I-Rheumatologists ingahluka kwi-folic acid supplementation
Kuqhelekileyo ukuba oogqirha banqume i-folic acid kwizigulane zabo ze-rheumatoid arthritis eziphathwe nge-methotrexate. I-acid ye-folic iphelelwe yimettretreate, ngoko kufuneka izaliswe ngokuxhaswa. I-acid ye-folic iyadingeka ukukhusela isalathisi segazi ebomvu kunye nokuphelelwa kwegazi. Kuye kwabonwa ukunciphisa isisulu sokususa isicupho esivela kwi-methotrexate.
I-Methotrexate yinto echazwe ngokuqhelekileyo ye- DMARD (isifo sokuguqula iziyobisi ezichasene ne-rheumatic) kwi- rheumatoid arthritis kunye nezinye izimo ze-rheumatic. I-Methotrexate ifumaneka kwimimiselo yomlomo kunye neyiyo . Ngandlela-thile, i-methotrexate idla ngokuqhutywa kanye ngeveki (ngosuku olufanayo ngeveki).
Zithini Iinkonzo Zezokwelapha Zithetha NgeAlilic Acid
Kukho ukutshintsha nokuba ngaba oogqirha balela i-dose yemihla ngemihla ye-1 milligram ye-aclic folic okanye i-dose enkulu ngeliveki. I-dose enkulu idlalwa ngemini emva komthamo we-methotrexate. Ngamanye amaxesha oogqirha bacebisa izigulane zabo ukuba badumise umthamo wemihla ngemihla ye-dohotrexate dose.
I-National Rheumatoid Arthritis Society e-UK, "I-Methotrexate idlulela umzimba we-aclic acid kunye negalelo lemiphumo emibi ingancitshiswa ngokuthatha izongezelelo ze-folic acid. Oku kungathathwa njenge-5 ukuya kwi-10gramgram nganye ngeveki. ukuphumelela kwe-methotrexate kwaye ezininzi i-rheumatologists zincoma ukuthatha i-folic acid enye okanye iintsuku ezimbini emva kwe-methotrexate, kwaye ngokukodwa ingayithathi ngosuku olufanayo ne-methotrexate. "
Iishedyuli ezahlukeneyo zonyango nge folic acid zingakhokelela kwimibandela malunga nokuba yintoni efanelekileyo. I-Rheumatologist uScott Zashin, uprofesa oncedisayo wezonyango kwiYunivesithi yaseTexas Southwestern Medical School uthi, "Ndiziphethe izigulane zam imihla ngemihla, kubandakanywa nosuku lwe-methotrexate. Ndicinga ukuba kulungile okanye kubandakanyeka ngosuku.
Akuzange ifundwe, kodwa akunakwenzeka ukuba nayiphi na inkqubo inobungozi. "
Izigqibo ezivela kwi-Cochrane Review
Kwingxelo malunga nokuhlaziywa kwe-Cochrane epapashwe ngoJulayi 2013, ebonise ubungqina obuxhasa ukusetyenziswa kwe-aclic acid ukunciphisa imiphumo emibi ehambelana ne-methotrexate, kuboniswe ukuba i-folic acid isebenzayo-oogqirha abathile banikezela i-folic acid ukuba isetyenziswe rhoqo izigulane ezithatha i-methotrexate, ngelixa abanye oogqirha banika kuphela izigulane ezineempembelelo ezivela kwi-methotrexate. Kanti abanye abayikuyibeka yonke into ngenxa yokuba bakholelwa i-acid ye-folic kunciphisa ukuphumelela kwe-methotrexate.
Ukuhlaziywa, ngokusekelwe kwiziphumo ezivela kwizilingo ezithandathu zonyango, zixhaswa ukusebenzisa i-folic acid ephantsi kwezilwanyana ze-rheumatoid arthritis eziphathwe nge-methotrexate. Ukuncedisa i-folic acid kunciphisa ubunetyhefu besisu nokunyuka kwe- enzyme yesibindi . Umhleli uphakamise ukuba i-folic acid 1 milligram nsuku zonke iyona isetyenziswa ngokuqhelekileyo kwongezelelo lwezigulane eziphathiswe nge-methotrexate.
Ukuhlaziywa kunye nokuhlelwa okulandelelanayo kwaphakamisa imibuzo nokuba ngaba izigulane kufuneka zithathe i-folic acid bonke ubomi babo, nokuba ngaba amayeza aphezulu ayanceda okanye anokuphazamisa i-methotrexate.
Kwagqitywa ukuba ubudlelwane be-dose-effect buya kufuna iimfuno ezingakumbi.
Ngaphantsi
Kukho iinkqubo ezahlukeneyo ezamkelekileyo zokuthabatha i-folic acid xa uphathwa nge-methotrexate, kunye nezifundo ezongezelelweyo zingabonisa ukuba enye ikhethayo. Xoxa ngokugqithiseleyo nogqirha wakho ukuqonda ukuba kutheni ukhetha enye.
Imithombo:
> Butler R. Methotrexate kwi-Rheumatoid Arthritis. National Rheumatoid Arthritis Society. https://www.nras.org.uk/methotrexate-in-rheumatoid-arthritis.
> Singh JA. Izilwanyana ze-folic acid ezongezelelekileyo izigulane ze-rheumatoid ezithatha i-methotrexate: ezilungileyo ziba ngcono (uhleli). I-Cochrane Database yeeNkcazo eziPhezulu 2013; 7: ED000063. dx.doi.org/10.1002/14651858.ED000063
> Shea B, Swinden MV, Tanjong Ghogomu E, Ortiz Z, Katchamart W, Rader T, et al. I-acid ye-folic kunye ne-folinic acid ukwenzela ukunciphisa iziphumo ezichaphazelekayo kwizigulane ezifumana i-methotrexate yesifo se-rheumatoid arthritis. I-Cochrane Database yeeNkcazo eziPhezulu 2013; 5: CD000951. dx.doi.org/10.1002/14651858.CD000951.pub2