Isizathu esiphezulu seDose Weekly
I-methotrexate isilinganisi se- rheumatoid arthritis kunye nezinye iintlobo zokuvuvukala i-arthritis kufuneka zithathwe ngeveki, kungekhona imihla ngemihla njengamanye amaninzi. Ngenxa yokuba ayifani nexesha eliqhelekileyo lonyango, lidideka ekuqaleni, ngaphandle kokuba ugqirha wakho athatha ithuba lokuchaza ngokucacileyo.
Iingcamango zenziwe zizigulane ezazicinga ukuba "ngeveki" ziyimpazamo nje yohlobo lwe-typographical kwileyibhile ye-methotrexate yesibhanki.
Ukuba unokungabaza, fownela umkhomikhali wakho uze ubize ugqirha wakho. Ukukhangela kabini okanye ukujonga isicatshulwa ukuba kukho imfuneko. Kubalulekile ukuba uyifumane. Kwamaxesha amaninzi, iZiko loKhuseleko lweMilesi ekhuselekileyo lifumana iingxelo zomlomo we-methotrexate ngokweqile ngenxa yokungabi nakwenzeka kwimihla ngemihla.
I-Weekly Dose ye-Methotrexate
I-Methotrexate yayiyimichiza yomhlaza ngaphambi kokuvunywa kwi-arthritis ye-rheumatoid. Imilinganiselo esetyenziselwa i-rheumatoid arthritis kunye nezinye izifo ezivuthayo zincinane xa kuthelekiswa naleyo esetyenziswe ngumhlaza. Ngokuqhelekileyo, abantu abane-rheumatoid arthritis baqale baqeshwe ngamaphilisi ama-2.5 milligram methotrexate (i-7.5 milligrams total) ukuba bathathwe kunye kanye ngeveki nganye, ngosuku olunye lweveki (umz., Njalo ngoMgqibelo). Njengoko kuyimfuneko, ugqirha unako ukwandisa umthamo, kodwa kusekwa ngeveki, kungekhona imihla ngemihla.
Ngokwe-rheumatologist uScott J. Zashin, MD, "Ukuthabatha i-methotrexate kanye ngeveki kunika amandla kodwa kunciphisa umngcipheko wesibindi kunye nomonakalo womnkantso wethambo." Kukhona amandla okuba nemiphumo enobungozi obukhulu, ingakumbi i-hepatoxicity, ukuba i-methotrexate iyathathwa ngephutha ngentsuku zonke.
Akufanele unyuse umthamo ochanekileyo we-methotrexate okanye utshintshe ishedyuli yokulandelela ngokwakho.
I-Methotrexate I-Optimal Dose ye-Rheumatoid Arthritis
Umtya omdala oqhelekileyo we-methotrexate kwi-arthritis ye-rheumatoid, njengoko kuchaziwe ngasentla, i-7.5 milligrams njenge-dose yeveki enye. Inokuthi ithathwe njengowamaqondo ahlukeneyo: ii-2.5 milligram ezithathwa ngomlomo nganye iiyure ezingama-12 ukuya kuma-3 amanani kunye neveki (umz., 00:00, 12:00, no-23:59 ngosuku olufanayo).
Isiqhelo esiphezulu sesonto elidala lomntu omdala we-methotrexate yomlomo ngu-20 milligrams. Umtya wesiqhelo somlomo we-matritrexate we-rheumatoid arthritis unama-milligram ama-5 ukuya kuma-15 emva kweveki nganye.
Ngokutsho kweziphumo zophando ezipapashwe kwi- Annals ye-Rheumatic Diseases , i-dose-based "dose" esekelwe "ubungqina obuphezulu" kunye neendlela zokubongoza abantu abadala abane-arthritis yesifo se-rheumatoid kubandakanya isamba sokuqala sama-milligram e-methotrexate ngomlomo ezithathwa kanye ngeveki. Lelo dosi linokunyuswa ngama-milligram emi-5 ngenyanga ukuya kwi-25-30-milligrams ngeveki okanye i-dose ebekezeleleke kakhulu. Utshintsho kwi methotrexate engenayo ingenziwa ngabantu abane-arthritis ye-rheumatoid abafumana impendulo enganeleyo ngomlomo we-methotrexate okanye abo bangenako ukunyamezela ukuqulunqwa komlomo. Kungakhathaliseki ukuba kukho utshintsho olwenziweyo, kufuneka luhlale njengedosi yeveki.
