Umbuzo: Ngaba kufuneka uthathe i-CoQ10 kunye neeNkcazo?
Ugqirha wam undibeke kwi-simvastatin generic ukunciphisa i-cholesterol yam. Ndibonakala ngathi ndibekezelela, kodwa ndivile ukuba ukuba uthatha isicatshulwa se-statin, kufuneka uthathe i-CoQ10 ukukhusela iingxaki ze-muscle. Ngaba kunjalo? Ngaba kufuneka ndibe neCoQ10?
Impendulo: Ngelishwa, akukho mpendulo ecacileyo kulo mbuzo.
Nangona kunjalo, ubungqina bekliniki esimele sibe nomhla bubonisa ukuba i-CoQ10 ayincedi kakhulu, ukuba ngaba, ukukhusela okanye ukuphatha iingxaki ze-muscle kunye neemimiselo .
Yintoni iQoQ10?
CoQ10 - eyaziwa nangokuthi yi-ubiquinone - yinto efana ne-coenzyme eyenza izihlunu zivelise amandla abayifunayo ukwenza umsebenzi wazo. Nangona ezinye izifundo ziphakanyisile ukuba i-statins inokunciphisa inani le-CoQ10 kwiisisipha zomzimba, ezinye iingcali azifumananga ukuhla kwezinga le-CoQ10 kunye namaziko. Ngoko ke umbuzo wokuba ngaba ama-statins angathintela amanqanaba eCoQ10 kuzo zonke azicaci ngokupheleleyo. Kwimeko nayiphi na into, abaninzi baye bacacisa ukuba amanqanaba ancitshisiweyo weCoQ10 angafaka isandla kwi- myopathy (ukulimala kwemisipha) engenzeka ngeemimiselo . Ngoko ke, abanye oogqirha bancoma i-CoQ10 yongezelelo kunye neyeza-statin.
Ubuphi ubungqina kwiCoQ10 kunye neeStinsin?
Uncwadi lwezokwelapha luxutywe kumbuzo we-CoQ10, kunye nezizathu ezibini.
Okokuqala, njengoko kukhankanywe, akukho zonke iifundo ezibonisa ukuba i-statins ithintela amanqanaba e-CoQ10 kumzimba wesisu.
Kwaye okwesibini, izifundo kunye neCoQ10 kubantu abathatha ama-statins baye banqongophala. Izifundo ezimbalwa, ezincinci, ezifutshane zonyaka zigqityiwe, kwaye iziphumo zezi zifundo ezimbalwa zididekile.
Ucwaningo lweklinikhi oluye lwaqhutywa ngoku luye lwahlola ubuchule beCoQ10 ukunyanga ubuhlungu be-muscle.
Injongo yalezi zifundo kwakunokumisela ukuba ukuthatha i-CoQ10 kunokuvumela izigulane zintlungu yesifo se-muscle ukuba ziqhubeke nokuthatha i-statins. Le nto ibalulekileyo, kuba xa kuziwa ekunciphiseni ubungozi benhliziyo ngenxa yamanqanaba e-cholesterol, akukho nto ingenayo indawo efanelekileyo kwiimimiselo .
Ezi zifundo zenze iziphumo eziphikisanayo. Icandelo lezilingo ezingama-32 ezinokubandezeleka kwe-muscle ezibangelwa ngumzimba kubonisa ukuba, emva kweentsuku ezingama-30, abo bafumana i-CoQ10 banokunciphisa ubunzima beentlungu xa beqhathaniswa nalabo abangazange bafumane i-vitamin E. , nangona kunjalo, kuba kuthatha iintsuku ezingaphezu kweentsuku ezingama-30 ze-CoQ10 ukuzalisa ukuchaphazela inani le-CoQ10 kwimisipha ngokwabo. Ukongezelela, iimvavanyo eziliqela ezifanayo, ixesha elide elide kunye neCoQ10 azibonanga ngcono kwiintlungu ze-muscle kwiimimiselo.
