IiNkcazo zinikela ngeNcedo elincinci kwizeMpilo
Iimpawu zezona zinto zichanekileyo zichanekileyo ze- cholesterol-downing medication ezichaphazela zonke iinkalo zeprofayili ye-cholesterol.
Iinzuzo zeemimiselo ziquka:
- Ukunciphisa iLDL kunye namanqanaba e-triglyceride
- Ukukhulisa amazinga e-HDL
- Ukunciphisa ingozi yesifo senhliziyo
- Ukuthintela ukuhlaselwa kweentliziyo kunye nokubetha kwezigulane esele isifo sesifo
Nangona phakathi kwezibonelelo ezithatha izitembu ezinokuthi zibe nazo, ezinye izigulane ziyabacima ngenxa yokuba zicinga ukuba iziphumo zempembelelo zingabangela ingozi ngaphezu kokulungileyo.
Ngaba izigulane zichanekile ukuphepha i-statins ngenxa yemiphumo emibi?
Uncedo oluncinci kakhulu kwizigulane eziphilileyo
Iitatimins zinokunceda izigulane ezineembali zesifo senhliziyo, kodwa umgangatho wokumisela izitishi kubantu abanempilo yokunciphisa umngcipheko unokuphela ekupheleni komhleli we-2015 opapashwe kwiphepha lezonyango lwe-Prescriber. Ingxelo ithi emva kokuthatha ama-statins iminyaka emi-5, kuphela i-0.5 ekhulwini labantu abaphilileyo abaphephe ukuhlaselwa intliziyo okanye ukubetha. Ababhali, i-cardiologist yaseLondon kunye noprofesa wonyango wase-US, bafuna ukubhalwa ngokutsha kwezikhokelo zaseMelika naseBrithani.
Ukunyuka kwe-Enzyme Elevation kuyimpembelelo yecala leeNkcazo
Zonke izidakamizwa ze-statin ziphakamisa i-enzyme yesibindi kwinqanaba elithile, kubandakanywa i-aminotransferase (AST) kunye ne-alanine aminotransferase (ALT), apho umboneleli wakho onakekelo lwempilo phambi kokuba uqale unyango lwe-statin, emva kweenyanga ezintathu emva kokuqala kweemimiselo, kunye ncinane ubuncinane kwiinyanga ezintandathu ngelixa unyango lwe-statin.
Abo abanama-enzyme ezinobindi abanokuthi bangaboni naziphi iimpawu.
Amanqanaba asemgangathweni ama-statins aphakamisa i-enzyme yesibindi kwi-1 pesenti yezigulane, ngokuqhelekileyo kwiinyanga ezine zokuqala. Ubungakanani balo bonyuka banda kubantu abadala kunye nalawo athatha amanye amachiza anokusebenzisana nama-statins okanye aphakamise i-enzyme yesibindi.
Esi siphumo sesigxina se-statin sixhomekeke kwintsholongwane, oko kuthetha ukuba i-dose yama-statins ophakamileyo uyaphakamisa, mhlawumbi uya kuba nokunyuka kwama-enzyme yesibindi.
Kukho iingxelo ezinqabileyo zokuhluleka kwesibindi kunye nesifo sofuba esibandakanya ama-statins kunye nama-enzymes ezinobindi. Izifundo zangoku azikhange zikwazi ukuseka isiqhagamshelo esicacileyo phakathi kwesimo se-statin nesifo sesibindi.
Amanqanaba enzyme ephakamileyo ephakamileyo abuyele kwindawo evamile xa uyeka ukuthatha ama-statins.
Ubuhlungu beMisipha kunye nobuthathaka Ngaba yimpembelelo yamacandelo
Iimpawu ze-Myopathies, okanye iimpawu ezinjengobuthathaka kunye nentlungu, yinto enye yempembelelo yamacandelo.
I-Myopathies ivela kwi-myalgias epholileyo, okanye iintlungu zomzimba , kwimeko esongela ubomi ebizwa ngokuba yi-rhabdomyolysis. I-myopathy exhaphakileyo ehambelana nokusetyenziswa kwe-statin, i- myalgia , ivele kuphela kwi-1 kwi-1 000 yezigulane ezithatha iziqu.
Ithuba lokufumana le mpembelelo yecala le-statin landa xa usakhula, kunye neendleko eziphezulu kunye ngelixa uthabatha amanye amayeza. Ezi zibonakaliso ziya kubonakala zingangeenyanga ezine zokuqalisa unyango lwe-statin.
I-Rhabdomyolysis, enye i-myopathy eyenzeka ngokusetyenziswa kwe-statin, inqabile kakhulu kwaye iyingozi xa ingaphathwa kakuhle. Iyenzeka kumntu oyedwa kwabangama-10 000 abathabatha amashishini.
Iimpawu zeRhabdomyolysis ziquka:
- Intlungu ebuhlungu
- Ubuthathaka
- Ukwandisa ngokukhawuleza inani lee-creatinine phosphokinase
Ngaba Iingenelo Ziyongamela Imingcipheko?
Esi sinqumo wena kunye nomboneleli wakho wezempilo kufuneka enze.
Ukuba uthatha iimimiselo kwiimeko zempilo zangoku, mhlawumbi imiphumo emibi ehambelana nokusetyenziswa kwe-statin ayiqhelekanga ngokwaneleyo xa uyiqhathanisa nezibonelelo.
Ukuba umboneleli wakho wempilo unika ama-statins njengomlinganiselo wokuthintela, qiniseka ukuba bobabili unayo yonke inkcazelo oyifunayo, kubandakanywa iziphumo ezintsha, ukwenza isinqumo esinolwazi.
Imithombo:
I-Armitage J. Ukhuseleko lwama-statins ekwenzeni klinikhi. Lancet . 2007; 6736 (07): 60716-8.
UDenus S, uSpinler SA, uMiller K, et al. Izitatimende kunye nesibindi sesibindi: uhlalutyo lwe-meta. Pharmacotherapy . 2004; 24 (5): 584-591.
UHarper CR noJacobson TA. Inkalo ebanzi ye-myopathy ye-statin: ukusuka kwi-myalgia ukuya kwi-rhabdomyolysis. Curr Opin Lipidol . 2007; 18 (4): 401-08.
Jacobson TA. Ukhuseleko lweStatin: izifundo ezivela kwizicelo zamachiza ezitsha zamashishini athengisiweyo. InguJ Cardiol . 2006; 97 (8A): 44C-51C.
I-Spencer B. Imeyili Yemihla ngemihla: Izigulane ezempilo zisebenzisa iiNkcazo zinokwenzeka ngakumbi ukuba zihlupheke kwi-Side-Effects kunokufumana izibonelelo zezempilo '