Ezinye izilumkiso zeMethotrexate
I-Methotrexate inxulumene nokunyuka kwefuthe xa kuthathwa ngamanye amayeza, njengemithi engeyiyo-anti-inflammatory (NSAIDs) , imithi ye-acid reflux kunye namanye amayeza. Ukusebenzisana okunjalo kwezidakamizwa kungabangela ubungozi obunobungozi, kwaye mhlawumbi nokufa. Qinisekisa ukuba ugqirha wakho unoluhlu olupheleleyo lwawo onke amayeza owathathayo kwaye uxubusha ukusebenzisana okunokwenzeka kunye ne-methotrexate.
I-Methotrexate ayifanele ithatyathwe ngabantu abanesifo sesibindi, isifo esibalulekileyo sesifo, utywala, ukuphazamiseka kwegazi (umz., I- anemia , i-leukopenia) okanye isifo sengqondo somongo. I-Methotrexate ayifanele isetyenziswe ngabasetyhini abakhulelweyo okanye abancancisayo. Kwakhona kufuneka kumekwe ngabasetyhini kunye namadoda aceba ukukhulelwa.
Ukuba ufumana izibonakaliso zempendulo xa uthabatha i-methotrexate, khangela unyango lwezonyango. Imiqondiso enjalo iya kubandakanya imihlathi, ukusabela kwesikhumba, ukuphefumula ubunzima, ukuvuvukala ubuso, imilomo, ulwimi, okanye umqala. Ufanele uyeke u-methotrexate uze ubize ugqirha wakho ukuba uhlakulele ukukhwehlela komzimba, ukuphefumula okufutshane, uhudo, ukuhlanza, amathanga amhlophe okanye izilonda emlonyeni wakho , igazi kumchamo okanye isitulo, ukufumana isisindo somzimba ngokukhawuleza, ukunciphisa umchamo, ukuhlutha, umkhuhlane, iimpawu zomkhuhlane, ubuthathaka, ukukhanya okulula, okanye nawuphi na uphawu olungavamile.
Iziphumo eziqhelekileyo ezichaphazelekayo kunye ne-methotrexate ziyisiphithiphithi, intloko yesisu, isisu, ukukhathala, kunye nombono ogqabileyo. Abanye abantu abafumana iziphumo eziqhelekileyo ezichaphazelekayo kunye ne-methotrexate yomlomo banokufumana i-injection methotrexate enokunyamezela.
ILizwi
I-Methotrexate ingaba yipilisi ekhuselekileyo neyisebenzayo ye-arthritis ye-rheumatoyi xa ithathwa ngokufanelekileyo. Kumele kuthathwe ngokulandelelana, ngaphandle kokuphambuka kwezo zikhokelo. Ungalokothi uthathe ngaphezu kokumiselwe kwaye ungatshintshi ishedyuli yeveki. Qaphela iziphumo ezinobungozi, ikakhulukazi iziganeko ezingathandekiyo, kwaye uzazise ugqirha ngokukhawuleza ukuba kukho into ephazamisayo.
Uya kufuneka ukuba ube neemvavanyo zelabhoratri ngezikhathi ukujonga iibalo zegazi, ii- enzyme zesibindi kunye nomsebenzi wezintso . Musa ukusela kotywala ngelixa uthatha methotrexate. Vumela ugqirha ukuba wazi ukuba uhlakulele intsholongwane echaphazelekayo. Buza ugqirha wakho malunga nokuthatha ii-antibiotiki zentsholongwane. Kwakhona kubalulekile ukuxoxa ngegonyana nogqirha wakho. Abantu abathatha amanani aphezulu a methotrexate mabaphephe iigciwane eziphilayo. Ngaphantsi-ukusetyenziswa okukhuselekileyo kwe-methotrexate, kufuneka ulandele ngqo izikhokelo kwaye uqaphele izilumkiso kunye nezilumkiso. Thetha ngokugqithiseleyo nodokotela wakho malunga nantoni na ehlala ingacacile, okanye nayiphi na into ephathelele kuwe.
> Imithombo:
> Nangona i-Low-Dose Methotrexate Ingabangela Ubungozi okanye Ukufa xa kuthathwa imihla ngemihla okanye ngezinye iiMithi. ConsumerMedSafety.org. Novemba 30, 2015.
> Methotrexate. Drugs.com. Ukuhlaziywa ngo-Agasti 4, 2015.
> Visser K. et al. Isisombululo esifanelekileyo kunye neNdlela yoLawulo lwe-Methotrexate kwi-Arthritis ye-Rheumatoid: Uhlolo lokuHlola lweeNcwadi. Iziganeko zeeRheumatic Diseases. Julayi 2009.