I-Genetics & Clustering kwiintsapho
Umbuzo:
Ngaba i-Fibromyalgia Hereditary?
Abantu abaninzi kwintsapho yam baye babe ne- fibromyalgia kwaye ngoku ndibonisa ezininzi iimpawu. Oku kwenza ukuba ndikhathazeke ngokwenene ngamabantwana am-ngaba ndiye ndawachitha? Ngaba i-fibromyalgia ifa? "
Impendulo:
Oku kukuxhalabisayo. Kuyatshwenyeka ukuba sicinge ukuba sinokungazi, singazi kakuhle, sidlulisele isigulo esingasigxina, esiyingoziyo kunye nabantwana bethu.
Iindaba ezilungileyo kukuba ngelixa banokuba neengozi ephezulu, abaqinisekanga ngokupheleleyo ukuphuhlisa i-fibromyalgia.
Ngokusekelwe kuphando, inkolelo yangoku kukuba i-fibromyalgia ayinalo ifa ngokwemvelaphi yeklasi, apho ukuguqulwa komzimba omnye kujongene nomlinganiselo othile. Oko kubizwa ngokuthi i-monogenic, kwaye ilawula izinto ezifana nombala wamehlo aluhlaza okwesibhakabhaka; Nangona kunjalo, ubungqina bubonisa ukuba izifo zakho zengqondo ziyakunceda ukuba usebenzise i-fibromyalgia, kodwa ngendlela enzima ebandakanya iindiza ezininzi, ezibizwa ngokuba yi-polygenic.
Yintoni eyahlukileyo?
Kwimeko yeklasiki, i-monogenic, ifa, i-gene ekhethekileyo evela kubazali bakho iyona nto ibalulekileyo ekufuneka ufumane isifo. Ngokomzekelo, kwi-cystic fibrosis, umntwana wabantwana abathwala izifo zombini uneepesenti ezingama-25 zokuphuhlisa i-cystic fibrosis. Bafumana ukuguqulwa kwezinto eziphathekayo okanye abayiyo. Ukuba bafumana utshintsho, bafumana isifo.
Ngobuninzi be-polygenic, ayilula nje ngokuba iizitho zakho zentsholongwane zithetha ukuba isifo esithile singenzeka phantsi kweemeko ezifanelekileyo . Oko kuthetha ukuba kukho umngcipheko ophezulu kunabanye abantu, kodwa kungekhona ukuqinisekiswa. Ngokuqhelekileyo, ezinye izinto kufuneka zenzele ekubangela ukuba ugula.
Kwi-fibromyalgia, le miba ingabandakanya:
- neminye imithombo yeentlungu ezingapheliyo
- isifo
- izifo zokulala
- uxinzelelo olungapheliyo
- kugula
- ingqondo engavamile
Ezinye iingcaphephe zixhomekeke ekubeni izinto eziphathekayo zendalo ezifana nokukhathazeka kokutya okanye ukuchazwa kwezidakamizwa zinokudlala indima.
Oko kuthetha ukuba umntwana wakho unokufumana i- fibromyalgia engumgubo wokuzalwa , kodwa oko akuthethi ukuba uya kuphelisa. Kuya kuthatha isethi esongezelelweyo seemeko zokubamba phantsi loo ndlela.
I-Genetic Links kwi-Fibromyalgia
Abaphandi baqala ukukhangela i-fibromyalgia eyadlulayo kwixesha elidlulileyo elidlulileyo kuba lihlala ligijima kwiintsapho, kwizinto ezibizwa ngokuba "ngamaqela." Ubuninzi bomsebenzi ubandakanye amawele afanayo. Umzimba wophando ukhule ukusuka kuma-1980.
Oko esikufundileyo kukuba malunga nesiqingatha somngcipheko onqunywe yi-genetics kunye nesiqingatha kunqunywe ezinye izinto ezifana nezo zidweliswe ngasentla.
Uphando luqinisekisa ubungqina obuphezulu kwimizalwane kwaye lubonisa ukuba umlinganiselo weentlungu eziphantsi (indawo apho ubuhlungu buya kuba buhlungu) buqhelekileyo kwiintsapho ezingenalo i-fibromyalgic zabantu abane-fibromyalgia.
Sitsho nje ukuqala ukufumana umfanekiso wezinto ezithile zofuzo ezinxulumene ne-fibromyalgia.
Kuze kube ngoku, sifunde izifundo ezininzi ezibonisa ukudibanisa ngeendiza ezininzi, kodwa ezininzi zezi zifundo azange zichazwe.
