I-Otrexup I-Autoinjector eyi-Single-Dose Autoinjector
I-Otrexup ( methotrexate ) yi-autoinjector ene-dose-single-dose ene-prescription drug methotrexate. I-Otrexup yavunywa kuqala yi-US FDA ngo-Oktobha 11, 2013. I-Otrexup, eyenziwe ngu-Anatares Pharma, Inc. yindlela ehlukile kumlomo we-methotrexate, i-vial-and-syringe injectable methotrexate, okanye enye i- auto -jector ye -single-dose, iRasuvo .
Imiqondiso ye-Otrexup
I-Otrexup, i-analog ye-analog metabolic inhibitor, yayivunywe yi-FDA yolawulo lwabantu abane- arthritis enobuchopho , esebenzayo kunye ne- polyarticular ye-idiopathic arthritis abangenayo impendulo enganeleyo kwiyeza lokuqala. I-Otrexup yavunywa kwakhona ukulawulwa kweempawu ezinxulumene nokukhawuleza, ukukhubaza i-psoriasis kubantu abadala abaye bafumana impendulo engonelanga kwamanye unyango. I-Otrexup ayivunywanga ukunyangwa kwezifo ze-neoplastic.
Ulawulo lwe-Otrexup
Ukuqala amanani e-methotrexate yi-7.5 mg kanye ngeveki kubantu abane-arthritis ye-rheumatoid, i-10 mg / m2 kanye ngeveki kwiigulane ezine-aryarritis ye-polyarticular ye-idiopathic arthritis, kunye ne-10 ukuya kuma-25 mg kanye ngeveki ye-psoriasis. I-Otrexup ilawulwa nje ngejoyiki, ngezantsi. Inokuthi ifakwe kwisitya okanye isisu ngesalathisi.
I-Otrexup ifumaneka kwiidayari eziphakathi kwe-10 ukuya ku-25 mg kwi-5 mg increments.
Olunye uhlobo lwe-methotrexate, ngaphandle kwe-Otrexup, kufuneka lisetyenziswe kwizigulane ezifuna umlomo, intramuscular, intravenous, intra-arterial, okanye intrathecal dosing, amanani angaphantsi kwama-10 mg ngeveki, amanani angaphezu kwama-25 mg ngeveki, ii-dose , okanye utshintsho lwezilwanyana ezingaphantsi kwama-5 mg.
Ukungqinelana
Otrexup akufanele isetyenziswe ngabasetyhini abakhulelweyo, oomama abanamano, okanye abo abaneesifo sesibindi okanye utywala. Kwakhona, i-Otrexup kufuneka igwenywe ngabantu abane-immunodeficiency syndromes, iingxaki zegazi ezandulela ngaphambili, okanye i-hypersensitivity eyaziwa kwi-methotrexate.
Izimpembelelo eziqhelekileyo
I-Otrexup idibene neempembelelo eziqhelekileyo ezibandakanyekayo, kubandakanya: isicupunu, intlungu yesisu, i-dyspepsia, ukuvuvukala komlomo, izilonda zomlomo, ukugqithisa, i-nasopharyngitis, isifo sohudo, ukusebenza kwesibindi, ukuhlanza, intloko, i-bronchitis, inani leplatelet eliphantsi, inani eliphantsi legazi elimhlophe iiseli, ukunqongophala kwazo zonke iintlobo zeeseli zegazi, ukungcola, iifenensitivity, ne-alopecia.
Ukuba ufumana isiganeko esibi okanye ukuphendula okungalunganga, unokuyibika kwi-FDA kwi-http: //www.fda.gov/medwatch/ okanye ngokubiza u-1-800-FDA-1088. Unokuqhagamshelana nomenzi we-Otrexup kwi-http: //www.otrexup.com okanye ngokubiza u-1-855-Otrexup (1-855-687-3987).
