Ulwalamano oluMngcipheko weDrug, oluchazwe
Ukuba uthatha imithi ye-statin ukuphatha i-cholesterol ephezulu, kuxhomekeke kulowo umiselweyo, ugqirha wakho okanye umseli-mveliso unokugxininisa ukuba akufanele udle iidifruit okanye uphuze ijusi yamagilebhisi xa usesikhatheni. Nangona oko kunokuzwakala ngokungqalileyo-kutheni kungekhona i-orange juice okanye i-lemonade-kunesizathu esihle kakhulu sokususa ngokucacileyo kwesi sikhulu se-citrus.
I-Grapefruit inokusebenzisana nemimiselo ethile ngeendlela ezenza ukuba amayeza angasebenzi kakuhle kwaye aze enze ezinye iziphumo ezingathandekiyo.
Kutheni i-Grapefruit kunye ne-Statins Musa ukuxuba
Kwizonyango, ama-statins ayaziwa njenge-HMG-CoA iyanciphisa i-inhibitors, isigama-magama esichaza kakuhle indlela abasebenza ngayo ukunciphisa amazinga e-cholesterol-ngokuthintela i-enzyme ebalulekileyo ekuveliseni i-cholesterol emzimbeni obizwa ngokuba yi-HMG Co-A yokunciphisa. Iimpawu zezona zinto zichazwe kakhulu kwi-cholesterol-downing medication kuba, ngaphezu kokuvimbela i-cholesterol, ichaphazela zonke iinkalo zeprofayili yakho yeepidid (i-lipoproteins ephantsi, okanye i- LDL ; i-lipoproteins ephezulu, okanye i- HDL ; kunye ne- triglycerides ) ngendlela efanelekileyo .
I-grapefruit iqukethe i-compound ebizwa ngokuthi i-bergamottin edibanisa nenani leenkqubo ze-enzyme emzimbeni, kuquka i-cytochrome P-450 kunye ne-P-glycoprotein. Ezi nkqubo ze-enzyme zinoxanduva lokuphula phantsi i-statins (kunye nezinye iziyobisi) kwiikhemikhali umzimba ongasebenzisa ngokulula.
Ukuba udla iidipefruit okanye utywala i-juice ye-grapefruit xa uthatha i-statin, i-bergamottin inokuyithintela le nkqubo ye-enzyme ukuba ingaphuli iyeza. Ngenxa yoko, inokuqokelela ngexabiso elikhulu emzimbeni wakho.
Ukwakhiwa kweemimiselo ezinobungozi kunokuba yingozi kakhulu, ezinokubangela iingxaki zempilo ezinjenge-enzyme ezinobindi ezinobungakanani okanye imeko engavumelekanga ebizwa ngokuba yi-rhabdomyolysis apho izicubu ze-muscle zehla, ukukhulula iintambo ze-muscle zibe negazi ezinokulimaza iinjongo kwaye zize zenze umonakalo wentliziyo.
Akunabo bonke i-statins abahambelaniyo needrafruit, kodwa ezo zibandakanya:
- Lipitor (atorvastatin)
- Mevacor (lovastatin)
- Zocor (simvastatin)
Ezinye iimimiselo azibonwanga ukuba zinengxaki xa zidibaniswa needrafruit. Iingcali zesazi zicinga ukuba oku kungenzeka kukuba azigqitywanga ziinkqubo ezifanayo ze-enzyme ezijongene neziyobisi. Ziquka:
- Crestor (rosuvastatin)
- Pravachol (pravastatin)
- Lesco (i-fluvastatin)
- Livalo (pitavastatin)
Ngona iJaji elincinci lingase libe lukhulu kakhulu
Izifundo ezininzi zibonise ukuba kuthatha i-ounce enye kuphela ekhonza i-juice, okanye i-grapefruit epheleleyo, ukuze i-statins iqokelele emzimbeni. Ngaloo ndlela, ukuba uthatha i-Lipitor, i-Mevacor, okanye i-Zocor kukulungele ukucima i-grapefruit ngokupheleleyo. Ukuba uyayithanda iminqweno yamagilebhisi kwaye uyayithiya ingcamango yokuyinikela, xelela umboneleli wakho wezempilo ngokukutshintshela kwenye i-statin okanye ubuncinane ukunciphisa umthamo womntu owathathayo. Ngaloo ndlela, uya kukwazi ukunandipha iidirefruit zakho kwaye ungakhathazeki kwimiphumo emibi. Kungaba yinto efanelekileyo ukuba uqaphele ukuba uthatha elinye i-statin ngokungasebenzisi i-grapefruit kwiiyure ezimbalwa ngaphambi okanye emva kokuba uthathe le nyeza.
> Imithombo:
> Dipiro JT, Talbert RL. I-Pharmacotherapy: Indlela yePathophysiological , 9th 2014.
> Lee JW, Morris JK, Wald NJ, et al. "IJupefruit Juice ne-Statins." Am J Med 2016; 129: 26-29.
> IPhalamende le-Vaquero, iSanchez Muniz FJ, iRedondo SJ et al. "Iindlela eziphambili zokusebenzisana kwezidlo ezichaphazela iziganeko zobuKhineli kunye neZakhiwo ze-Hypolipidemic Statements." INutr Hosph 2010; 25: 193-206.