Ukutya, amayeza kunye nokuchaphazela ama-dosfarin dosages
Ukuba uye waphathwa nge- thrombosis enzulu , ungalindela ubuncinane iinyanga ezintathu ze-anticoagulants okanye iyeza lokunciphisa igazi emva kokuphuma esibhedlele.
I-thrombosis engummangaliso iyingozi apho umzimba wakho udala i-clot, ngokusemandleni emlenzeni, onokuphosa ezinye iiplanga ezenza ukuba ujikeleze kwimipuphu yakho.
Isiganeko esibulalayo siyaziwa njenge- pulmonary embolism. Xa unyango lwe-antiticoagulant oluqhubekayo emva kokuba ushiye esibhedlele, unciphise umngcipheko wokuguqula loo macala egazi. Ingqalelo, i-anticoagulant therapy ayinikezwa nje kuphela nge-thrombosis enzulu. Ngokomzekelo, ukuba ngoku uphathwa unyango ngenxa yesifo okanye unobungozi obungasetyenziswayo, unokulindela ixesha lokuphila kwe-antiticoagulation.
I-Anticoagulation ingagcinwa ngamachiza amaninzi kuquka i-heparin yesisindo esisezantsi esingaphantsi (i-injection subcutaneous), i-fondaparinux (i-injection subcutaneous) okanye i-oral Xa inhibitors njenge-dabigatran. Kule ngqaku, siza kugxila kwi-warfarin (i-Coumadin) eqhelekileyo ifumaneka njengonyango lomlomo. Xa ukhetha unyango lwe-anticoagulant, nceda ugcine engqondweni ukuba ukhetho lukhona, kwaye ugqirha wakho unokukwazi ukuxoxa ngale ndlela kunye nawe.
Indlela iWarfarin isebenza ngayo
I-Warfarin iphazamisa ubungqina bezinto ezinqamlekileyo ezixhomekeke kwi-vitamin K, ngoko kuphazamisa inkqubo yokwenza i-coagulation kunye nokukhusela ukubunjwa kwamaphiko amatsha.
Ngaphambi kokuba ifikelele, i-warfarin idibene ne-parenteral okanye i-anticoagulant injectable njengeLovenox (inoxaparin injection).
I-Warfarin ifumaneka kumabini amalungiselelo omlomo kunye nama-intravenous-abaninzi abantu bathatha i-warfarin yomlomo. Abantu baqaliswa malunga ne-5 mg yemfazwe yemini ngosuku lweentsuku ezimbalwa zokuqala. I-dose yeWarfarin ihlaziywa ukwenzela ukugcina amanqanaba e-INR, amanyathelo endima ye-coagulation endiyayichukumisa ngayo, ngonyango.
Ukuba unomdla, i-website ethi www.warfarindosing.org inika i-calculator-dose calculator yamahhala.
Ngubani Ofuna Amanani Aphakamileyo?
Izilingo eziphezulu ze-warfarin zingafuneka ukuba iziguli zilandelayo zilandelelwe:
- Afrika yaseMerika
- Akunanto
- Hypothyroid
- Utywala luxhomekeka
Ngubani osweleyo umgangatho ophantsi?
Ngokwahlukileyo, isi sigulane esilandelayo sifanele sithole amanani angaphantsi kwe-warfarin:
- Abadala
- Asia
- Hyperthyroid
- Ukumelwa yintliziyo
- Isifo sesibindi
- Imbali enkulu yokuhlinzwa
- Iipolymorphisms kwi-CYP2C9 okanye i-VKORC1 zegesi
Ukongezelela kwiimpawu zesigulane esingentla ngentla, i-warfarin dosayo iyahlengahlengiswa ngokuxhomekeka kumachiza owathathayo. Ngokomzekelo, i-phenytoin yandisa isenzo se-warfarin kwaye yanciphisa amanqanaba e-INR.
