I-Welchol (i-colesevelam) yipilisi ye-cholesterol-eyanciphisa iyeza ye-bile acid ye-drug class. Ucwaningo luye lwabonisa ukuba i-Welchol ngokuyinhloko ihlisa i-cholesterol ye- LDL malunga ne-20% kwaye iphakamisa i- HDL ngokukhawuleza ibe yi-11%. I-Welchol ayibonakali iyichaphazela i- triglycerides kwaye, kwezinye iimeko, inokwenene ivelise i-triglycerides ukuba ithathwa ixesha elide.
I-Welchol ikwabonakaliswa kubantu abane-type 2 yeswekile ukuba bancede balawule amazinga e-glucose egazi kunye namakhwenkwe kunye namantombazana angama-postmenarchal ukuya kwiminyaka eyi-10 ubudala efunyaniswa ukuba ne-heterozygous familial hypercholesterolemia.kunceda ekunciphiseni i-LDL ye-cholesterol. Nangona la mayeza aye abonakalise ukuba asebenzayo ekunciphiseni i-LDL, akuzange kuboniswe kwizifundo zokunciphisa ngqo iziganeko zesifo senhliziyo.
I-Welchol ifumaneka kwiifom ezimbini: ifomu eliyimpuphu kunye ne-tablet. Isilwanyana savunywa ukuba sisebenzise e-US yi-FDA ngoMeyi ka-2000.
I-Welchol isebenza njani?
U-Welchol usebenza ngokubophelela kwi-bile acids emathunjini amancinci nokukhusela ukubuyiswa kwawo kwakhona. I-bile acids iphuma kwi-cholesterol kwaye uncedise ukutyalwa kwamafutha okudliwe ngokutya kwakho. I-bile acids iyancipha ngenxa yokubopha kwi-Welchol kwaye ayiyi kubuyiselwa kwakhona. Ngenxa yoko, i-cholesterol iya kususwa kwigazi kwaye iguqulelwe ibe yi-acid acids kwisibindi.
Lo msebenzi ususa i-cholesterol egazini-eyenza i-LDL ye-cholesterol iyancipha.
Ungayifumana njani iWelchol?
Kufuneka uthathe iWelchol njengoko ulandiswa ngumniki-nkonzo wakho wezempilo. Oku kuya kuxhomekeka kwindlela oyithatha ngayo iWelchol.
Ifom ye-Welchol, i-dose ephakanyisiweyo yipakethi ye-3.75-gram yansuku zonke, okanye ezimbini, iipakethi eziyi-1.875 ezithathwe kabini ngosuku.
Kufuneka uchithe okubhalwe kwipakethi kwisigamu esinye okanye enye inkompo yamanzi, soda yokutya, okanye isandi sesithelo kwaye udibanise kakuhle. Zonke iziqulatho zesiselo kufuneka zichithe, ngokubambisana nesidlo.
Iipilisi, i-dose ephakanyisiweyo kukuthatha amacwecwe angama-6 ngexesha elinye, okanye ulwahlulwe ngamaphilisi amathathu kabini ngosuku. Iibhulile kufuneka zithathwe ngokutya kunye neglasi egcweleyo yamanzi.
Ngubani ongafanele athathe iWelchol?
Ngenxa yamacandelo ayo, kukho iimeko apho iWelchol ayifanele ithathwe. Ezi ziquka:
- Abantu abathile abaye baphendukela kwi-Welchol okanye nayiphi na into yayo.
- Nabani na owake wafumana isithintelo somzimba.
- Abantu abathile abane-triglycerides ephezulu kakhulu (ngaphezulu okanye elingana no-500 mg / dL), ekubeni i-Welchol inokunyusa amanqanaba akho e-triglyceride ngaphezulu. Ukongezelela, ukuba uye wafunyaniswa ngaphambili ukuba ube ne- pancreatitis ngenxa ye-triglycerides ephezulu, akufanele uthathe i-Welchol.
Ziziphi Iimeko Eziza Kufuneka Zibekwe Ngqalelo Ngethuba Lithatha iWelchol?
Kukho iimeko ezinokufuna ukuba zijonge ngakumbi xa uthatha iWelchol. Ukuba unemiqathango elandelayo ngezantsi, umniki-nkonzo wakho unokwenza isigqibo sokukuqala kwiWelchol, kodwa uya kufuna ukubeka iliso kuwe ukuqinisekisa ukuba okanye ukuthatha i-Welchol kuya kuba yingozi kuwe.
Ezi meko zonyango zibandakanya:
- Ukuba nobunzima bokugwinya. Iipilisi zeWelchol zikhulu kakhulu kwaye zinokuba nzima ukugwinya ukuba sele sele unemiba.
