Funda iSisiseko se-Antioclonal Antibody Treatment
Ulwaphulo lwe-antioclonal antibody lungumhlaza ojoliswe kuwo . Ngezinye amaxesha kuthiwa yi-immunotherapy. Nangona utyando , i- chemotherapy , kunye neyeza zonyango zihlala zibalulekile ukhetho lwezokonyango zomhlaza wekolon, unyango olusisigxina se-antioclonal luyafumaneka kakhulu. I-antioclonal antibodies treatments for the control of the cancer of colon yiBevacizumab (Avastin), Cetuximab (Erbitux), ne-Panitumumab (Vectibix).
Ziziphi i-Antioclonal Antibodies?
Ama-antibodies ama-Monoclonal ayenamaprotheni akwenziwa kwibhubhoratri. Ezi proteins zenzelwe ukudibanisa kwiindawo eziphezulu kumaseli omhlaza kwaye ziphazamise ukukhula kwazo kwaye zisasazeke. Amanqindi e-Monoclonal afana namagciwane omzimba wakho ngokuvelisa ngokuvelisa kwiibhaktheriya okanye kwiintsholongwane, ezinjengobanda okanye umkhuhlane (umkhuhlane).
I-Monoclonal Antibodies Work?
Iiseli emzimbeni wethu, kubandakanywa neeseli zomhlaza, zineendawo kwiindawo ezibizwa ngokuba yi-receptors. Lawa ma-receptors anceda ukulawula indlela iiseli zethu zikhula ngayo, ziyeke ukukhula, okanye zenze nayiphi na into iiseli ngokuqhelekileyo zenza. Ukuba iprotheyini elungileyo ifika kunye kwaye ifake (ibopha) kwi-receptor kwiseli, oku kubangela ukuba iseli iphendule.
Indlela efanelekileyo yokucinga ngamamkeli kunye neeprotheni zabo ezibophayo kukucinga ngekhikhi kunye nentloko. Ikhutshana ayiyi kuvula ngaphandle kwesona sokunene. Ngendlela efanayo, i-receptor ayiyi kubangela iseli ukuba ikhule, idibanise, okanye iphendule ngaphandle kokuba "inqakraza" yesokudla kwi-receptor idibanisa kuqala.
Kwaye kunye neengqamzana zamanqwelana zi "zihluthulelo" ezijoliswe ngokukodwa ukuba zixhomekeke kumamkeli kwiiseli zomhlaza.
Imizekelo yeMonoclonal Antibody Therapies
I-epidermal growth factor receptors (EGFRs) ngumzekelo omnye wee-receptors ezijoliswe kwi-antibodies monoclonal. I-EGFR zikhoyo kwiiseli eziqhelekileyo kunye namaseli omhlaza, kodwa ngeeseli zomhlaza, ezi zifunyenwe zizinto eziqhelekileyo.
Kukho nobuninzi be-EGFR okanye bangonakaliswa okanye batshintshwe (batshintshe) ngendlela ebenza baphendule ngokuphindaphindiweyo kwizibonakaliso zokukhula. Oku kwenza ukuba iiseli zomhlaza zikhule ngokukhawuleza okanye zikhule kwiindawo ezingafanele zikhule.
I-oneuximab (Erbitux) ne-Panitumumab (Vectibix) idibanisa ngokuthe ngqo kwi-EGFR efumaneka kumaseli omhlaza. Xa befakela kwi-EGFRs, banqanda izibonakaliso zokukhula ezivame ukuvelisa umzimba wakho ekufikeleleni kumaseli omhlaza. Oku kunciphisa okanye kumise ukukhula komhlaza.
Ukucinga ngokutshintshi kunye nokuphambili, unokucinga ukuba i-Cetuximab ne-Panitumumab basebenza njengokuba umntu unamathela kwi-lock. Isihluthulelo asikwazi ukungena kwaye umnyango awukwazi ukuvulwa ngenxa yokuba i-receptors yeseli yomhlaza sele "iqhutywe" yi-antibodies ye-monoclonal. Oku kuthetha ukuba iiseli zomhlaza azifumani iimpawu zokukhula ezifunekayo ukuze ziqhubeke zikhula kwaye zisasazeka.
I-Conjugated Antioclonal Antibodies
Ngaphandle kokugqithisa nje umsebenzi weesilini ze-tumor, i-anti-body antibodies ingahlanganiswa neziyobisi ze-chemotherapy okanye i-particle radiac (i-radioimmunotherapy) ukuze bathathe inyathelo lokonyango ngokufanelekileyo kumhlaza kwaye kungekhona kwiiseli eziqhelekileyo. Oku kusetyenziswa ngeendlela ezithile ze-lymphoma kunye nomhlaza wesifuba kunye neziyobisi zingase zifumaneke ukuphatha ezinye iifom zomhlaza.
