Iifibrate, ezibizwa ngokuba yi-fibric acid derivatives, ziyi-classic-downing drugs ekwazi ukuphazamisa yonke imiba yepropid profile yakho.
Indlela leyo i-fibrates ephantsi ye-cholesterol inzima. I-Fibrate isebenze iprotheni ebizwa nge-peroxisome ene-actor receptor alpha (PPAR-alpha). Le prothini inokusebenzisa enye i-enzyme, i-lipoprotein lipase, eyanciphisa inani le- apolipoprotein C-III emzimbeni.
Ekugqibeleni, oku kuphumela ekunciphiseni ukubunjwa kweVLDL kunye ne-triglycerides kwaye kwandisa ukuphuka kweepids. AmaFibratsayo akhula nakwizinga le- HDL ngokunyusa inani le- apolipoprotein AI kunye ne-A-II eyenziwa emzimbeni.
Kukho okwamanje iifayile ezimbini ezivunyelwe ukusetyenziswa yi-Food and Drug Administration (FDA) eUnited States:
- Gemfibrozil (Lopid)
- Fenofibrate (Tricor)
Iifibrate ziyaziwa ngokunciphisa i-triglycerides kunye nokwandisa i-cholesterol ye-HDL. Nangona kunjalo, zinokuchaphazela yonke imiba yepropid profile yakho. Ngokubanzi, iifayile ziya:
- Nciphisa ama-cholesterol akho e-LDL ngamaphesenti ama-5 ukuya kuma-20 ekhulwini.
- Ukwandisa i-cholesterol yakho ye-HDL yiphina phakathi kweepesenti ezili-10 ukuya kuma-35 ekhulwini.
- Nciphisa amanqanaba akho e-triglyceride ngama-20 ekhulwini ukuya kuma-50 ekhulwini.
Ukuze uphucule ngempumelelo iprofayili yakho yefayili, i-fibrates ingathathwa yedwa okanye idibaniswe namanye amanxeba ahlambulukileyo e-lipid, afana namanqatha okanye i-omega-3 fatty acids.
Indlela Ofanele Uyenze Ngayo I-Fibrate
Kufuneka uthathe i-fibrate yakho ngokuchanekileyo njengoko kuchazwe ngumboneleli wakho wezempilo kwaye kufuneka uqiniseke ukuba ungaphuthelwa nayiphi na imilinganiselo. Yonke imithi ye-fibrate ifumaneka kwifom yefomathi kwaye ithathwa ngomlomo. Nangona ungathatha zombini iintlobo ze-fibrates okanye ngaphandle kokutya; Nangona kunjalo, uphando lubonise ukuba ukuthatha i-fibrate, i-gemfibrozil, kunye nesidlo kunceda ukwandisa ukutshatyalaliswa kwayo.
Kufuneka uqinisekise kwakhona ukuba ungaphuthelwa naluphi na umntu otyunjweyo kunye nomboneleli wakho wonyango, kuba uya kufuneka ukuba aqaphele ukuba ingekho iyeza. Umboneleli wakho wezempilo unokufuna ukulungiswa kwipilisi yakho yokunciphisa i-lipid, kuxhomekeke kwindlela ophendula ngayo kwiyeza. Ngoxa uthabatha i-fibrate-okanye nayiphina indlela yokwelapha i-lipid-yehlisa unyango - kufuneka ulandele ngokulandelelana ukutya ukuze unciphise i-cholesterol yakho kunye ne-triglycerides.
Ngaba zikhona naziphi na iziphumo ezifunekayo ofuna ukuzijonga?
Nangona i-fibrate ixhomekeke kakuhle kubantu abathathayo, unokuba neempembelelo ezibangelwa ukuzithatha, iziphumo eziqhelekileyo ezichaphazelekayo zibandakanya kubandakanywa nemiba yesisu, njengentlungu, isifo sohudo kunye nesisu esiswini. Ezi ziphumo zivame ukuba zinyameko kwaye, kwiimeko ezininzi, hamba emva kokuqala i-fibrate yakho.
Kwezinye iimeko, i-fibrates inokunyusa i-enzymes yesibindi sakho, ngoko ke ngaphezu kwe-lipids yakho, umboneleli wakho wezempilo uya kubeka esweni i-enzyme yesibindi ngexesha lakho. Ukuba unesifo se-gallbladder, kufuneka uvumele umnonophelo wakho wezempilo ukuba azi, kuba kukho umngcipheko omncinci wokuphuhlisa i-gallstones ngelixa uthatha i-fibrate. Iifibrathi zinokubangela ukuba imeko ibhekiswe kwi-rhabdomyolysis.
Nangona kunqabile, umngcipheko wokuphuhlisa le meko ngelixa uthatha i-fibrate yanda xa uthatha amanye amayeza kunye ne-fibrate yakho okanye unempilo ethile.
Iifibrate zinokunyusa amathuba okufumana igazi xa uthatha igazi elincinci, njengeCoumadin ( warfarin ). Ngenxa yoko, umboneleli wakho wezempilo unokuthi alungele i dose ngelixa uthatha i-fibrates.
Iimiphumo ezichaphazelekayo ezifakwe yi-fibrate ziqhelekile, kodwa kufuneka ziswe kwingqwalasela yomncedisi wakho wezempilo xa zixhalabisa okanye ziqhubeka ixesha. Umele uvumele umboneleli wakho wezempilo ukuba azi naziphi na iziyeza ozithathayo-kuquka nayiphi na imveliso yemveliso okanye i-over-counter-counter-or medical conditions ukuba unako ukukubeka iliso ngokuthe xaxa ngexesha lonyango.
Imithombo:
> Dipiro JT, Talbert RL. I-Pharmacotherapy: Indlela yePathophysiological, 9th 2014.
Malloy MJ, Kane JP. Amagunya asetyenziswa kwiDyslipidemia. Ku: Katzung BG, Trevor AJ.eds. I-Basic & Clinical Pharmacology, 13e . New York, NY: McGraw-Hill; 2015.