I-Zocor (i-simvastatin) yipilisi ye-cholesterol-eyanciphisa i- classin class of drugs. Isetyenziselwa ukuphatha amanqanaba aphezulu e-cholesterol, i-LDL i-cholesterol, i-triglyceride kunye nama-apolipoprothein B amanqanaba kubantu abafumene i-hyperlipidemia yokuqala okanye i-dyslipidemia exubekileyo kwiimeko apho ukutya, ukutshintsha kwindlela yokuphila, okanye ezinye iimichiza ezingezantsi ngokupheleleyo.
Ukongezelela, i-Zocor isetyenziselwa ukunciphisa umngcipheko wokuba nesifo senhliziyo kunye nokushaywa yintlungu kubantu abanezifo okanye ezinesifo senhliziyo.
Izifundo eziphambili ezihlola umphumo we-Zocor 20 ukuya ku-40 mg zibonwe ezi ziphumo zilandelayo kunye neZocor:
- Inganciphisa i-LDL ye- cholesterol ngokulinganiselwa kuma-35%.
- Inokunciphisa amazinga e-cholesterol amaninzi ngama-25%.
- Inokunciphisa i-triglycerides ngomyinge we-10%.
- Inokunyusa amazinga e-HDL ye-cholesterol ngo-8%.
I-Zocor iye yaboniswa kwizifundo zokunciphisa ukufa ngenxa yesifo senhliziyo ngokufikelela kuma-42%
I-Zocor yavunywa ukuba isebenziswe yi-Drug Administration (FDA) ngoDisemba ka-1991.
Zocor Work?
I-Zocor ibophelela kwaye ivimbele i-enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) iyanciphisa, i-enzyme enkulu kwinkqubo ye-cholesterol eyayihamba ngayo, le nyathelo yanciphisa inani le-cholesterol eyenziwa esibindi.
I-Zocor ifanele ithathwe njani?
I-Zocor ithathwa ngomlomo, kunye okanye ngaphandle kokutya kanye ngosuku, njengoko ilawulwa ngumboneleli wakho wezempilo.
Nangona izilingo eziqhelekileyo ezisetyenziselwa ukuphatha i-lipids zakho ziqala ukusuka kwi-5 ukuya kwi-40 mg, umniki-nkonzo wakho wezempilo unokukuqala kwiqondo eliphantsi kwaye ukwandise umthamo wakho ngokukhawuleza, ngokusekelwe kumanqanaba akho e-LDL kunye nempendulo yakho kumachiza. I-Zocor 80 mg ingabangela intlungu ye-muscle yokwanda - kuquka ne-rhabdomyolysis - ngoko le dose ayisetyenziswanga ngaphandle kokuba uyibekezele ixesha elide ngaphandle kwemiphumo emibi.
Ukutya okunciphisa umzimba kufuneka kulandelwe ngenkathi uthatha iZocor.
Ngubani Akufanele athathe iZocor?
Ukuba unenye yeemeko zonyango ezidweliswe ngezantsi, akufanele uthathe iZocor. Kule meko, umboneleli wakho wezempilo unokukubeka kwinkqubo eyahlukeneyo yokunciphisa i-lipids yakho:
- Utywala. Ukuba uye wangaphambili u-Zocor okanye nayiphi na izithako zayo, akufanele uthabathe eli nyanga.
- Isifo sesibindi esisebenzayo. Ukuba unesifo sesibindi okanye ungachazwanga, amazinga enzyme enesibindi aphakanyisiwe, iZocor akufanele ithathwe.
- Amanye amayeza. Ukuba uthatha i-cyclosporine, i-gemfibrozil, i-danazol, okanye enye imithi enqanda kakhulu indlela yokuhamba, i-CYP3A4, akufanele uthathe iZocor.
- Ukukhulelwa. I-Zocor ikwahlulwe njengeCandelo loKhulelwa kweX-X. I-Zocor iboniswe ukuba iwele umnqamlezo we-placental kwiinqongi kwaye kuye kwavela iingxelo zokulahleka kwezinto kunye nokungahambi kakuhle kwezilwanyana kwizifundo zezilwanyana. Ukongezelela koko, oku kwachazwa nakwabesetyhini abakhulelweyo abasebenzisa amayeza omzimba. Ukuba uceba ukukhulelwa okanye sele sele ukhulelwe kwaye uthatha uZocor, umniki-nkonzo wakho wezempilo uzakujonga ubuncwane bokuthabatha imithi kwimpilo yakho kunye nemingcipheko enokwenzeka kumntwana wakho.
- Unesi . I-Zocor iboniswe ukuba iwele ebisi yobisi. Ayaziwa ukuba luhlobo luni lwefuthe eli nokuba nalo kumntwana wakho.
