Isizathu esona sizathu sokuba ugqirha ufuna ukunciphisa i-cholesterol yakho kukunciphisa umngcipheko weentlungu zentliziyo kunye nokufa kwangaphambi kokufa kwe- coronary disease (CAD).
Kwaye nangona kukho iindidi ezininzi zamachiza ziye zavunywa ukuba zinciphise i- cholesterol ye-LDL (i-LDL "ifomu" embi ye-cholesterol), kuphela iziyobisi eziboniswe ngokuphindaphindiweyo ukunciphisa umngcipheko wokuhlaselwa kwentliziyo kunye nokufa kwangaphambi kwexesha kubantu abanesifo senhliziyo umngcipheko ophakanyisiwe yilo miselo .
Enyanisweni, uphando olukhulu luye lwaphakamisa ukuba ezinye zeyeza ezingekho komzimba ze-cholesterol imishanguzo zingadala iziphumo.
Okwangoku, kucatshangelwa ukuba i-statins ingcono kunezinye iziyobisi kwiziphumo eziphuculweyo kuba zinemiphumo emininzi kwintsikelelo kwi-cholesterol. Ezi ziphumo "ezingaphezulu" zinokukunceda ukukhusela i- atherosclerotic plaques kwimibhobho ye-coronary kwaye inokukunceda ukukhusela i -coronary syndrome .
Iimiphumo ezingezantsi ze-Cholesterol-I-Lowering Effects yeeNkcazo
Imiphumo "engaphezulu" engeyiyo ye-cholesterol-yehlisa i-statins ibandakanya:
- Impembelelo echasayo.
- Impembelelo yokulwa ne-clotting.
- Umphumo ocacileyo we-plaque-stabilizing effect.
- Ukunciphisa ama -pro-protein level (CRP)
- Ukuphuculwa komsebenzi we-vascular.
- Ukunciphisa i-arrhythmias yingozi yengqondo.
- Olunye uhlobo lokunciphisa (ukuhla) kweeplates ze-atherosclerotic ngokwabo.
Ezi ziphumo "ezingaphezulu" zeemimiselo zingabaluleka (okanye zibaluleke nakakhulu) kunokunciphisa i-cholesterol ekuphuculeni iziphumo.
Ngokomzekelo, iziphumo ezingezona i-cholesterol zizathu sokuba ukunika i-statins ngexesha lokuhlaselwa kwentliziyo ngokukhawuleza kunika inzuzo yekliniki ngokukhawuleza - oku akusona isizathu ongayilindela ukuba kuphela into eyenziwa yi-statins ekunciphiseni i-cholesterol. Ezi ziphumo ezingezantsi ze-cholesterol zingachaza kwakhona ukuba kutheni ama-statins angaphucula iziphumo kwizigulane ezithile ezibeka ingozi kwiinqwelisi ze-cholesterol ezingakhange ziphakanyiswe ngokukhethekileyo.
Enyanisweni, iinzuzo ezizodwa zemimiselo ziye zabangela ezinye iingcali ukuba zibuze yonke "i- cholesterol hypothesis " (ingcinga yokuba ukunciphisa i-cholesterol iya kunciphisa umngcipheko). Ezi "zizonyango" zikholelwa ukuba akusilo ukunciphisa i-cholesterol ye-LDL eyenza ama-statins aphumelele ekuphuculeni iziphumo, kodwa ezinye iziphumo zeziyobisi ze-statin. Ngoko (bayaqhubeka ukubonisa) mhlawumbi ukunciphisa i-cholesterol ngokwayo akubalulekanga njengoko sonke sicinga.
Ngaphantsi
Enoba yintoni na, xa ugqirha wakho uncoma unyango lwe-statin njengonyango olungcono kunyango lwe-LDL ye-cholesterol ephakamileyo, ubonisa nje ulwazi lwakhe ngobungqina obuninzi obubonisa ukuba i-statins inenzuzo ngokukhethekileyo.
Unokufunda ngezinye iindlela zokwehlisa i-cholesterol . Kwaye nantsi inqaku malunga nendlela yokugqiba ukuba ngaba ufuna ukuphathwa nge-cholesterol.
> Imithombo:
> Liu PY, Liu YW, Lin LJ, et al. Ubungqina beStatin Pleiotropy Kwabantu: Imiphumo eyahlukeneyo yeeNkethi kunye ne-Ezetimibe Kwi-Rho-Associated-Coil-Coil-Coiled-Coil equkethe iProtein Kinase Activity, Umsebenzi wokuQiniseka, kunye nokuvutha. Ukuhamba ngo-2009; 119: 131.
> Nissen, SE. Izitatimende eziPhakamileyo kwiiConomic Syndrome. Akunjalo nje ngamazinga aPilid. JAMA 2004; 292: 1365.
> Stone NJ, uRobinson JG, uLichtenstein AH, et al. I-ACC / I-AHA Isikhokelo kwi-Treatment of Blood Cholesterol Ukunciphisa Umngcipheko we-Cardiovascular Risk Kwabantu abadala: Ingxelo ye-American College of Cardiology / i-American Heart Association Umsebenzi weKomiti yeziKhokelo. Ukuhamba ngo-2014; 129: S1.