Izinzuzo zezeMpilo, iziSebenzi, nokunye
I-Glucosamine yinkomfa efunyanwa ngokwemvelo emzimbeni, eyenziwe kwi-glucose kunye ne-amino acid glutamine. I-Glucosamine iyadingeka ukuvelisa i-glycosaminoglycan, i-molecule esetyenziselwa ukubunjwa kunye nokulungiswa kwe-cartilage nezinye izicubu zomzimba.
I-Glucosamine Usetyenziso lwe-Osteoarthritis
Ekubeni ukuveliswa kwe-glucosamine kunciphisa iminyaka yobudala, abanye abantu basebenzisa i-glucosamine supplements ukuze balwe neemeko zempilo ezinxulumene nokuguga, njenge- osteoarthritis .
Ukuthatha i-glucosamine njengesongezelelo sesondlo kucingelwa ukuba kugcinwe i-osteoarthritis ukujonga ngokubuyisela i-glucosamine yomzimba kunye nokulungisa i-cartilage ewonakele.
Glucosamine kunye neCondroitin okanye i-MSM
I-Glucosamine ivame ukuhlanganiswa ne-chondroitin sulfate, i-molecule ngokuqhelekileyo ikhona kwi-cartilage. I-Chondroitin inika i-cartilage elasticity kwaye ikholelwa ukuba inokuthintela ukutshabalalisa i-cartilage ngama-enzyme.
Kwezinye iimeko, i-glucosamine idibene kunye ne-methylsulfonylmethane (okanye i- MSM ) kwizondlo ezondlo.
Ukusetyenziswa kweGlucosamine
Ngenye iyeza, abacebisi bathi i-glucosamine inokukunceda ngeengxaki zempilo ezilandelayo:
- Sikashukela
- Cholesterol ephezulu
- Ukuvutha
- Isifo sesisu sokukhupha (njengesifo sesilonda esiswini )
- Osteoarthritis
- Irheumatoid arthritis
- I-Temporomandibular-disorder disorder (eyaziwa nangokuthi "TMD" okanye "TMJ")
I-Science Behind Glucosamine
Uphando lubonisa ukuba i-glucosamine inokubonelela ngezibonelelo ezithile zezempilo.
Nanku ukukhangela kwiziphumo zophando:
Osteoarthritis
I-Glucosamine inokuba yinzuzo ekhatyweni kwe-osteoarthritis (ngokukodwa i-osteoarthritis yegolo), ngokutsho kweeNational Institutes of Health (NIH).
Inyaniso, ingxelo ka-2005 eyapapashwa kwiConnet Database yaseCchrane yeeNkqubo eziPhezulu ziphelile ukuba ezinye izilungiselelo ze-glucosamine zinokunciphisa intlungu kunye nokuphucula ukusebenza kubantu abane-osteoarthritis.
Ingxelo, abaphandi bahlalutya izifundo ezingama-20 (kunye nezigulane ezingama-2,570) ekusebenziseni i-glucosamine ekwenzeni unyango lwe-osteoarthritis.
Kukho ubungqina bokuba i-glucosamine inganciphisa ukuqhubela phambili kwe-osteoarthritis. Ngo-2002 uphando olusuka kwi-Archives of Internal Medicine, umzekelo, abantu abangama-202 abane-osteoarthritis abanomzimba omncinci ukuya kumodareyitha bathatha i-1,500 mg ye-glucosamine okanye i-placebo yimihla emithathu.
Ekupheleni kolu cwaningo, abaphandi bafumene ukuba i-glucosamine yanciphisa ukunyuka kwe-knee osteoarthritis kunye nokunciphisa intlungu nokuqina. Ngaphezu koko, i-X-ray ayibonakali ukuba utshintsho olubanzi okanye ukuxinwa kweendawo ezidibeneyo emadolweni (uphawu lokungonakali) phakathi kwamalungu eqela le-glucosamine. Ngokwahlukileyo, izithuba ezidibeneyo kubathathi-nxaxheba be-placebo zincinci ngaphezu kweminyaka emithathu.
