Isifo se-Alzheimer uhlobo lwengqondo eqhubekayo echaphazela abantu abangaphezu kwezigidi ezingama-5 baseMerika, kwaye ezo zorhafu ziyacetyiswa ukuba zandiswe ngokukhawuleza kwiminyaka emininzi elandelayo. Omnye uqhagamshela kwisifo se-Alzheimer abaphandi abahlola ngayo isifo sikashukela. Kukho izifundo eziliqela eziye zadibanisa izifo zombini kunye. Enyanisweni, abanye abaphandi baye baqala ukubiza isifo se-Alzheimer "uhlobo lwesifo sikashukela."
Nangona uphando oluncinci lufumene umngcipheko ophezulu wengozi yokugula ngengqondo yesifo sikashukela, ininzi yesifundo sesigqirha saphetha ukuba le nxu lumano phakathi kwesifo sikashukela kunye ne-Alzheimer sichaza i-ype 2 yeswekile .
Uhlobo lwe-2 lwesifo sikashukela luyaqala xa i-insulin iba yincinci ekusebenziseni iswekile ngokusebenzisa igazi. Izifundo zibonisa ukuba malunga nesiqingatha sabantu abanesifo sikashukela se-2 baya kuqhubela isifo se-Alzheimer. Ngokuxhamla okunzulu okunjalo, ukujoliswa kwezinto ezithile zophando kukuchaza ukudibanisa phakathi kwezi zibini zifo.
Uhlobo lwesithathu sikashukela
Kulo hlobo 1 okanye 2 lweswekile, akwanele ngokwaneleyo i-insulin (okanye akukho nanye) ikhiqizwa ekusebenzeni i-glucose (iswekile) ngokufanelekileyo okanye umzimba awusaphenduli kwi-insulin, kwaye ichaphazela ukusebenza kuwo wonke umzimba. Kwi-Alzheimer's disease, kubonakala ngathi kukho ingxaki efanayo, kodwa endaweni yokubangela iingxaki kumsebenzi wonke umzimba, iziphumo zenzeka kwingqondo.
Abaphandi bafumanisa ubungqina obunomdla obu bakala xa befunda ubuchopho babantu emva kokufa kwabo. Baqaphele ukuba ubuchopho balabo abane-Alzheimer's disease abangenayo uhlobo 1 okanye uhlobo lwesifo sikashukela 2 lubonisa ubuninzi obufanayo kunye nabasifo sikashukela, kubandakanywa amanqanaba amancinci e-insulin engqondweni.
Oku kwabangela abaphandi ukuba bagqibe ukuba mhlawumbi i-Alzheimer iyinxalenye yesifo sikashukela esichaza "uhlobo lwesifo sikashukela."
Kwi-diabetes, ukuba isifo somntu wesifo sikashukela siphezulu kakhulu okanye siphantsi kakhulu, umzimba uthumela iimpawu ezicacileyo zengxaki: ukuguquka kokuziphatha, ukudideka, ukuthinteka, njl. Esi sifo se-Alzheimer, nangona kunjalo, kunokuba ezo zibonakaliso ezinzima zengxaki, Umsebenzi wengqondo kunye nesakhiwo sinciphisa kancane kancane ngexesha.
Xa iqela labaphandi lihlolisisa ukuqokelela kweengxaki ezikhoyo kwisifo se-Alzheimer kunye nomsebenzi wengqondo, baqaphele ukuba ukufumana okufanayo kwisifo se-Alzheimer kukudakalisa ubuchopho bokukwazi ukusebenzisa nokusetyenziswa kwe-glucose. Baqhathanisa ukuhla kwekhono lokuqonda kunye nokuqonda ukuba ukuhla kwe-glucose processing ihambelana, okanye kwandulela ngaphambili, ukunciphisa ingqondo yokukhubazeka , ukufumanisa amagama , ukuguquka kokuziphatha kunye nokunye.
Ngaphezu koko, izazinzulu zenza ukuba njengokuba i-insulin isebenza engqondweni, i-brain is cognitive ability to decrease, ubukhulu kunye nesakhiwo sobuchopho buya kuncipha-zonke izinto ezenzeka njenge-Alzheimer's disease.