Izifo ezingaqhelekanga ezicetyiswayo zifundo zibandakanya izakhi zemizimba ejongene neurotransmitters (iikhemikhali izithunywa kwingqondo) eziye zaxutyushwa kwi-fibromyalgia, kubandakanya i- serotonin , i- norepinephrine , i- dopamine , i- GABA kunye ne-glutamate . Abanye babandakanyeka emsebenzini wengqondo jikelele, ukulwa nokusuleleka kwintsholongwane, kunye nabamkeli beengqondo ezijongene ne- opioids (ababulali beentlungu) kunye ne-cannabinoids (njenge- marijuana .)
Njengoko sifunda ngokubanzi malunga nemibutho yemfuzo, abaphandi banokuchonga ukuba yeyiphi na inxaxheba ebangela umngcipheko wokuphuhlisa i-fibromyalgia kunye nokuba ingaba isiphi na isingasetyenziswa ukuxilonga okanye ukunyanga imeko.
Yintoni Ethetha Ngomntwana Wakho?
Kunomngcipheko ukucinga ukuba umntwana wakho unengozi enkulu yokuphelisa i-fibromyalgia. Into ebalulekileyo yokukhumbula kukuba akukho nto iqinisekisiwe.
Okwangoku, asazi oko kunokunceda ukunciphisa umngcipheko, kodwa olunye uphando lubonisa ukuba iimbini ezinengqondo ephakamileyo yeemvakalelo zazingenakukwazi ukugula. Ubulumko bakho bunokwakho:
- ukuba uqaphele kunye nokulawulwa kwemizwa yakho
- ukubonisa indlela ozivakalelwa ngayo
- ukujongana nolwalamano olufanelekileyo kunye novelwano
Ukukhuthaza ezo zakhono kumntwana wakho kunokunceda. Ukuxinezeleka kwakhona kuyimbangela yokuxhalabisa, ngoko zama ukufundisa umntwana wakho ngendlela efanelekileyo yokujongana . Ukuba umntwana wakho ubonakala enzima naziphi na ezi zinto, unokufuna ukucebisa umcebisi onobungcali onokumncedisa.
Ngenxa yokuba ubuhlungu obungapheliyo obukhona ngaphambili bubuncipheko be-fibromyalgia, unokufuna ukwazi ngokukodwa ukulimala kunye nokuba umntwana wakho unemigraine okanye "ubuhlungu obukhulayo". Udokotela wakho wezilwanyana kufuneka abe nako ukuncomela unyango.
Asinalo ubungqina bokuba ukutya okunempilo kunye nokuzimela ngokusemgangathweni komzimba kukunciphisa ingozi yomntwana wakho wokuphuhlisa i-fibromyalgia, kodwa ihlala isilungileyo.
Ukuba unenkxalabo malunga nantoni na enxulumene nempilo yengane yakho, qiniseka ukuba uyinyusa kunye nezingane zakho.
Yaye khumbula ukuba awuzange "utshabalalise" umntwana wakho nantoni na. Enyanisweni, ukuqonda kwakho kwasekuqaleni kungaba yiloo nto ebenza baqhube kwelinye icala.
Imithombo:
Becker RM, kunye. al. Revista brasileira de reumatologia. 2010 Dec; 50 (6): 617-24. Umbutho phakathi komgangatho wokusingqongileyo, uxinzelelo kunye ne-APOE ye-gene ukuhluka kwi-fibromyalgia yokuzimisela ukuzimisela.
UBurri A, uLachance G, uWilliam F. Twin uphando kunye ne-genetics yabantu. 2015 Umhla; 18 (2): 188-97. Indlela yokungahambisani ne-monozygotic-wtin kwiimeko ezinobungozi obungaphantsi kwintsholongwane engapheliyo kwabesetyhini.
Matsuda JB, et. al. Revista brasileira de reumatologia. 2010 kuMbhi; 50 (2): 141-9. I-serotonin receptor (5-HT 2A) kunye ne-catechol-O-methyltransferase (COMT) i-polymorphisms ye-gene: iziphumo ze-fibromyalgia?
I-Reeser JC, kunye. al. I-PM & R: iphephancwadi yokulimala, umsebenzi kunye nokuvuselelwa. Ngo-2011 uMar; 3 (3): 193-7. I-Apolipoprotein e4 i-genotype ibangela umngcipheko wokutshatyalaliswa kwesifo se-fibromyalgia posttraumatic.
Xiao Y, W W, Russell IJ. Journal of rheumatology. 2011 Juni; 38 (6): 1095-103. I-polymorphisms ye-Genetic ye-receptor ye-beta2-adrenergic ihambelana ne-guanosine protein-coupled receptor disys function in fibromyalgia syndrome.