Enye yezona zifundo ezinkulu kwi-glucosamine ye-osteoarthritis yayisifundo seenyanga ezi-6 esixhaswe yiZizwe zeSizwe zezeMpilo kwaye sapapashwa kwi-New England Journal of Medicine ngo-2006. Sibizwa ngokuba yi-GAIT, uvavanyo olufanisa ukuphumelela kwe-glucosamine, i-chondroitin sulfate, inhlanganisela ye-glucosamine kunye ne-chondroitin sulfate, i-celecoxib, okanye indawo ye-placebo kubantu abane-knee-osteoarthritis.
I-Glucosamine okanye i-chondroitin yodwa okanye idibeneyo ayinciphisi intlungu kwiqela lonke, nangona abantu ekufundeni ngeentlungu ezidityanisiweyo zamadolo babekwazi ukuphendula kwi-glucosamine.
Enye impendulo enkulu ye-GAIT Trial yayikuthi i-glucosamine hydrochloride yayisetyenziselwa i-glucosamine sulphate (ifom ye-glucosamine).
Ingxelo ka-2007 eyapapashwa kwi-Arthritis neRheumatism, uphando bahlalutya uphando lwangaphambili kwi-glucosamine (kuquka i-GAIT Trial) kwaye baphetha ngokuthi i-glucosamine hydrochloride ayizange isebenze. Uhlalutyo lufumanise ukuba uphando lwe-glucosamine sulfate lwaluhluke kakhulu kunye kwaye aluzange lufakwe kakuhle njengoko lufanelekile, ngoko bebengakwazi ukufikelela kwisigqibo. Kufuneka uphando olungakumbi.
I-Temporomandibular Joint Osteoarthritis
I-Glucosamine isenokusebenza ngokufanelekileyo kwi-osteoarthritis, i-temporomandibular ehlangene ne-osteoarthritis, ngokwe-NIH. Ngophando luka-2001 oluvela kwi-Journal of Rheumatology, abaphandi bafumanisa ukuba i-glucosamine yanciphisa intlungu phakathi kweqela labantu abadala abaneli meko.
Ukufunda, izigulane ezingama-45 zathatha i-glucosamine okanye ibuprofen iintsuku ezingama-90. Kwabantu abangama-39 abagqibile ukufundisisa, amalungu angama-15 eqela le-glucosamine kunye namalungu ayi-11 eqela le-ibuprofen abonise ukuphucuka okukhulu.
Ubunzima Bokubuya
I-Glucosamine ingenakunceda abantu abaneentlungu ezingapheliyo zentlungu kunye ne-ostoarthritis ye-lumbar ephazamisayo, ngokutsho kwe-2010 yophando kwi-Journal ye-American Medical Association.
Kwiinyanga ezintandathu, izigulane ezingama-250 ezizimeko zombini zithathe i-glucosamine supplement or placebo. Iziphumo zokufunda zibonise ukuba i-glucosamine ayizange iyanciphise intlungu ephantsi okanye ukukhubazeka okunxulumene nentlungu.
Glaucoma
Ubungqina obunqamlekileyo bubonisa ukuba i-glucosamine ingaba unyango lwe- glaucoma , ngokwemibiko ye-2001 evela kwi-Alternative Medicine Review. Nangona kunjalo, ngenxa yokungabikho kokuhlolwa kovavanyo lweklinikhi ye-glucosamine njengendlela yokwelashwa kwe-glaucoma, kungekudala ukukhuthaza i-glucosamine njengonyango lwe-glaucoma.
Kuphi Ukufumana iGlucosamine
I-Glucosamine ifumaneka njengesongezelelo sezondlo kwiindawo zokutya ezempilo kunye nezitolo ezininzi zezilwanyana. I-Glucosamine iphinda isetyenziswe kwezinye iziphuzo zezemidlalo nakwizonyiso.
I-Glucosamine isongezelelo yenziwe kwi-laboratory evela kwi-chitin, into efumaneka kwiiblokhwe ze-shrimp, crab, lobster kunye nezinye izidalwa zolwandle.
