I-Statin Drugs Kwangathi Yenza I-Gene ivuselele Ubuhlungu Bamahlunu
Iitatimins ziyinxalenye yee-anti-cholesterol-downing medications ezisebenza ngokuthintela iprotheni eyintloko, i-HMG-CoA iyanciphisa, enoxanduva lokwenza i-cholesterol kwisibindi. La machiza asebenzayo ekunciphiseni imivimbo kunye nokuhlaselwa kwentliziyo.
Izigidi zabantu baseMelika zithatha iifimethi kuba zijolise ngempumelelo zonke iinkalo zepropid profile yakho ngokunciphisa i-cholesterol ye- LDL kunye ne- triglycerides ngelixa iphakamisa i-cholesterol ye- HDL .
Nangona kunjalo, njengamachiza amaninzi, kukho iziphumo ezinobungozi.
Imiphumo emibi yeemimiselo iquka:
- intlungu yesisu njengento echaphazelekayo yecala
- ukwanda kwendlela yokuvelisa i-enzymes kwisibindi njengempembelelo yecala
- umonakalo wesisu kunye nesibindi njengesiphumo esingaqhelekanga
- iingxaki zokugaya ukutya, kuquka negesi, isifo sohudo okanye isicupuchelelo, njengesiphumo esingaqhelekanga sempembelelo
- ukwanda kwishukela yegazi, ezinokubangela ukuphuhlisa uhlobo lwesifo sikashukela, luyingozi encinane, kodwa ingozi
- Iziphumo ezichaphazelekayo zegazi, kuquka ukulahleka kwememori kunye nokudideka, sisixwayiso esivela kwi-US Food and Drug Administration ebonakala kwiilebula ze-statin
Igalelo eliPhezulu leeNkcazo yiMiscle Pain
Amaphesenti angama-5 ukuya kwe-10 kwizigulane ezithatha ama-statins amava emiphumo echaphazelekayo ekliniki, ephakamileyo kuneengxelo zangaphambili. Iimpawu zingabonakala kwiinyanga ezintandathu zokuqala unyango okanye zivele emva kweminyaka emininzi.
Xa kuziwa intlungu ye-muscular, iziphumo ezichaphazelekayo zinokusukela ekubeni buthathaka obunzima obunobungozi obusongela ubomi obunobomi , obunqabile.
Umngcipheko wakho wokulimala kwemisipha ngexesha uthabatha imimiselo kuxhomekeka kwiimeko ezahlukeneyo, kuquka:
- ungaphezu kwama-80, isetyhini, okanye uncinci
- ukusela i-juice
- ukungcola okanye ukusela ngokweqile
Uphando olupapashwe kwiphepha le-2016 le-New England Medical Journal lubonisa ukuba i-myopathies echaphazelekayo ye-statin i-statin iyakubangelwa yimigangatho yesigxina.
Ukuxhatshazwa kwemisipha engathandekiyo kwaye kuyabonakala kwiqhekeza yezigulane.
Isizathu sokuba kutheni i-Statins ibangela ubuhlungu besisu
Izifundo zangaphambili zibonisa ukuba i-gene isrogin-1 iphendukela kwiinqanaba zokuqala zokuphazamiseka kwemisipha (ukuchithwa kwemisipha), ehambelana nezifo ezifana nomhlaza , i- sepsis , ne- AIDS . Xa i-gene ye-atrogin-1 ingasebenzi, ukutshabalalisa imisipha ayikho.
Izazinzulu eBheteli yakwa-Deaconess Medical Centre eBoston, eMassachusetts zivakalelwa ukuba i-atrogin-1 ingaba negalelo ekuphuhliseni i- myopathies kulabo bathatha ama-statins. Ukuvavanya oku, abaphandi banikela i-statin, i- Mevacor (lovastatin) , kwiiyununu ze-muscle, iintlanzi ze-zebra kunye nabantu.
Abaphandi bafumanise ukuba abantu bathatha i-lovastin banamanqanaba aphezulu e-atrogin-1 kunokuba abo bangathathi iyeza. Ngaphezulu iMevacor inikwe iiseli kunye neentlanzi zentlanzi, mhlawumbi kwakukho ukulimala kwemisipha okwenzekayo. Xa i-atrogin-1 isuswe kwiiseli, le mveliso ayizange ibangele umonakalo wemisipha.
Olu lwazi luqala, kodwa lunikeza ukuqonda oko kunokubangela ubuhlungu besifo kubasebenzisi beempawu, kwaye kutheni abanye abantu bathatha ama-statins banokuthi banokubakho ngaphezu kwalowo.
Kwixesha elizayo, oku kungavumela umboneleli wakho wezempilo ukuba azibonele ukuba usemngciphekweni we- myopathies enxulumene nesimo somntu , ukususela kwiintlungu zengxube emnyama ukuya kwi- rhabdomyolysis yobungozi .
Ukongezelela, izazinzulu ziyakwazi ukulawula lo mfuzo, okanye abanye ababandakanyekayo, ukukhusela umonakalo we-muscle obangelwa yimimiselo.
Imithombo:
Hanai JI, Cao P, Tanksale P, et al. I-ubiquitin e-ubiquitin ethi-ligase i-atrogin-1 / MAFbx idibanisa i-muscle ye-muscle toxicity. J Clin Invest. 117 (12): 3940-3951.
Mammen, Andrew. I-New England Medical Journal Yonyango: I-Statin-Associated Autoimmune Myopathies (2016)
I-Clinical Mayo: I-Statin Side Effects - Ukunyusa iiNzuzo kunye neengozi (2013)