Ukusebenzisana kweziyobisi
Ukuthatha i- aspirin , i- NSAID , okanye i- corticosteroids kunye ne-Otrexup inokunyusa amazinga e-serum methotrexate obangela ukwanda kwetyhefu. Ukuthatha i- proton pump inhibitors ngenkathi usebenzisa i-Otrexup nayo inokunyusa nokunyusa amazinga e-serum methotrexate, okwandisa umngcipheko wezobisi.
Qiniseka ukuba ugqirha unalo uludwe lwangoku zonke iyeza kunye nezibonelelo ezithathayo. Kwakhona ingcinga efanelekileyo yokusebenzisa ikhemithi enye, ukuba kunokwenzeka, yonke imithi yakho yonyango. Kulula ukulandelela ukusebenzisana kwezidakamizwa ukuba ngaba zonke iziyobisi zakho zikho kwinkqubo yekhompyutheni oyikhethayo.
Izilumkiso kunye nokuqapha
Kukho isilumkiso esimnyama esikhankanywe kunye ne-Otrexup esithetha ukuba iimpendulo ezinobuthi nokufa ziye zabikwa ngokusetyenziswa kwe-methotrexate. Izigulisi ezisebenzisa iziyobisi kufuneka zihlolwe ngethambo lomongo, isibindi, umphunga, isikhumba, kunye nesifo sobutywala. I-Methotrexate nayo ibikwa ukuba ibangele ukufa komntwana okanye ukuzalwa okungavumelekanga okuyiyo isizathu esichasene nokukhulelwa.
Ukunyanzeliswa komnkantso wethambo ongalindelekanga, i-anemia ye-anemia, kunye nesisu sokunyangwa kwamathumbu kuye kwabikwa kwiigulane ezithatha ii-NSAID ngelixa zisebenzisa i-methotrexate. Inetyhefu yesibindi, i-fibrosis, kunye ne-cirrhosis inokwenzeka emva kokusetyenziswa kwexesha elide le-methotrexate. I-pneumonitis ye-interstiti iyakwenzeka naliphi na ixesha kwaye kunye ne-low dosage ye methotrexate. Isifo sohudo, i-ulcerative stomatitis, i-enteritis enobuhlungu, kunye ne-intestinal perforation. Ubunzima, obunokubulala, ukuguquka kwesikhumba kunokwenzeka. Kungenzeka ukuba izifo ezichaphazelekayo ezichaphazelekayo zingahlakulela.
I-non-Hodgkins lymphoma kunye nezinye izihlamba ziye zaxelwa kwizigulane eziphathwe nge-dohotrexate ephantsi. Kufuneka kuqatshelwe ukuba kwiimeko apho i-lymphoma enokuphuhliswa ngexesha lonyango kunye ne-methotrexate, ukuyeka i-methotrexate kwanele ukwenzela ukunyuswa kwe-lymphoma.
I-Methotrexate ibikwa ukuba ibangele ukungabi nabantwana kwezinye izigulane, izibalo ezingaphantsi kweentsuku kunye nokungasebenzi komzimba. Oku kunokuba yingxaki ngelixa i-methotrexate isetyenzisiweyo kunye nexesha elide emva kokuba lime.
ILizwi
Abantu basebenzisa i-Otrexup kufuneka babe neemvavanyo zegazi ngexesha eliquka ukubala okupheleleyo kwegazi, ii-enzyme zesibindi, kunye neemvavanyo zesebenzi zeentso. Ukuba iimpompo zikhankanywa, iimvavanyo ze-x-ray kunye ne-pulmonary function ziyimfuneko.
Abantu basebenzisa i-Otrexup kufuneka babe nolwazi malunga nemiphumo emibi, ukuze bakwazi ukuqonda nokunika ingxelo ngokukhawuleza xa zenzeka. Kuyavunywa, uluhlu lweziganeko ezinobungozi obuyingozi, kodwa khumbula, abaninzi abantu basebenzisa methotrexate ngaphandle kokufumana nayiphi na ingxaki. Ukwazisa kunye nokubeka iliso kubalulekile.
Imithombo:
Otrexup. Ukwazisa ngokugcwele . Ukuhlaziywa 3/2016.
I-Otrexup Approval History. Drugs.com.