Imijelo
Uninzi lwezifundo ezibandakanya abantu zifumene ukuba i-short-term use of glucosamine iyakunyamezeleka. Funda malunga nemiphumo emibi ye-glucosamine .
Izibonelelo, ngokubanzi, azange zihlolwe ukhuseleko kwaye zigcine ingqalelo ukuba ukhuseleko lwezongezelelo kwabasetyhini abakhulelweyo, oomama abanamancela, abantwana kunye nalabo abanezifo zonyango okanye abathabatha imishanguzo ayenzanga.
Unokufumana amathiphu okhuseleko ekusebenziseni izongezo apha , kodwa ukuba ucinga ngokusetyenziswa kwe-glucosamine, thetha nomboneleli wakho oyintloko.
Ukusebenzisa iGlucosamine kwiMpilo
I-Glucosamine inokuba yinzuzo ethile kubantu abane-osteoarthritis. Kubalulekile ukuba uqaphele ukuba ababoneleli benonophelo lwempilo bavame ukuphakamisa iilingo ezintathu zenyanga ye-glucosamine kwaye bayeke ukuba akukho phuculo emva kweenyanga ezintathu.
Ukuba ucinga ngokusetyenziswa kwe-glucosamine kunyango nayiphi na imeko, xela ugqirha ngaphambi kokuba uqalise i-regimen yokuncedisa.
> Imithombo:
> Clegg DO, Reda DJ, Harris CL, Klein MA, O'Dell JR, Hooper MM, Bradley JD, Bingham CO 3, Weisman MH, Jackson CG, Lane NE, Cush JJ, Moreland LW, Schumacher HR Jr, Oddis CV, I-Wolfe F, iMolitor JA, i-Yocum DE, i-Schnitzer TJ, i-Furst DE, i-Sawitzke AD, i-Shi H, i-Brandt KD, i-Moskowitz RW, i-Williams HJ. I-Glucosamine, iChondroitin Sulfate, kunye neBibini kwi-Combination ye-Painful Knee Osteoarthritis. N Engl J Med. (2006) 354.8: 795-808.
> INtloko KA. "Ukwelapha ngokwemvelo yeengxaki ze-Ocular, Icandelo lesiBili: I-Cataracts kunye ne-Glaucoma." I-Altern Med Rev. 2001 Apr; 6 (2): 141-66.
> AmaZiko eNational Health. "I-Glucosamine Sulfate: I-MedlinePlus Supplements". Epreli 2011.
> Pavelka K, Gatterova J, Olejarova M, Machacek S, Giacovelli G, Rovati LC. Ukusetyenziswa kwe-Glucosamine Sulfate kunye nokukhawuleza kokuqhubela phambili kwe-Knee Osteoarthritis: u-3-Year, Randomized, Placebo-Controlled, U-Double-Blind Study .. IArch Intern Med. 2002 Oct 14; 162 (18): 2113-23.
> Thie NM, Prasad NG, Major PW. "Ukuhlolwa kwe-glucosamine sulfate kuthelekiswa ne-ibuprofen ekwenzeni unyango lwe-osteoarthritis ye-temporomandibular. J Rheumatol. 2001 Juni; 28 (6): 1347-55.
> Towheed TE, Maxwell L, Anastassiades TP, Shea B, Houpt J, Robinson V, Hochberg MC, Wells G. "I-Glucosamine Therapy yokwelapha i-Osteoarthritis." I-Cochrane Database Syst Rev 2005 2005 18; (2): CD002946.
> Vlad SC, iLavalley MP, uMcAlindon TE, uFelson DT. I-Glucosamine nge-Pain e-Osteoarthritis: Kutheni Uvavanyo Lwemvavanyo Luyahluka? Arthritis Rheum. (2007) 56.7: 2267-2277.
> Wilkens P, Scheel IB, Grundnes O, Hellum C, Storheim K. "Impembelelo ye-Glucosamine kwi-Disability-Related Related to Patients With Pain Down Back Pain kunye ne-Degenerative Lumbar Osteoarthritis: I-Trimmed Control Trial." JAMA. 2010 Julayi 7; 304 (1): 45-52.