I-Methotrexate ifakwe ngokuqhelekileyo ukunyanga i- rheumatoid arthritis kunye nezinye izimo ze-rheumatic. I-Methotrexate ihlelwa njengesichengiso se-anti-rheumatic drug (DMARD). Isilwanyana sinciphisa intlungu kunye nokuvuvukala okuhambisana ne-rheumatoid arthritis, kunciphisa ukuqhubela phambili kwesi sifo, kwaye kunceda ukukhusela umonakalo odibeneyo. Xa ucinga ngempumelelo nokukhuseleko, i-methotrexate injection engcono kune-methotrexate yomlomo?
Ukufumaneka
I-methotrexate yomlomo iyatholakala kwiiphilisi ezi-2.5 mg. I-dose yokuqala yesiqhelo kubantu abadala abane-arthritis ye-rheumatoid i-7.5 ukuya ku-10 mg (i-3 ukuya kwi-4 iipilisi) ithathwa kunye kanye ngeveki. Ukuba kuyimfuneko, umthamo ungancinwa ngokuthe ngcembe ube ngu-20 ukuya ku-25 mg ngeveki. Ugqirha wakho uya kugqiba umthamo ochanekileyo kuwe.
Injini ye-Methotrexate inikwe phantsi kwesikhumba (ngaphantsi). Iza njenge-25 mg nge-1 milliliter okanye i-cubic cm. Kwakhona, ugqirha wakho uya kubala umthamo onokuwusebenzisa. Kubantwana abane-rhumatoid arthritis yabantwana, i-dose isekelwe ubunzima bomntwana.
Yiyiphi ifom ye-Methotrexate ekhethwa?
Injini ye-Methotrexate ithathwa njengento elula kakhulu kwizigulane ezininzi xa kuthelekiswa nemettretreate yomlomo. Ukuthenga ii-syringes nokuzibamba ngenaliti nganye ngeveki kunokuba yintsholongwane. Abanye abantu basenaliti-phobic. Ngoko, kutheni ubandezeleke xa unokuphepha iipilisi ezimbalwa?
Kuthekani ukuba kuthe kwahluka umahluko phakathi kwe-methotrexate injection kunye ne-methotrexate yomlomo ngokubhekiselele kwimpumelelo kunye nomngcipheko weempembelelo ezibi?
Ngokweziphumo zoluvavanyo lwekliniki yokuqala ukwenzela ukuba uphando ngokuchanekileyo ulawulo lwe-methotrexate kwizigulane ezine-arthritis esebenzayo, epapashwe ngoJanuwari 2008 yeArthritis & Rheumatism, i-methotrexate injection (ekwabizwa ngokuba yi-methotrexate engaphantsi) iyasebenza ngakumbi kunomlomo Ukulawulwa kwe-methotrexate kwisilinganiselo esifanayo, kungabikho ukwanda kwimiba emibi.
Kwakukho abathathi-nxaxheba abangama-384 kwisifundo seveki ezingama-24 abaye banikwe i-methotrexate injection okanye i-methotrexate yomlomo. Abafundi abathathi-nxaxheba, bathi banomsebenzi ophezulu wesifo ekuqaleni kweso sifundo, bafumana injini ye-methotrexate ye-15 mg yevekitrexate kunye ne-placebo yomlomo okanye i-15 mg yomlomo nge-weekly methotrexate kunye ne-placebo injection.
Kusuka kwidatha yokufunda, abaphandi baphetha ngokuthi i-methotrexate injection, esebenzisa umlinganiselo we-15 mg / weveki ubuncinane ubuncinane ubuncinane beeveki ezingama-24 (kubandakanywa ukunyuka kwenyango), uphezulu ukuqaliswa kwe-methotrexate ngomzila womlomo. Kwiiveki ezingama-24, ipesenteji yezigulane ezineempendulo ze- ACR20 ziphezulu kakhulu kwiqela elitholayo i-methotrexate injection (i-78%) kuneqela elifumana i-methotrexate yomlomo (70%).
I-Methotrexate i-Slow-Acting
Ngokusetyenziswa kwe methotrexate, ukuphucula iimpawu ze-rheumatoid arthritis okanye umsebenzi wesifo ngokuqhelekileyo kufunyanwe kwiiveki ezi-3 ukuya kwezi-6. Ingathatha iiveki ezili-12 zonyango kunye ne-methotrexate ukufumana inzuzo epheleleyo.
Imiphumela
Uninzi lwezigulane ze-rheumatoid arthritis azibi naziphi na iziphumo ezichaphazelekayo ngelixa zithatha methotrexate. Ezinye izigulane zifumana iimpembelelo ezincinci eziphucula ngaphezulu kwexesha.
Impembelelo yecala eliqhelekileyo le-methotrexate isisonguluko.
Ezinye iziphumo ezichaphazelekayo zingabandakanya iimvavanyo zentsholongwane engavumelekanga, izilonda zomlomo , ukukhawuleza, isifo sohudo, ukulahleka kweenwele , ukuzwela kwelanga , kunye nokungaqhelekanga kwiibalo zegazi. Kukho iingxaki zeengxaki zemiphunga.
Imithombo:
I-Methotrexate (iRheumatrex, iTrxall, i-Otrexup, iRasuvo). Ikholeji yaseMerika yaseRheumatology. UMichael Cannon, MD. Matshi 2015.
Ukuthelekiswa kokusebenza kweeklinikhi kunye nokukhuselwa kokulawulwa komlomo kunye nokulawulwa komlomo we-methotrexate kwizigulane ezine-arthritis esebenzayo. Braun et al. IArthritis & Rheumatism Umqulu 58, I-Issue 1, iphepha 73-81. Disemba 28, 2007.