Iingxaki ezintsha zophando iingxelo ze-methotrexate ingozi
I-Methotrexate iyisistim sokukhusela isigxina sokuxilonga umzimba esetyenziselwa ukunyanga iintlobo ezithile zomhlaza kunye nenani leengxaki zokuzimela , kuquka i-psoriasis enamandla kunye ne- rheumatoid arthritis (RA) .
Okumangalisayo kukuba, uphando oluninzi luye lwaphakamisa ukuba i-methotrexate inokunyusa ingozi yomhlaza kubantu abane-RA, kuquka i-melanoma, i-leukemia, i-myeloma, umhlaza wamaphaphu kunye ne-lymphoma.
Kwiminyaka eyi-10 ukususela kokuqala kwezo zifundo, kuye kwaba neengxoxo eziqhubekayo malunga nokuba umngcipheko wangempela unokuba njani. Ngaba i-methotrexate ikhuselekile ukusebenzisa, okanye ngaba kukho izinto ezinokubeka abanye abantu engozini enkulu kunabanye?
Oko Uphando Lwasekuseni lusitshele
Ngo-2008, uphando lwase-Australia lwaluhlolisisa iimbali zonyango zabafazi abangama-309 kunye namadoda angama-150 anama-RA abasebenzisa i-methotrexate ngaphambi ko-1986 kunye nokuthelekisa umlinganiselo womhlaza kuloo qela kubantu bonke.
Ngokomphando, abantu abane-RA abaye bavelelwa kwi-methotrexate babenomngcipheko omkhulu wama-50 wokuphucula umdlavuza kwanoma yiluphi uhlobo. Ngaphezu koko, banokunyuka kwamahlanu kwingozi yokungabikho kweHodgkin lymphoma (NHL) kwakunye nokunyuka kathathu komdlavuza wamaphaphu kunye nobungozi be- melanoma .
Kulabantu abangama-459 ababandakanyiweyo kwisifundo, iziganeko ezingamalungu angama-87 zachongwa.
Nangona uphando lwaluxhasa ukuphanda kwangaphambili emngciphekweni we-NHL nomdlavuza wamaphaphu kubantu abasebenza kwi-methotrexate-basedrapy, abaninzi abantu kwizenzululwazi bahlala bengacacanga ukuba ingaba i-methotrexate yayiyi-culprit okanye isifo ngokwayo.
Oku kwakuyinyaniso ngokukodwa kwi-melanoma ukususela kwindlela uyilo oluthile aluzange luvumele ukuba kufakwe izinto ezinobungozi ezifana nobudala okanye ukukhanya kwelanga.
Oko Uphando Lwanje lusitshela
Ngo-2017, izazinzulu kwiYunivesithi yaseGenhenburg eSweden zaqhuba uphando oluthile lokujonga ngokusemngciphekweni we-melanoma kwizigulane eziphathwe nge-methotrexate ezine-RA.
Ukusebenzisa iinkcukacha ezivela kwiBhodi leZwelonke lezeMpilo kunye neNtlalontle, abaphandi bahlalutya iifayile zecala nawuphi na umntu oneminyaka engaphezu kwe-18 ubudala oye wahanjiswa le nkunkuma ukususela ngo-2005 ukuya ku-2014.
Ngokutsho kophando olushicilelwe, abantu abane-RA abaye baphathwa nge-methotrexate kuphela babenomngcipheko ophezulu we-melanoma kunabantu bonke. Ngaphezu koko, ubuninzi bala mava babandakanya abesetyhini abaye baqalisa unyango emva kweminyaka engama-70. Ngaloo ndlela, iminyaka ingadlala indima enkulu kunokuba i-melanomas ibonakala kubantu abangaphezu kwama-65.
Abanye abaphandi, okwangoku, baye baqala ukuphanda umbutho phakathi kwe-RA kunye nomhlaza nangakhathaliseki i-methotrexate. Olunye uphando olunjalo olwenziwa yiYunivesithi yaseMary School School of Medicine luhlolisise idatha ukusuka kwizifundo ezisixhenxe zekhwalithi eziphezulu ezipapashwe phakathi kuka-2008 no-2014.
Iimpapasho ezilisithoba zidibanisa i-criteria yokungeniswa. Ezi sixhenxe zaphanda ingozi yomdlavuza kubantu abane-RA; ezisibhozo zijonge i-lymphoma, i-melanoma, imiphunga, i-colorectal, kunye nomhlaza wesifuba; ezisixhenxe zijoliswe kumdlavuza wesibeletho; kwaye uphando olwenziwe uphando lomhlaza wesibeleko.
Emva kokugqitywa kokuhlaziywa, abaphandi babika ukuba ingozi yomhlaza yayingaphezulu kweepesenti ezili-10 kunabantu bonke.
Ngaphezu koko, umngcipheko wesifo sombele, isisu, umbala, kunye nomhlaza wesifo seprotate wawuncinci ngokuthelekiswa.
Okufanayo akuzange kubambelele kwezinye i-cancer. Phakathi kweziphumo:
- Isantya se-lymphoma sasiphakamileyo kakhulu, ingakumbi isifo seHodgkin esine-12 kwenyuka kwengozi.
- Umdlavuza womlenze ngokubanzi ubonisa ukunyuka kabini.
- I-Melanoma yayinexabiso elingaphantsi kweepesenti ezingama-25
Akumangalisi ukuba ezi ziinkcukacha ze-Cancer zigqatshelwe ngokucacileyo kwisifundo se-Australia.
Oku akuchazi ukuba i-methotrexate ayidlala nxalenye kwingozi yomhlaza. Kusitshela nje ukuba unonophelo olongezelelweyo kufuneka lithathwe ukuqinisekisa ukuhlolwa kwesifo somhlaza kubantu abane-RA nokuba i-methotrexate imiselwe okanye ayikho.
> Imithombo:
> Buchbinder, R .; Barber, M .; Heuzenroeder, uL. et al. "Isiganeko se-melanoma kunye nezinye izigulane phakathi kwezigulane ze-rheumatoid arthritis ziphathwa nge-methotrexate." Arthritis Rheum . 2008; 59 (6): 794-9. INGXELO: 10.1002 / ubugcisa.23716.
> Polesie, S .; Gillstedt, M .; UNyana, H. et al. "I-Methotrexate unyango kunye nomngcipheko we-melanoma ebulalayo. Brit J Derma. 2017; 176 (6); 1492-1499. INGXELO: 10.1111 / bjd.15170.
> Simon, T .; Thompson, A .; Gandhi, K. et al. "Isiganeko sokusweleka kwezigulane zabantu abadala abanesifo se-rheumatoid arthritis: a .meta-analysis." . Arthritis Res Ther. 2015; 17 (1): 212. INGXELO: 10.1186 / s13075-015-0728-9.