I-Cholestyramine i-cholesterol-downing drug ekwahlukileyo kwe-bile acid kwiklasi yeyeza. Izifundo zibonise ukuba i-cholestyramine iyanciphisa i-cholesterol ye- LDL malunga ne-15%. I-Cholestyramine ayibonakali ibe neempembelelo kwezinye iinkalo zeprofayili yakho yeepidid kodwa ingakwandisa amanqanaba e-triglyceride kwezinye iimeko.
I-Cholestyramine iye yaboniswa ukuba iphucule ukuqhubela phambili kokuphuhliswa kwe-atherosclerosis kwizifundo ezimbalwa.
Nangona kunjalo, akubonakalwanga ukukhusela ukufa okanye ukukhubazeka ngenxa yesifo senhliziyo.
I-Cholestyramine yavunywa kuqala ukuba isebenziswe yi-Food and Drug Administration ngo-Agasti ka-1973 phantsi kwegama legama, i-Questran. Ukususela ekuvunyelweni kwayo kokuqala, kwafunyanwa kwakhona phantsi kwamagama oorhwebo, ama-Locholest, nabanye.
Usebenza njani u-Cholestyramine?
I-Cholestyramine ibophelela kwi-bile acids kumathumbu amancinci, ukukhusela ukubuyisela kwakhona. I-bile acids ivela kwi-cholesterol kwaye iyafuneka ukukunceda ngokugaya amafutha asetyenziswa ekudleni kwakho. Xa i-cholestyramine ibophelela kwi-bile acids, iyancipha kwaye ayiyi kubuyiselwa kwakhona. Ukwenza i-bile acid acids, i-cholesterol iya kususwa kwigazi kwaye iguqulelwe ibe yi-acid acids. Lo msebenzi unciphisa amaqondo akho e-cholesterol.
Ungayifumana njani i-Cholestyramine?
Ufanele uthathe i-cholestyramine njengoko ilawulwa ngumboneleli wakho wezempilo.
I-Cholestyramine ifumaneka kwifomally, ifakwe kwiipakethi ezincinci, kwiipakethe ezinkulu.
Umboneleli wakho wezempilo unokukuqala kumanani amancinci kwaye wandise umthamo wakho ngokusekelwe kwimpendulo yakho kwiyeza kunye nemiphumo emibi. I-dose yokuqala ephakanyisiweyo yinto eyodwa okanye ipakethe (4 grams cholestyramine) kanye okanye kabini ngosuku.
Oku kunganyuswa ukuya kumaxesha amathandathu ngosuku. Idiza kufuneka ixutywe kunye ubuncinane nama-ounces ama-2 yamanzi, isiphumo sesithelo (kunye okanye ngaphandle kwe-pulp), i-appleauce, isobho esincinci, okanye esinye isiphuzo ngaphambi kokutya. Kufuneka uginye konke okuphakathi kwesiselo esine-cholestyramine ukuze ufumane umthamo opheleleyo weyeza. I-Cholestyramine kufuneka ithathwe ngokutya.
Ngubani Akufanele Awuthabathe?
Ngenxa yamacandelo ayo, kukho ezinye iimeko apho kungabikho ukuthatha i-cholestyramine. Ezi ziquka:
- Abantu abaye bafumana isisombululo sokwenyuka kwe-cholestyramine okanye nayiphina i-components yayo akufanele ithathe i-cholestyramine.
- Nabani na oye wafumanisa ukuba unesithintelo se-biliary, apho i-bile acids ayifihliwe emathunjini amancinci.
Iimeko ezifuna ukuba zijongwe
Ukuba uthatha i-cholestyramine, umniki-nkonzo wakho wezempilo unokufuna ukubeka iliso ngakumbi xa unemibandela ethile yezokwelapha ezinokugqithiswa ngokuthatha iyeza. Ukuba unemiqathango elandelayo ingezantsi, umniki-nkonzo wakho unokwenza isigqibo sokukuqala kwi-cholestyramine kodwa uya kufuna ukubeka iliso kuwe ukuqinisekisa ukuba okanye ukungathathi i-cholestyramine kuya kuba yingozi kuwe.
Ezi meko zonyango zibandakanya:
- Amanqanaba aphezulu e-triglyceride. I-Cholestyramine iboniswe ukwandisa amanqanaba e-triglyceride kwizifundo. Ukuba unesi-triglycerides ephakamileyo, umboneleli wakho wezempilo uya kujonga amanqanaba akho ukuqinisekisa ukuba ayenzi phezulu.
- Ukuqhenywa okungapheliyo. I-Cholestyramine ingadlukisa le meko xa unobungozi.
- Ukukhulelwa. I-Cholestyramine ibalwa njengeCandelo lokukhulelwa C. Nangona akuzange kubekho uphando olunzulu oluhlola ukusebenza nokukhuselwa kwe-cholestyramine kwabasetyhini abakhulelweyo. Ekubeni le nkunkuma inganciphisa ukuxutywa kwamanye amavithamini, ezinye izakhi zamavithamini angaphantsi kokuzalwa azange zisebenze ngelixa zithatha i-cholestyramine. Umboneleli wakho wezempilo uya kwenza isigqibo sokuba ngaba ungayifaki le nkunkuma.