Ngaba Uhlobo lweSibini lwesifo sikashukela lubangela izifo ze-Alzheimer?
Uphando luqhubeka malunga nalo mbuzo, kodwa olunye uphando lubonisa ukuba nangona isifo sikashukela sinokukhula kwaye sinegalelo ekuphuhlisweni kwesifo se-Alzheimer, mhlawumbi asiyiyo yimbangela yayo.
Kule sifundo, izazinzulu zondla iigundane zokutya eziphezulu ezidityanisiweyo ezenza ukuba kuphuhliswe uhlobo lwesifo sikashukela. Emva koko bafunda iigundane bafumanisa ukuba iprotheni ephakamileyo ye-tau yayikho kwiibhokhwe zabo, kwaye iigundane nazo zaba ne-resistance to brain insulin. Ukongezelela, isakhiwo sobuchopho bala manxeba saye sahlaselwa kwindlela ethile yokutya okuninzi; nangona kunjalo, ukusebenza okuqondayo kwezi mpawu akuzange kunqabile kakhulu kwizinga abaya kuba nalo xa isifo se-Alzheimer sisekhona.
Ukukhangela kwizinto ezibangelwa zizifo ze-Alzheimer's
Ngoko, yintoni eyenza i-Alzheimer if idilesi yesibini i-diabetes ayiyonto?
Abaphandi baye bazama ukuqonda isizathu esithile sesifo se-Alzheimer. Ngoxa bekwazi ukuyihlolisisa ngokuchanekileyo nge-autopsy yengqondo ngenxa yokuba bayazi ukuba kubonakala njani kwaye ichaphazela njani izakhiwo zobuchopho, abazange bakwazi ukuqonda ukuba yintoni eyenza ukuba utshintsho lwengqondo kuphawulwe kwiAlzheimer.
Kodwa-ke, izazinzulu zenze iindlela ezininzi zokunciphisa umngcipheko wesifo se-Alzheimer, kuquka ukutya okunempilo , ukusebenza komzimba kunye nokuvuselelwa kwengqondo, phakathi kwamanye amaninzi.
Ngaba Uncedo LweSifo Sikashukela Unokunyanga Izifo Zama-Alzheimer?
Ukuba isifo se-Alzheimer sisinye uhlobo lwesifo sikashukela, ngaba amayeza enesifo sikashukela aya kunceda abantu abane-Alzheimer's ? Ucwaningo oluninzi luqalise ukukhangela oku kubonakala kwaye lubonakala lubonisa ukuba oku kunokwenzeka. Kuzo zombini izilwanyana kunye nezifundo zabantu, uphando luye lwabonisa ukuba le mishanguzo ye-insulin ikhuselekile kwiimeko ezingaqhelekanga eziphuhliswa kwisifo se-Alzheimer, ziye zaphucula ubuchopho bokukwazi ukuguqula i-glucose, kwaye zibonise ukuphuculwa kwengqondo ekusebenzeni kwengqondo kwezinye iimeko.
Imithombo:
Ukuphononongwa kweMithi yoNyango. Isiqendu 14, iNombolo 4, 2009. Ubudlelwane phakathi kweSifo se-Alzheimer kunye nesifo sikashukela: Uhlobo lwe-3 lwesifo sikashukela?
I-Alzheimer's Association. Izifo ze-Alzheimer kunye nohlobo lwe-2 lwesifo sikashukela: Yintoni isixhumanisi? Epreli 2011.
IiNqoloba zeNewurology. 2012; 69 (1): 29-38. I-Intranasal Therapy ye-Alzheimer's disease kunye ne-Amnestic Income Impairment.
INgqungquthela yamazwe ngamazwe kwi-Alzheimer's Drug Discovery. Ikhampani yoPhuhliso lweZingxaki zeMetabolic iveza iziphumo zecandelo lovavanyo lwezonyango . Septemba 9, 2013.
Umbhalo weSifo seSabethu kwiSayensi neThekhnoloji. 2008 ngoNovemba; 2 (6): 1101-1113. Ishicilelwe ngo-2008 ngoNovemba. Isifo se-Alzheimer's Type 3 Isifo seswekile-Ubufakazi bubuyiselwe.