Ukuba i-cholesterol yakho iphakamileyo, umboneleli wakho wezempilo unokugqiba ekubeni ungeze i-bile acid sequestrant kwi-regimen yokunciphisa i-cholesterol. I-Bile acid sequestrants, eyaziwayo njenge-resin acid ye-bile okanye i-BAR, yinkalo yemichiza esetyenzisiweyo ekuncedeni ukunciphisa amazinga e-cholesterol. Okwangoku, amayeza amathathu kule nkcazo yeziyobisi ayatholakala eUnited States:
I-Welchol (colesevelam) ifumaneka njengepilisi okanye i-resin powder. I-colestid (colestipol) kunye neQuestran (cholestyramine) zifumaneka kuphela njenge-powin resin.
I-Acil Acid Sequestrants I-Bile iyanciphisa njani i-Cholesterol yakho?
La machiza asebenza ngokubophelela kwi-bile acids kunye nokukhusela i-bile acids emathunjini amancinci. Esikhundleni sokungena kwigazi, ukudibaniswa kwe-bile acids kunye neziyobisi zixutywe emanzini. Ekuphenduleni kokunciphisa i-acid ye-bile emzimbeni, isibindi sakho siza kuguqula i-cholesterol ibe ne-bile acids. Ukongezelela, ii-receptors ze-LDL ziya kwandiswa kwinobindi. Ezi zenzo zinceda ukunciphisa izinga le-cholesterol egazini.
Ngenxa yoko, i-bile acid sequestrants ikakhulu i-cholesterol ye- LDL ephantsi kwe-15% ukuya kwi-30% kwaye iphakamisa i-cholesterol ye- HDL ngokukhawuleza malunga ne-3% ukuya kwi-5%.
Ezi ziyobisi azibonakali zichaphazela amanqanaba e- triglyceride kodwa, kwezinye iimeko, i-bile acid sequestrants ingakwazi ukuphakamisa i-triglycerides yakho xa ithathwa ixesha elide.
Ngenxa yokuba abazange baqinisekiswe ukuba banciphise umngcipheko wokuhlaselwa yintliziyo okanye ukubetha, i-bile acid sequestrants ayinqunywanga ngokuqhelekileyo njengenye imithi yokunciphisa i-cholesterol, ngakumbi i-statins. Nangona kunjalo, zinokuthathwa zodwa okanye zidibaniswe nezinye iyeza zokunciphisa i-cholesterol ukukunceda ukulawula amanqanaba akho eepidid.
Iimiphumo eziqhelekileyo zamacandelo ama-Acid sequestrants
Imiphumo emibi ekuthatheni i-bile acid sequestrants ininzi iquka iingxaki zesisu, kuquka:
- I sizathu
- Ukutyunjwa
- Ukuqhawula
- Flatulence
Imiphumo emibi ingaphathwa ngokunyusa ukungena kwamanzi, ukuthatha isilathisi se-stool okanye ngokufaka i-fiber kwisondlo sakho.
Abanye abantu banokufumana kunzima ukuhlala ngokuthatha i-bile acid sequestrant yabo. Ngokomzekelo, abanye abantu banokufumana i-resins ibe yinyameko yokunambitha - ngakumbi ukuba kufuneka ithathe ixesha elingaphezu kweyodwa ngosuku. Nangona kukho iindlela zokuphucula intlawulelo yamanzi, ezinye zithatha isibisi asikwazi ukunyamezela intle yabo. Ukongeza, i-Welchol ithebhulethi inkulu kwaye ingaba nzima ukugwinya abanye abantu. Ukuba unikwe i-bile acid sequestrant kwaye unobunzima ukuthatha amayeza akho, kufuneka uvumele umboneleli wakho wezempilo ukuba azi oku.
Ngubani Akufanele Athathe I-Acid Sequestrant?
Ngaphandle kokubhengeza imbali yakho epheleleyo yezokwelapha, kufuneka uxelele nomboneleli wakho wezempilo ukuba unayo nayiphi na le meko yonyango engezantsi:
- Ukuba sele sele unamazinga aphezulu kakhulu e-triglyceride okanye owake wafumana imicimbi yezobugqirha ngenxa ye-triglycerides ephezulu kakhulu, njenge-pancreatitis. Oku kubangelwa kukuba i-bile acid sequestrants ingaphakamisa amanqanaba akho e-triglyceride.
- I-Bile acid sequestrants ingasebenzisana namanye amavithamini okanye amanye amayeza owathathayo. Ngoko ke, kufuneka uxelele bonke ababoneleli bezempilo ukuba uthatha i-bile acid sequestrant ukwenzela ukuba banokuqiniseka ukuba izidakamizwa azihambelani naluphi na amanye amayeza, iivithamini, okanye izongezelelo ezithathayo. Kwezinye iimeko, umboneleli wakho wezempilo unokucela ukuba ukwandise inani lexesha phakathi kokuthatha i-bile yakho ye-acid sequestrant kunye namanye amayeza.
- I-Bile acid sequestrants ayinakufundiswa kwabasetyhini abancancisayo okanye abakhulelweyo. Nangona i-bile acid sequestrants ayibonakali ukuba iwele kwigazi, inokunciphisa ukufunyanwa kwamavithamini athile abalulekileyo.
- Ukuba unemiqathango yesisu, njengama-hemorrhoids okanye ukuqothulwa, ukuthatha i-bile acid sequestrants kungenza kube nzima le miqathango. Ukongezelela, kufuneka uvumele umnonophelo wakho wezempilo ukuba wazi ukuba unomqobo wokukhusela.
Umboneleli wakho wezempilo uya kubava amanqaku kunye neengozi zokumisela i-bile acid sequestrant kuwe kwezi ziko ukukunceda ukulawula i-lipids yakho.
> Imithombo:
> Dipiro JT, Talbert RL. I-Pharmacotherapy: Indlela yePathophysiological, 9th 2014.