I-Livalo (i-pitavastatin) iyeza ye-cholesterol-iyanciphisa imithi eyimigangatho ye - statin yamachiza. Isetyenziselwa ukuphakanyiswa kwamanqanaba e-lipid kwi-hyperlipidemia ephambili okanye i-dyslipidemia exubekileyo kwiimeko apho ukutya, ukutshintsha kwindlela yokuphila, okanye ezinye iimichiza akupheli ngokupheleleyo amanqanaba eepidid. I-Livalo ngenye yeempawu ezinamandla kakhulu kwiimarike.
Ngokwezifundo, abavelisi be-Livalo, 2 mg weLibalo inokusebenza ngokunciphisa i- lipids njenge-10 mg ye- Lipitor (i-atorvastatin).
Ukongezelela, i-2 mg yeLibalo iyanciphisa i-cholesterol ukuya kufana ne-20 mg yeZocor (simvastatin). Njengeminye imimiselo, i-Livalo ithinta zonke iinkalo zeprofayili yakho ye-cholesterol: Ihlisa i- LDL kunye ne-triglycerides kwaye iphakamisa i- HDL . Izifundo eziphambili ezihlolisayo umphumo weLibalo kumanqanaba eepid zibonise ukuba:
- I-cholesterol yeLDL iyancishiswa ngo-44%
- Iqondo le-cholesterol lilonke liyancipha malunga ne-32%.
- I-Triglycerides iyancipha ngo-19%.
- Iinqwelo ze-cholesterol ze-HDL zonyuka ngama-5%.
- I-Apolipoprotein B iyancipha malunga ne-35%.
I-Livalo yavunyelwa ukuba isebenziswe e-United States yi-Food and Drug Administration (i-FDA) ngo-Agasti ka-2009. Ngaphambi kokuvunyelwa e-US, i-pitavastatin yayisetyenziselwa ukusebenzisa kwamanye amazwe ngaphezu kweminyaka emihlanu ngaphambili.
I-Livalo Isebenza Njani?
I-Livalo ibimbela i-enzyme ebizwa ngokuthi i-3-hydroxy-3methylglutaryl coenzyme A (i-HMG CoA) yokunciphisa, eyona iprotheyini ebalulekileyo efunekayo kwimveliso ye-cholesterol emzimbeni.
Eli nyathelo linciphisa i-cholesterol epheleleyo, i-LDL, ne-VLDL i-cholesterol emzimbeni.
I-Livalo ifanele ithathwe njani?
I-Livalo ifumaneka kwifom yefowuni kwaye ingathathwa kunye okanye ngaphandle kokutya kanye ngosuku, njengoko kulandelwa ngumboneleli wakho wezempilo. Imilinganiselo ye-Livalo akufanele ifike kwi-4 mg ngosuku. I-Livalo kufuneka ithathwe ngokubambisana nokutya ukuze unciphise i-cholesterol yakho kunye ne-triglycerides.
I-Livalo idla ngokumiselwa xa utshintsho lwendlela yokuphila okanye enye imithi ayinciphisi kakuhle i-lipids yakho.
Kufuneka uqinisekise ukuba uye kwiindawo zokuqeshwa kwabamncedisi bempilo rhoqo ngenxa yokuba uya kufuneka ukuba aqaphele amanqanaba akho e-lipid, kunye nezinye iiparitha, ngelixa uthabatha le nyilisi.
Ngubani Akufanele Athathe I-Livalo?
Ukuba unenye yeemeko zonyango ezidweliswe ngezantsi, akufanele uthathe iLibalo. KWEEMIHLANGO, umboneleli wakho wezempilo unokukubeka unyango oluthile ukuze unciphise i-lipids yakho:
- I-allergy to Livalo . Ukuba uye wangaphambili u-Livalo okanye nayiphi na izithako zayo, akufanele uthabathe eli gciwane.
