.
Uphando oluqhubekayo
Uphando olungakumbi luqhutyelwa ekusebenziseni la mayeza kunyango kunye nokuthintela ukugula komqondo. Ukutyelela i-US Clinical Trials ukujonga iimvavanyo zekliniki eziqhubekayo ezibandakanya i-pioglitazone.
Imithombo:
Annals of Neurology. 2015 ngoMeyi 14. Impembelelo yonyango lwe-pioglitazone kwiziganeko zokugula komzimba. http://www.ncbi.nlm.nih.gov/pubmed/25974006
I-Deutsches Zentrum ye-Neurodegenerative Erkrankungen eV Isiko saseJamani se-Neurodegenerative Diseases ngaphakathi kwe-Association ye-Helmholtz. Isifo seswekile sisinciphisa umngcipheko weengqondo. Kufumaneke ngo-Juni 25, 2015.https: //www.dzne.de/en/about-us/public-relations/meldungen/2015/press-release-no-8.html
AmaZiko eZiko lezeMpilo. ILayibrari yeSizwe ka-US yamayeza. Medline Plus. Pioglitazone. NgoFebruwari 15, 2014. http://www.nlm.nih.gov/medlineplus/druginfo/meds/a699016.html