Ukuzama ukulungisa umba, uhlalutyo lwe-meta lwenziwe ngo-2015, ukuhlalutya iilingo ezifumanekayo. Olu hlalutyo alufumananga nzuzo enkulu xa i-CoQ10 isetyenziselwa ukuphatha imopathy eyenziwa ngummiselo. Nangona kunjalo, umgangatho wezifundo ezikhoyo zihlala zingumngeni, ngoko ke iziphumo zolu cwaningo-meta alukwazi kuthathwa njengento echanekileyo.
Izilingo ezinkulu, ezangexesha elide ziza kubakho imfuneko ukufumana ingxaki kumbuzo.
Akukho nanye kule nto, nangona kunjalo, ufika kumbuzo wakho, okokuba, ukuba umntu uthatha i-statins nayo ithatha i-CoQ10 ukukhusela i- statin myopathy? Isizathu sokuba ndathetha kuphela ngokusebenzisa i-CoQ10 ukuphatha intlungu yesisundu eyenziwa ngumthetho kukuba kukho ubuncinane idatha ethile ekhoyo ejongene nalo mbuzo (njengokuba kunokwenzeka ukuba loo datha ingabakho).
Kodwa xa kuziwa ekusebenziseni i-CoQ10 njengomlinganiselo wokuthintela, ubungqina obuphela kuphela obukhoyo buyi-anecdotal. Azikho izilingo ezilawulwa ngokungahleliweyo ezijongene nale mibuzo.
I-CoQ10 kunye neeNkethi - Eyona ndawo
Umgca wenyani kukuba akukho bungqina obufanelekileyo, obunobungqina obuvela kwizilingo zeklinikhi ezikhoyo ukubonisa ukuba i-CoQ10 ingavimbela okanye yenza ngokufanelekileyo intlungu ye-muscle. Ngelo xesha, inkolelo yokuba uCoQ10 inokukunceda ihlala isamangalisa, kwaye izifundo ezenziwe zincinci kwixesha kunye nobude balo. Ukongezelela, ukuthatha izongezelelo zeCoQ10 (ngokubhekiselele kunoma ubani owaziyo) ayiyingozi.
Ngoko ukuba unomdla wokuzama, kwaye unako ukuwufumana, oogqirha abaninzi abanakuvakalisa ukuphikisa ingcamango.
Ukuba unesifo se-muscle ngelixa unemimiselo, kufuneka uxoxe nodokotela wakho ngokuzama ukusetyenziswa kwesinye sezidakamizwa ze-statin esaziwayo ukuba akunakwenzeka ukuvelisa iingxaki ze-muscle, okuthi, i-Lescol (i-fluvastatin) okanye iPravachol (pravastatin). Kwakhona, qinisekisa ukuba ugqirha wakho uhlola umsebenzi wakho we-thyroid kunye namazinga akho e-vitamin D, kuba i- hypothyroidism okanye i-vitamin D ephantsi izakwenza i-statin myopathy ibe lula.
> Imithombo:
> Banach M, uSerban C, uSahebkar A, et al. Iimpembelelo zeCoenzyme Q10 kwi-Myopathy eyenziwa yi-statin: i-Meta-analysis of Trials Controled Trials. IMayo Clin 2015; 90:24.
> I-DA ye-Bookstaver, iBrakhalter NA, Hatzigeorgiou C. Impembelelo yeCoenzyme Q10 Ukongezwa kwi-Stal-induced Myalgias. Ngaba uJ Cardiol 2012; 110: 526.
> Caso G, Kelly P, McNurlan MA, Lawson WE. Impembelelo yeCoenzyme q10 kwiimpawu zeMyopathic kwizigulane eziphathwe nge-Statins. InguJ Cardiol 2007; 99: 1409.
> Taylor BA, Lorson L, White CM, Thompson PD. Uvavanyo olungalindelekanga lweCoenzyme Q10 kwizigulane eziqinisekisiweyo zeStatin Myopathy. Atherosclerosis 2015; 238: 329.