- Isifo sesibindi esisebenzayo . Ukuba unesifo sesibindi esishukumisayo okanye amanqanaba enzyme angabonakaliyo, i-Livalo akufanele ithathwe.
- Ukukhulelwa. I-Livalo ihlelwe njengeNqanaba lokukhulelwa kwe-X. I-Livalo iboniswe ukuba iwele umnqamlezo we-placental kwizintumbane kwaye kukho iingxelo zokulahleka kwezinto kunye nokungahambi kakuhle kwezilwanyana kwizifundo zezilwanyana. Ukongezelela koko, oku kwachazwa nakwabesetyhini abakhulelweyo abasebenzisa amayeza omzimba. Ukuba uceba ukukhulelwa okanye sele sele ukhulelwe kwaye uthatha uLibalo, umboneleli wakho wezempilo uya kuluqonda ubuncedo bokuthatha unyango kwimpilo yakho kunye nemingcipheko yomntwana wakho.
- Unesi. I-Livalo iboniswe ukuba iwele kwibele. Ayaziwa ukuba luhlobo luni lwefuthe eli nokuba nalo kumntwana wakho.
- I- Cyclosporine. Eli mayeza anokwandisa amazinga e-Livalo emzimbeni, enokubangela iziphumo ezinobungozi emzimbeni. Umvelisi uncoma ukuba ukuba uthatha iLibalo, akufanele uthathe i-cyclosporine.
Ziziphi iimfuneko ezifunekayo ukuba zikhangelwe ngelixa zithatha incwadi?
Ukuba uthabatha uLibalo, umboneleli wakho wezempilo unokufuna ukubeka iliso ngakumbi xa unemibandela ethile yezokwelapha ezinokugqithiswa ngokuthatha iyeza. Ukuba unemiqathango elandelayo ingezantsi, umboneleli wakho wezempilo unokugqiba ekubeni aqale kwiLibalo kwi dose ephantsi, kwaye uya kufuna ukubeka iliso kuwe ukuqinisekisa ukuba okanye ukuthatha iLibalo kungakulimaza.
Ezi meko zonyango zibandakanya:
- Amanzyzy ezinobindi. Kwizifundo, iLibalo yanda i-enzyme ye-foartate yaminotransferase (AST) kunye ne-alanine aminotransferase (ALT). Nangona amaninzi ukwanda okwenyuka kwexeshana, umboneleli wakho wezempilo uya kubeka esweni la manqanaba ukuqinisekisa ukuba i-enzyme yakho yesibindi ayiphakanywanga kumanqanaba angozi.
- Izifo zesifo. Ukuba unesifo sengqondo esifutshane okanye esinamandla, umboneleli wakho wezempilo unokukuqala kwi-dose ye-Livalo ephantsi kakhulu kwaye ujonge impilo yakho ngelixa unyango.
- Amanqanaba e-blood glucose ephakamileyo. Ucwaningo luye lwabonisa ukuba iLifalo inokwandisa i-hemoglobin A1C kunye nokuzila ukutya kwe-glucose. Ukuba unesifo sikashukela, umboneleli wakho wezempilo unako ukubeka iliso kula maqumrhu egazini lakho kwaye ulungise idosi yakho yeLibalo.
Ziziphi iindidi zeempembelelo zecala Ngaba iLifalo iCause?
Iziphumo eziqhelekileyo ezichaphazelekayo zibandakanya iintlungu zentlungu, iingxaki zesisu (ezifana nokuqhawuka okanye isifo sohudo), intlungu yesisu, kunye nentlungu kwimida. Ezinye iziphumo eziqhelekileyo eziqhelekileyo ezichaphazelekayo ziquka intloko yesifo kunye nentlungu edibeneyo. Ukuba unayo nayiphi na imiphumo emibi ekuthathweni kweLibalo ehlala ixesha elide okanye ephazamisayo, kufuneka uvumele umboneleli wakho wezempilo ukuba azi.