Imiphumela
Ukutyunjwa kuyona nto ifanelekileyo echaphazelekayo xa uthatha i-cholestyramine. Oku ngokuqhelekileyo kuhamba kunye no kunyango oluqhubekayo. Umboneleli wakho wezempilo unokugqiba isigqibo sokunciphisa umthamo wakho okanye ukunika unyango ukuba uphathe isigxina sakho ukuba iziphumo zecala ziba nzima kakhulu. Ezinye iziphumo eziqhelekileyo ziquka:
- Ukuqhawula
- Flatulence
- I sizathu
- Ukuxhamla
- Ukuvutha
- Iintlungu zesisu kunye nokuphazamiseka
Ezinye iziphumo zempembelelo ziye zabikwa ngenxa yokusetyenziswa kwexesha elidlulileyo lwe-cholestyramine. Ukwandiswa kwamathuba okuphuma kwegazi kunokuqatshelwa ngokuhamba kwesikhathi ngenxa yokunciphisa iVithamini K. Ukongezelela, utshintshile kwi-enzyme yesibindi kunye nokukhukhula kwe-eyoti yamazinyo kungenzeka ngenxa yokusela ixesha elide lomveliso okanye ukugcina umlomo wakho umlomo.
Ulwalamano olunxulumene
Ezi zi yobisi zilandelayo ziyakwazi ukusebenzisana ne-cholestyramine ngokunciphisa inani lemithi echithwe kwigazi lakho. Umkhiqizi uncoma ukuba angathathi nawaphi na amachiza okanye ancedise ubuncinane iyure enye phambi kweyure okanye iiyure ezingama-6 ukuya kwe-6 emva kokuthatha i-cholestyramine. Ukuba unyanzelekile ukuba uthathe esinye sezidakamizwa okanye isongezelelo esibhalwe apha ngezantsi, umboneleli wakho wezempilo unokufuna ukulungelelanisa i dose okanye ixesha othabathayo, ukubeka iliso ngakumbi kwimiphumo emibi, okanye ukuyeka ukusetyenziswa kwakho konke ndawonye:
- Hormone yeTyroid
- Lanoxin (digoxin)
- Iipilisi zokulawula inzala
- Imithi yokunciphisa i-Cholesterol (kuquka i-fibrates, i-ezetimibe, i-statins)
- Ama-antistroidal anti-inflammatory agents (NSAIDs)
- Corticosteroids
- I-Diuretics (kuquka i-hydrochlorothiazide, i-spironolactone, i-furosemide)
- Coumadin (warfarin)
- Iivithamini ezinamafutha (iivithamini A, D, E, kunye neK)
- Amachiza okuthintela, njenge-Dilantin (phenytoin) kunye ne-phenobarbital
Kukho amanye amachiza amaninzi anokuphinda asebenze kunye ne-cholestyramine, echazwe ngasentla. Ngako oko, kufuneka wenze ukuba umboneleli wakho wezempilo anikezele ngamachiza amiselweyo nangaphezulu, kunye nemveliso yemvelo oyithathayo. Oku kuya kunceda umboneleli wakho wezempilo ukuba azibonele nayiphi na intsebenziswano phakathi kwe-cholestyramine kunye nezinye iyeza.
Okukwintsusa
I-Cholestyramine yenye yeyeza lokuqala zokunciphisa i-cholesterol evunyiweyo e-US. Ngokuqhelekileyo kusetyenziselwa ukunciphisa i-cholesterol yakho ye-LDL kodwa ingaboniswa ngokucacileyo ukuvelisa ukufa okanye iingxaki ezivela kwisifo senhliziyo njengesinye imithi yokunciphisa i-lipid kwimarike. Umele uvumele umboneleli wakho wezempilo ukuba azibonele ukuba unobungozi bokuthatha i-cholestyramine ekubeni ifom edibeneyo ingaba nefuthe elimnandi elinokuba nzima ukugwinya abantu abathile. Ngenxa yokuba i-cholestyramine ifuthe kuphela kwizinga lakho le-cholesterol ye-LDL, umniki-nkonzo wakho wezempilo unokugqiba ukongeza ezinye iindlela zokwelapha - njenge- statin okanye i- fibrate- kwi-regim-downing regimen.
Imithombo:
I-Prevalite (Cholestyramine). I-Upsher-Smith Laboratories. Maple Grove, MN. Ebuyekeziwe 4/2015.
UDipiro JT, uTalbert RL. I-Pharmacotherapy: Indlela yePathophysiological, 9th 2014.
Micromedex 2.0. I-Truven Health Analytics, Inc. iGreenwood Village, CO. Itholakala kwi-http: //www.micromedexsolutions.com.