Umlinganiselo we-laboratory INR ( umlinganiselo osemthethweni jikelele) usetyenziselwa ukucacisa isimo sakho se-coagulation kwaye utshintshe umlinganiselo wakho we-warfarin. Kubantu abaninzi, amanqanaba aqhelekileyo e-INR avela kwi-0.8 ukuya ku-1.2. Abantu abakwi-warfarin basoloko begcinwe kwinqanaba le-IN eliphakathi kwe-2 ne-3, oku kuthetha ukuba ezi zi gulane zichaneke kakhulu (zinegazi elincinci) kunabantu abaphakathi. Nangona ufumana i-antiticoagulation, amazinga e-INR kufuneka ahlolwe rhoqo ngugqirha wakho.
Indlela Ukutya Okuchaphazela Ngakanani Isisombululo
Ngenxa yokuba i-warfarin i-vitamin K inxamnye, ukutya okunothile kwi-vitamin K kunokunciphisa amanqanaba akho e-INR.
Ngokukodwa, iifuno eziluhlaza kunye namagqabantshintshi zihlala ziphezulu kwi-vitamin K. Ngakolunye uhlangothi, iifatata, iziqhamo, kunye nezityalo ziphantsi kwe-vitamin K. Unokwazi ukuqhubeka udla izondlo eziluhlaza kunye nemifuno eluhlaza, nangona kunjalo, zama ukuhlala uhambelana ekusebenziseni kwakho imihla ngemihla ukuze amazinga akho e-INR aguquke.
Mngcipheko
Imiphumo emibi yonyango lwe-warfarin ngokuqhelekileyo iyancitshiswa kwi-nasusea, i-cramps njalonjalo. Nangona kunjalo, i-warfarin yandisa umngcipheko wokuba utyhefu okanye ukuphuma kwamanzi okunokuba lukhulu kakhulu (cinga ingqondo yegazi). Xa kunzima ukubola ngenxa yokunyanga kunye ne-warfarin, oogqirha banokulawula i-vitamin K ukuze bancedise okanye bavale igazi.
Abantu abanembali yokuqhwaba kufuneka baqaphele xa bethatha i-warfarin. Ukongezelela, xa uthabatha i-warfarin, kukulungele ukusebenzisa i-razor kagesi kunye ne-toothbrush yamagesi ukuze unciphise umngcipheko wegazi. Kwakhona, qiniseka ukuxelela udokotela wakho wamazinyo ukuba usepilini ngaphambi kokuba nawuphi na umsebenzi wamazinyo owenziwe.
Ngenxa yokuba i-warfarin inokusebenzisana neendlela ezahlukeneyo zamachiza kwaye iphosa amanqanaba akho e-INR ekuhambeni, kuyona nto ibhetele ukuba ugweme amayeza okanye amanxeba encedisayo ngelixa lonyango.
Ukuba wena okanye othandekayo kufuneka uthathe i-warfarin ngenxa ye-thrombosis enobulunga obukhulu, isifo soxinzelelo, okanye imeko e-hypercoagulable, nceda ukhumbule ukuba unyango lwe-anticoagulant kule nkunkuma yinkqubo ebandakanyekayo. Ukuseka nokugcina isimo esifanelekileyo se-antiticoagulation, kuya kufuneka usebenze ngokusondeleyo kunye nogqirha wakho kwaye ngokukhethekileyo u-dietitian, naye. Nceda ukhumbule ukuba uhlale uqaphile, fumana amanqanaba akho e-INR ahlolwe rhoqo, sebenza kunye neqela lakho lonakekelo lwezempilo, kwaye ujonge ngokutya kwakho.
> Imithombo:
> I-Fogarty PF, iMichiichiello T. Iintlungu zeHemostasis, iThrombosis, kunye ne-Antithrombotic Therapy. Ku: Papadakis MA, McPhee SJ, Rabow MW. eds. Ukuxilongwa kweZonyango kunye neNyango ka-2015 . New York, NY: McGraw-Hill; 2014.
> I-Mosby's Drug Reference yeeNkonzo zezeMpilo, Ulohlu lwesiBini. Elsevier ngo-2010.