Njengamanye ama-statins, umphumo ongenabunqabileyo - i-rhabdomyolysis - ingenzeka nakwabantu abathile bathatha uLialo. Iimpawu ze-rhabdomyolysis ziquka ukuxhalaba kunye nokubuthathaka, kunye nomchamo ombala we-soda. Umngcipheko wakho wokufumana ezi ziphumo zecala unokuthi uyenze ukuba uthatha amanye amayeza, ukwanda kweminyaka, kunye nezinye iimeko zonyango. Ukuba unayo nayiphi na impawu ye-rhabdomyolysis, kufuneka ukhawuleze uxelele umboneleli wakho wezempilo.
Ngaba zikhona naziphi na iimishanguzo ezinokusebenzisana neLibalo?
La machiza alandelayo angasebenzisana neLibalo, okwandisa amathuba okuba nemiphumo emibi (ingakumbi i-myopathy). Ngaphandle kwezidakamizwa ezincitshisiweyo ezisezantsi apha, ezi zidakamizwa zinokwandisa amazinga eLibalo emzimbeni wakho.
- Izidakamizwa ezinciphisa i-cholesterol (i- nicotinic acid , i-fibrates)
- Rifampin
- Erythromycin
- Colchicine
Lona alukho uluhlu olupheleleyo. Kufanele uvumele umboneleli wakho wezempilo ukuba azi onke amayeza - kuquka imichiza yemithi kunye nezidakamizwa ezingaphezu kwee-counter-ezithathayo ngexesha uthabatha uLialo. Oku kuya kukunceda umboneleli wezempilo ukuba akubekele iliso malunga nokusebenzisana kwezidakamizwa xa uthabatha amayeza. Ukuba unyanzelekile ukuba uthathe esinye sezidakamizwa ezibhaliweyo ngasentla, umboneleli wakho wezempilo unokufuna ukulungelelanisa umthamo wakho, ukubeka iliso ngokusondeleyo kwimiphumo emibi, okanye ukuyeka enye yamachiza.
Ngaphantsi
I-Livalo yiyona nto yakutshanje i-lipid-ityhila imithi evunyelwe kuthi e-United States. Kweminye uphando, kubonakala kusebenza ngendlela efanelekileyo ekunciphiseni iip lipids ngamanqanaba afanelekileyo we-simvastatin kunye ne-atorvastatin. I-Livalo ibonakala ihamba ngomnye umzila kwisibindi ukuze ilandelelwe ngokuthelekiswa nezinye iimimiselo, ezinciphisa inani lezenzo zamathambo ezichazwe ngabantu abathatha le myeza. Nangona kunjalo, iLifalo ayizange ifundwe ngokubanzi ekuthintekeni kokufa okanye ukukhubazeka ngenxa yesifo senhliziyo.
Imithombo
Duggan ST. I-Pitavastatin: ukuhlaziywa kokusetyenziswa kwayo ekulawuleni i-hypercholesterolemia okanye i-dyslipidemia edibeneyo. Iziyobisi 2012; 72: 565-584.
Ose L, uBudinski D, Hounslow N, et al. Ukuthelekiswa kwepitavastatin kunye ne-simvastatin kwi-hypercholesterolaemia yokuqala okanye i-dyslipidaemia ehlangeneyo. I-Curr Med Res & Opin ka-2009; 25: 2755-64 15.
UBudinski D, uArnneson V, uHounslow N, et al. I-Pitavastatin ithelekiswa ne-atorvastatin kwi-hypercholesterolemia yokuqala okanye i-dyslipidemia ehlangeneyo. Iklinikhi yase Lipidol 2009; 4: 291-302
I-LIVALO [ifakwe yephakheji]. Cincinnati, OH: Kowa Pharmaceuticals eMelika, ngo-10/2013
Micromedex 2.0. I-Truven Health Analytics, Inc. iGreenwood Village, CO. Iyatholakala kwi: http://www.micromedexsolutions.com. Ufikelele ngoFebruwari 10, 2016