Ziziphi iimpembelelo ezingeNtsholongwane ye-Antioclonal Antibody?
Kubantu abaninzi, iimiphumo ezibi zonyango lonqwelweyo lwama-antioclonal zinamandla kunokhemotherapy kwaye zifana neendlela zokuziphendulela. Ezinye zeempembelelo eziqhelekileyo zesifo se-antioclonal antibody ziquka:
- Utywala
- Ukukhwabanisa isikhumba okanye imisundu
- Izimpawu ezinjenge-Flu ezinjengomkhuhlane, izibonda, izihlungu zomzimba, ukukhathala kunye nentloko
- Uhudo
- Isihlunu kunye nokuhlanza
- Uxinzelelo lwegazi oluphantsi
Abanye abantu banempembelelo enkulu kwi-antioclonal antibody. Iziphumo ezibi kakhulu ezingabangela ugqirha ukuyeka unyango lwe-antioclonal antibody lubandakanya:
- Igazi eliphantsi kakhulu libala
- Iingxaki zeentliziyo zibandakanya ukubetha kwentliziyo, ukungaphumeleli kwentliziyo, kunye nobungozi bokuhlaselwa kwentliziyo
- Amanqanaba aphantsi e-magnesium, i-potassium, okanye i-calcium egazini lakho, ezinokubangela iingxaki zempilo ezinzulu
- Iimfumba ezinqabileyo zesikhumba ezikhokelela kwizifo
- Iingxaki zokuhlamba
- Ukuphendula ngokukhawuleza ekufakeni ukufakela kubandakanya ukuphefumula okufutshane, ukuvuthwa, ukukhathala, ukuphazamiseka, ukuxakeka, ukutyhafaza, ukubonwa komsindo, isantya, okanye intlungu yesifuba okanye uxinzelelo
Ngethamsanqa, xa kwenzeka ukuphendulwa okukhulu, zidla ngokukhawuleza ukuba zenzeke ngokukhawuleza, xa ufumana iyeza lonyango kwiklinikhi yokunakekelwa ngumhlaza. Oku kuthetha ugqirha wakho kunye nomongikazi uya kukubeka esweni kwaye uya kukwazi ukumisa ukunyuswa xa kudingekile kwaye kukunikezela ngonyango ngokukhawuleza.
Ndingayigcina njani iMonoclonal Antibody Treatment Side Effects?
Izinto ezimbini ezibaluleke kakhulu ongayenza ukulawula iziphumo zecandelo le-antioclonal anti-antibody:
- Thatha onke amayeza akho njengoko kumiselweyo, kuba kulula ukukhusela iziphumo zecala kunokuziphatha xa zenzeka.
- Gcina imizila yokunxibelelana evulekileyo neqela lakho lezonyango. Yintoni esebenzayo ekulawuleni imiphumo emibi kumntu omnye akanakukusebenzela. Thetha ugqirha okanye umongikazi malunga neendlela zokunceda ufumane unyango ngeempembelelo ezincinci.
Ungamkeli ukuba uvakalelo olubi luyinxalenye yemvelo yonyango lomhlaza. Kukho indlela yokuba iqela lakho lonyango likwazi ukulawula kangcono imiphumo yakho yecala. Ukuba ufuna uncedo, cela. Kwaye rhoqo, ukuba unemibuzo malunga nemiphumo emibi, biza iqela lakho lezonyango ngokukhawuleza.
Imithombo
I-Fakih M. Anti-EGFR i-anti-Ebola i-monoclonal antibodies in cancer-coloredal cancer: ixesha leendlela ezizimeleyo? Ingcali yoTyhulwa kweAnticancer Ther 2008 8: 1471-80.
Medline Plus. Bevacizumab Injection.
https://medlineplus.gov/druginfo/meds/a607001.html
Medline Plus. Inuximab Injection.
https://medlineplus.gov/druginfo/meds/a607041.html
Medline Plus. I-Panitumumab Injection.
https://medlineplus.gov/druginfo/meds/a607066.html
Patel DK. Ukusetyenziswa kwintsholongwane ye-anti-epidermal growth factor receptor monoclonal antibodies kwisifo somdlavuza we-metastatic. I-Pharmacotherapy 2008 28: 31S-41S.
Ramos FJ, Macarulla T, Capdevila J, Elez E, Tabernero J. Ukuqonda indima ebalulekileyo ye-K-ras ye-epidermal ukukhula kwezinto ezijoliswe ku-epidermal kwi-tractor-cancer. Iklinikhi yeColorectal Cancer 2008 7: S52-S57.
I-American Cancer Society. Antioclonal Antibodies. Kufumaneka: Umhla wama-4, 2015.
http://www.cancer.org/treatment/treatmentsandsideeffects/treatmenttypes/immunotherapy/immunotherapy-monoclonal-antibodies