- Amanqanaba aphezulu e-triglyceride. Ukuba namazinga aphakamileyo aphezulu e-triglyceride akuyi kukubamba ukuba uthathe u-Welchol, kodwa umboneleli wakho wezempilo unokufuna ukubeka iliso i-lipids yakho ngakumbi ukususela ekubeni i-Welchol inokunyusa amanqanaba akho e-triglyceride.
- Iingxaki ezinobungqina bentlungu yakho yesisu. I-Welchol inokubangela ukutyunjwa, ngoko oku kungonakalisa ezinye zeemeko.
- I-Welchol ikwahlula njengeNqanaba lokukhulelwa uB . Nangona akuzange kubekho uphando olunzulu oluhlola ukusebenza nokukhuseleko kwe-Welchol kwabasetyhini abakhulelweyo, izifundo zezilwanyana azibonanga kakubi kumntwana. Ekubeni le nkunkuma inganciphisa ukuxutywa kwamanye amavithamini, ezinye izakhi zamavithamini angaphantsi kokuzalwa azange zisebenze ngelixa zithatha iWelchol. Umboneleli wakho wezempilo uya kwenza isigqibo sokuba ngaba ungayifaki le nkunkuma.
Ziziphi iimpembelelo ezimele ndimele ndizilindele ngoxa ndithatha u Welchol?
Imiphumo yesisu esisisigxina yizona ziphumo eziqhelekileyo ezichaphazelekayo xa usebenzisa i-Welchol. Ezi ziquka:
- Ukuqhawula
- Ukuguquka
- I sizathu
- Ukunyanzelisa
- Ukutyunjwa
- Intlungu zesisu
Ezinye iziphumo ezichaphazelekayo, ezifana nobuhlungu be-muscle kunye nomqala wengqondo, nazo ziye zabikwa kwizifundo. Ukuba ezi ziphumo zecala ziba nzima, kufuneka uvumele umboneleli wakho wezempilo ukuba azi. Unokukunika into yokuphatha umphumo wecala, ulungise umthamo wakho, okanye ukutshintshela kwenye iyeza ye-cholesterol.
Yiyiphi imithi ekwazi ukusebenzisana noWelchol?
La machiza alandelayo angabelana noWelchol ngokunciphisa inani lemithi echithwe kwigazi lakho. Njengomthetho, mhlawumbi ingumzekelo omuhle wokungathathi nawaphi na amachiza okanye ukongezelela iiyure ezine ngaphambi kweeyure ezithandathu emva kokuthatha nayiphina i-bile acid resin drug, njenge-Welchol. Ukuba unyanzelekile ukuba uthathe esinye sezidakamizwa okanye isongezelelo esibhalwe apha ngezantsi, umboneleli wakho wezempilo unokufuna ukulungelelanisa i dose okanye ixesha othabathayo, ukubeka iliso ngakumbi kwimiphumo emibi, okanye ukuyeka ukusetyenziswa kwakho konke ndawonye:
- Hormone yeTyroid
- Lanoxin (digoxin)
- Iipilisi zokulawula inzala
- IVerapamil
- Metoprolol
- Coumadin (warfarin)
- Iivithamini ezinamanzi ezinqabileyo (iivithamini A, D, E, kunye neK)
- Amachiza okuthintela, njenge-Dilantin (phenytoin) kunye ne-phenobarbital
Oku akulona uluhlu olupheleleyo, ngoko kufuneka uqinisekise ukuba uchaza yonke imishanguzo emiselweyo nangaphezulu, kunye nemveliso yemvelo oyithathayo. Oku kuya kunceda umboneleli wakho wezempilo ukuchonga nayiphi na intsebenziswano phakathi kwe-Welchol kunye nezinye iyeza.
Okukwintsusa
I-Welchol yipilisi esetyenziswa kakhulu ukunciphisa i-cholesterol yakho ye-LDL kodwa ayizange iboniswe ukunciphisa isifo senhliziyo kwisifundo. Ukongezelela, ngenxa yokuba ifom ephuhliweyo ye-Welchol inokunyanzeliswa kwintlungu yakho kwaye iipilisi ezinokuba nzima ukugwinya, kufuneka uvumele umboneleli wakho wezempilo ukuba azibonele ukuba unengxaki nayiphi na i-Welchol. Ngenxa yokuba i-Welchol ithintela kuphela iindawo ezithile zeprofayili yakho yeepidid, umboneleli wakho wezempilo unokufuna ukongeza ezongezelelweyo zokwelapha ezinjenge-lipid-efana nesimo se- statin okanye i- fibrate .
Imithombo:
UDipiro JT, uTalbert RL. I-Pharmacotherapy: Indlela yePathophysiological, 6th 2005.
ULacy CF, u-Armstrong LL, i-Goldman MP, kunye no-al. I-Lexicomp ye-Drug Information Handbook, ngomhla we-15 ku-2007.