Iimeko ezifuna ukuba zijongwe
Ukuba uthatha iZocor, umboneleli wakho wezempilo unokufuna ukubeka iliso ngakumbi xa unemibandela ethile yezokwelapha. Ukuba unemiqathango elandelayo ngezantsi, umboneleli wakho wezempilo unokugqiba ekubeni aqale kwiZocor kwi dosi ephantsi kwaye uya kufuneka akubekele iliso ukuze aqinisekise ukuba okanye ukungathathi iZocor kuya kuba yingozi kuwe. Ezi meko zonyango zibandakanya:
- Amanzyzy ezinobindi. Kwizifundo, iZocor yandise i-enzyme yesibindi i-aspartate aminotransferase (AST) kunye ne-alanine aminotransferase (ALT) kwizifundo. Nangona amaninzi ukwanda okwenyuka kwexeshana, umboneleli wakho wezempilo uya kubeka esweni la manqanaba ukuqinisekisa ukuba i-enzyme yakho yesibindi ayiphakanywanga kumanqanaba angozi.
- Amanqanaba e-blood glucose ephakamileyo. Izifundo zibonise ukuba i-Zocor inokwandisa i- hemoglobin A1C kunye nokuzila ukutya kwe-glucose. Ukuba unesifo sikashukela, umboneleli wakho wezempilo unako ukubeka iliso kula macandelo egazini lakho kwaye ulungele umthamo wakho weZocor.
- Izifo Zengqondo. Umboneleli wakho wezempilo uyakukuqala kwisebe eliphantsi kwaye akulonge ngokukhawuleza.
Imiphumela
Iziphumo eziqhelekileyo ezichaphazelekayo zibandakanya intloko yesifo, intlungu yesisu, isicathulo, isambiso, kunye nezifo eziphezulu zokuphefumula. Ukuba unayo nayiphi na imiphumo emibi ekuthathweni kweZocor ehlala ixesha elide okanye ephazamisayo, kufuneka uvumele umboneleli wakho wezempilo ukuba azi.
Njengamanye ama-statins, impembelelo engavumelekanga yonyango - i-rhabdomyolysis - ingenzeka nakwabantu abathatha iZocor. Iimpawu ze-rhabdomyolysis ziquka ukuxhalaba kunye nokubuthathaka, kunye nomchamo ombala we-soda. Umngcipheko wakho wokufumana ezi ziphumo zecaleni kunokuthi uyenze xa uthatha amanye amayeza, ukwanda kweminyaka, uthatha umthamo we-80 mg weZocor kunye nezinye izimo zonyango. Ukuba unayo nayiphi na impawu ye-rhabdomyolysis, kufuneka ukhawuleze uxelele umboneleli wakho wezempilo.
Iimpawu ezingasinxulumana neZocor
Ngaphandle kwe-cyclosporine, i-gemfibrozil, kunye neminye imishanguzo ekhankanywe ngasentla, izidakamizwa zilandelayo zinokusebenzisana noZocor - ukwandisa amathuba okuba nemiphumo emibi. Amachiza alandelayo anokunyusa amazinga eZocor okanye amanye amayeza emzimbeni wakho:
- Izidakamizwa ezinciphisa i-cholesterol (i- nicotinic acid , i-fibrates)
- Ezinye iimithi zentliziyo - njenge-verapamil, diltiazem, amiodarone, i-amlodipine
- Protease inhibitors
- Colchicine
- Coumadin (warfarin)
Ekubeni oku akulona uluhlu olupheleleyo, kufuneka uvumele umboneleli wakho wezempilo ukuba azi zonke iyeza-kuquka imichiza yemithi kunye neziyobisi ezingaphezulu kwezinto-ozithathayo xa uthatha iZocor. Ukuba unyanzelekile ukuba uthathe esinye sezidakamizwa ezibhaliweyo ngasentla, umboneleli wakho wezempilo unokufuna ukulungelelanisa umthamo wakho, ukubeka iliso ngokusondeleyo kwimiphumo emibi, okanye ukuyeka enye yamachiza.
Ngaphantsi
I-Zocor yimiba echazwe ngokuqhelekileyo yile nto isetyenziselwa ukuphucula iphrofayili yakho yeepidid kwaye unciphise ingozi yokufa ngenxa yokuhlaselwa yintliziyo okanye ukubetha. I-Zocor iphinda ifumaneke kwifom yesiza, ikuvumela ukuba ufumane le mayeza ngexabiso elibiza ngokuthelekiswa namayeza egama legama. Nangona iphumelele, kukho imiphumo emibi kunye nokusebenzisana kwezidakamizwa omele ulinde xa uthatha iZocor. Ngoko ke, kufuneka uqiniseke ukuba uhlala uqeshwe kunye nomboneleli wakho wezempilo ukuze akwazi ukujonga inkqubela yakho kwiyeza.
Imithombo:
I-Zovor (iSimvastatin) [ifakwe yephakheji]. Merck: Isikhululo se-Whitehouse, NJ. Ukuhlaziywa 3.2015.
Micromedex 2.0. I-Truven Health Analytics, Inc. iGreenwood Village, CO. Itholakala kwi-http: //www.micromedexsolutions.com.
Iincwadi ze-4S Study Authors. Uvavanyo olungalindelekanga lweCholesterol Ukuphungula ngo-4444 izigulane ezinezifo zentliziyo yeCoronary: IsiCwangciso soPhulo lweScandinavian Simvastatin. Lancet 1994 uNgo-19; 344 (8934): 1383-9.