Nangona i-statins ibe yinto ephambili yokunciphisa ubungozi benhliziyo kwiminyaka emibini edluleyo, kuye kwaba nokuphikisana okuqhubekayo malunga nendlela ama-statins anenzuzo ngayo kubasetyhini. Kule minyaka, idatha evela kwizilingo ezininzi zekliniki ziye zaxhasa, kodwa zingabonakali, ukuphumelela kweemimiselo kubasetyhini abane- coronary disease (CAD) . Ukuphikisana kwathatha isinyathelo esibalulekileyo kwisisombululo ngo-2015, nangona kunjalo, xa uvavanyo lweemeta lweemvavanyo ezininzi lweklinikhi lushicilelwe, kugqiba ukuba ama-statins kubasetyhini abonakala asebenzayo njengamadoda.
Kutheni iiferensi zibaluleke kangaka?
Izidakamizwa ze-statin zibhekwa zibaluleke kakhulu kwiyeza zonyango kuba ziphela ziilisi ze-cholesterol ezichanekileyo ezibonakaliswa ngokuqinisekileyo kwaye zinokuthenjisa umngcipheko wokuhlaselwa kwintliziyo, ukubetha nokufa kwizigulane ezinobungozi.
Enyanisweni, ngoku kubonakala kucacile ukuba ama-statins enza okungaphezulu nje kokunciphisa amazinga e-cholesterol yakho-anesiphumo sokuchasa; banceda ukukhusela i-blood clotting engavamile; Baya kunceda ukuzinzisa iiplanga ezithintekayo ezihlala zikhokelela ekuhlaselweni kwentliziyo kunye nemivimbo; kwaye zinezinye iziphumo ezincedisayo.
Izibonelelo ezikhethekileyo zemithi ye-statin ekukhuseleni iingxaki ze-cardiovascular, ezibhalwe kwiilingo ezininzi ezibalulekileyo zekliniki, zenza oogqirha banomdla kakhulu ngokusetyenziswa kwezi gulana kwizigulane zabo ezineengxaki zempilo yengqondo.
Kutheni Kukho Ukuphikisana Ngeentetho Zabasetyhini?
Ukuphikisana kuye kwabakho ngenxa yokuba ubungqina bokuba ama-statins asebenzayo ekuphuculeni iziphumo zempilo ye-cardiovascular has been definitive less in women than men.
Kwiminyaka, izilingo ezinkulu ezinokwenziwa kweekliniki ezibhalisa amadoda kunye nabasetyhini ngeentlobo zangaphambili ze- myocardial (ukuhlaselwa kwintliziyo) okanye i -coronary syndrome eyiyo, oko kukuthi, kubantu abaye banesifo esibalulekileyo se-coronary disease (CAD) , baye babonisa i-statins ukuba isebenze ekunciphiseni iziganeko zenhliziyo, kuquka ukuhlaselwa kwentliziyo nokufa.
Kubantu abangenayo i-CAD, kodwa ukuba ingozi ye-CAD iphakamileyo, izilingo ezingenamsebenzi ziye zabonisa iziphumo eziphuculweyo zomoya kunye neemimiselo, nangona kunjalo.
Kodwa xa uhlalutya iziphumo ezifunyenwe kuphela phakathi kwabasetyhini ababhalisile kulezi zilingo zonyango, iinzuzo zeemimiselo ziye zahluleka ukufikelela ekubalulekeni kwamanani. Oko kukuthi, iinzuzo zeemimiselo zabasetyhini zazingavumelekanga.
Yiyiphi Incazelo Yolu Bungqina Bokungqina?
Yilapho ukuphikisana kuye kwaba khona. Kukho iinkcazelo ezimbini ezinokwenzeka. Okokuqala, kukuba, mhlawumbi ama-statins asebenzi kakuhle nakwabasetyhini njengamadoda. Uninzi lweengcali ziqinisekile ukuba oku kunjalo. Ingcaciso yesibini kukuba nje abafazi abaneleyo babhalisiwe kwiimvavanyo zonyango ezikhoyo ukwenzela ukuba balinganise ukusebenza kweemimiselo. Enyanisweni, ininzi yezi zilingo, ubukhulu beenzuzo ezibonwe kunye neemimiselo zibonakala zifana kunye nabasetyhini njengamadoda, kodwa abafazi abaneleyo babhalisiwe ukuba bafikelele ekubalulekeni kwamanqaku kwinqanaba lenzuzo.
Ziziphi ubungqina obutsha?
Ekuqaleni kuka-2015, uhlalutyo olukhulu lweemeta lupapashwe kwi- Lancet ingxelo yokuba, xa izinga le-cardiovascular risk lithathwa ingqalelo, imimiselo ibonakala iyasebenza nakwizibhinqa kunamadoda.
Olu pho nonongo luqhutywe yi-Cholesterol Treatment Trialists '(CTT) Ukusebenzisana, ukuhlalutya izilingo ezingama-27 ezinokwenziwa kweempawu zonyango kunye neemimiselo zaso, ezibhalise ngokubanzi ababengama-46,000. Uhlalutyo ngale nani elikhulu labasetyhini lagqiba ukuba ama-statins asebenzayo kubasetyhini njengamadoda ekunciphiseni umngcipheko olandelayo weziganeko ezinkulu ze-cardiovascular. (Ezi ntshukumo eziphambili ze-cardiovascular include incidents of heart attack, strokes , imfuno ye- stents okanye i- surpass operation , kunye nokufa komzimba.) Impembelelo yemimiselo yayilingana kumadoda nakwabesifazana kuwo onke amanqanaba omngcipheko we-cardiovascular risk.
Ngaba Iimpawu ZeeNkcazo Kufanele zisetyenziswe kwabasetyhini?
Ngoku sinokuthi ubungqina obuninzi obukhoyo bubonisa ukuba i-statins inokubaluleka kubafazi njengoko iphakathi kwamadoda, kwaye ngokuqhubekayo, ukuba isifo sesigulane akufanele sibe yinto ebalulekileyo ekunqumeni ukuba okanye ungasebenzisi i-statins.
Ukuthatha isigqibo malunga nokunyangwa komzimba kufuneka kusekelwe kwinqanaba leengxaki zakho ze-cardiovascular risk, kunye nokuqwalaselwa ngenyameko ngawe kunye nogqirha wakho malunga neenzuzo ezinokuthi zenziwe ngama-statins ngokumalunga nemingcipheko. Nangona ezi zihlandlo zihlala zifuna ukuba ngabanye, ubungqina obungcono obukhoyo bubonisa ukuba ubulili akudingeki ukuba badlale indima ethile kwinkqubo yokwenza izigqibo.
> Imithombo:
> I-Cholesterol Treatment Trialists '(CTT) Ukusebenzisana. Ukusebenza kunye noKhuseleko lwe-LDL-Ukwehla kweNyango phakathi kwamadoda nabafazi: ukuhlaziywa kweMeta-ngamnye kweeNkcukacha ezivela kwi-174,000 abachaphazelekayo kwii-27 eziLinganisiweyo. Lancet 2015; INGXELO: 10.1016 / S0140-6736 (14) 61368-4.
> Davignon, J. Uncedo lwe-Cardiovascular Effle Pleiotropic Impact of Statins. Uhambo luka-2004; 109: III39.
> Nissen, SE. I-dose ephakamileyo kwiStellish Syndrome. Akunjalo nje ngamazinga aPilid. JAMA 2004; 292: 1365.