Ngaba Iingxaki Zama-Alzheimer Ii-Germs Like the Cold Common?
Ngaba uyazibuza ukuba unako "ukufumana" isifo se-Alzheimer ukuchitha ixesha kunye nabantu abanalo? Qinisekisa ukuba, ukubamba isandla sikamakhulu okanye ukumnika ingxube akuyi kukunika isifo se-Alzheimer. Awuyi kuthatha umsebenzi njengomncedisi onesiqinisekiso esikhungweni kwikhaya lononophala kunye nokuchitha ixesha lokugqoka , ukuhlamba kunye nokunyamekela abantu kwi- unit of mental dementia unit .
Uphando malunga nendlela I-Alzheimer's Disease Isasazeka ngayo
Nangona isifo sika-Alzheimer sisasazeka ngokuqhagamshelana nabanye, uphando oluneentonga lubonakala lubonisa ukuba lunokuthi lube nolunye uhlobo lwesifo esithathelwanayo, mhlawumbi luhambelana nama-prions (iiproteni ezinokuthi izisele zeengqondo zisebenze). Kwizifo ze-prion , eziquka isifo se-Creutzfeldt-Jakob, iiprothini ze-prion ziqala ukungaqhelekanga kwaye zichaphazele ezinye iimpawu eziphilileyo ezitholakalayo emzimbeni, ezibangela ukuba izisele zife ebuchosheni nasekukhuleni komqondo. Nangona izibhengezo ezingekho phantsi kwempilo zisasazeka ngaphakathi komntu, akukho mngcipheko wesifo esichaphazela abanye abantu malunga naloo mntu, kubandakanya amalungu omndeni okanye abo banyamekela loo mntu.
Izifundo ngeePilisi
Iingcali zenzululwazi zenze uphando ngamagundane, zithatha amagundane aphilileyo kwaye ziyijobe ngeprotheni ye - beta amyloid ezivela kwiibhokhwe zamagundane ezazisungulwa ukuba zenze isifo se-Alzheimer kunye nokulahleka kwememori .
Abaphandi bafumanise ukuba iigundane ezafumene ijoyi ekugqibeleni zavelisa iprotheni efanayo ekwakheni zabo kunye nokulahlekelwa kweememori ukuba iilise ezine-Alzheimer zivele zikhona.
Abaphandi bazama ukulawula iiprotheyini ezisulelekileyo ngomlomo, amehlo, kunye neempumlo, kunye ne-intravenously, kwimichiza enempilo kwaye yafumanisa ukuba ezi ntlanzi azizange zibe nezibonakaliso zesifo se-Alzheimer.
Ucwaningo lwesibini olufanayo lufumanisa ukuba amagundane enempilo aphuhlise i-Alzheimer's xa ubuchopho babo bejojowe ngeengcambu zengqondo kwizigulane ze-Alzheimer's.
Ukufunda ngokutsha kunye nabantu
Olunye uphando oluthile lokufunda (isifundo esichaphazela abantu abachazwe kwinto ethile kubangenabo) siquka ukulandela abantu abangaphezu kwe-6100 abaye bajova ngaphambili ngamahomoni okukhula kwabantu. Abaphandi bavavanya loo mahomoni baza bafumanisa ukuba (ngokungazi ngelo xesha), babequlethe inani elincinci le- proteins ye- tau ne-beta amyloid ekhoyo kwiibinzana zabantu abane-Alzheimer's. Laba bantu baye bavavanywa ukuba baqaphele ukuba baye bahlakulela isifo se-Alzheimer. Ngaloo ndlela, akukho nxaxheba kwabafundi abaye bahlakulela isifo se-Alzheimer, nangona abaninzi bebancinci ngokusasazeka komzimba.
Ngaba Izixhobo Zensimbi Zenqwelomoya Zingasasaza Izifo Zama-Alzheimer?
Kwesinye sezifundo kunye namagundane achazwe ngentla, abaphandi bafaka iingcingo ezingenasici ezingenazintambo ngeeprotheni ezinesifo esipheleleyo se-Alzheimer kwaye zifake kwiibhokhwe zamagundane aphilileyo. Bafumanisa ukuba ezi ntlanzi zaza zenza i-Alzheimer's disease, kodwa kuphela ukuba iimbambo zaziphekiweyo ngaphambi kokumiselwa kwendawo esikhundleni sokuba yiplasma enyunyiweyo, indlela ephumelelayo yokubangela inzalo.
Abaphengululi baphando ngale ndlela kuba izifundo zangaphambili zibonise ukuba isifo seCreutzfeldt-Jakob, isifo sengqondo esivame ukubizwa ngokuthi "isifo seenkomo," sinokusasazeka kwesigulane ukuya kwesinye ngokusetyenziswa kwezixhobo zokugqitywa ezingazange zizaliswe ngokupheleleyo, kunye nezinye iindlela.
Ngaba Kukho Ingozi Yokukhulelwa Ngezifo Ze-Alzheimer's?
Isayensi isasebenza ekunqumeni oko kubangela ukuba izifo ezibangelwa yi-Alzheimer's disease. Siyazi ukuba izinto ezinobungozi ezifana nobudala, i-genetics, imbali yentsapho kunye nendlela yokuphila yonke inxalenye yomfanekiso. Kwakhona kunokwenzeka ukuba isakhiwo esithathelwanayo esinokuthi sinokubandakanyeka kwisifo se-Alzheimer, kodwa oku kungenakulungiswa kulo xesha kwaye kusekelwe kuphela kuphando lokuqala kunye namagundane.
Ukuba kubonakala ukuba iimbonondi zidlala indima kwisifo se-Alzheimer, kubalulekile ukukhumbula ukuba izifo ze-prion azifaki ngokungaqhelekanga okanye ukudibanisa kunye nabanye. Ngoko, qhubela phambili kwaye umququze loo mntu unesifo se-Alzheimer. Isifo sabo asithinteli nangayiphi na indlela, kwaye banokufumana ezinye zeenzuzo ezihambelana nokuchaphazeleka ngokomzimba kubantu abanomdemokhwelo , kuquka nokunciphisa uxinzelelo lwegazi, ukunciphisa intlungu kunye nokunciphisa ukuziphatha okucelomngeni kwimeko yesifo sengqondo .
ILizwi
Akuqhelekanga ukuba ukhathazeke ngesifo kwisifo, ingakumbi ukuba awukwazi kakuhle imeko okanye isizathu sokuba umntu akhuphe. Nangona kukho izinto ezininzi esingaziqondiyo ngokuphathelele kwesifo se-Alzheimer, siyazi ngokuqinisekileyo ukuba ukuchitha ixesha kunye nabantu abane-Alzheimer, ukubakhombisa okanye ukuzinakekela akuyi kubangela ukuba uhlakulele i-Alzheimer's.
Imithombo:
JAMA Neurology. 2013 kuMbhi; 70 (4): 462-8. Ukuphononongwa kwe-infectivity ye-Alzheimer kunye ne-Parkinson yezifo zamaprotheni kulabo abafumana i-hormone yokukhula komntu. http://www.ncbi.nlm.nih.gov/pubmed/23380910
I-Journal ye-Neuroscience.15 Meyi 2000, 20 (10): 3606-3611. Ububungqina bokulondoloza i-β-Amyloid nge-Intracerebral Infusion ye-Alzheimer Brain Extracts kwi-β-Amyloid Precursor Protein-Transgenic IiPice. > http://www.jneurosci.org/content/20/10/3606
I-Molecular Psychiatry 17 , 1347-1353 (Disemba 2012) | i-doi: 10.1038 / mp.2011.120. Ukuchithwa kwe-novo ye-amyloid-β yokuthunyelwa kwi-vivo. https://cen.acs.org/articles/90/i27/Alzheimers-Prion-Connection.html
Iinkqubo ze-National Academy of Science ze-United States of America. Agasti 4, 2009.106 (31). Ukuchithwa kwe-β-amyloidosis ye-cerebral: Intracerebral versus systemic Aβ inoculation. http://www.pnas.org/content/106/31/12926