Kutheni i-IgE ibalulekile kwaye iyakuthinta njani i-asthma ye-allergen?
I-Immunoglobulin E, okanye i-IgE, yinto engokwemvelo emzimbeni odlala indima ebalulekileyo ekuphuhliseni isifo se-asthma. Amanqanaba okwandisa i-IgE angakhokelela xa ukhankanywa kwizinto ezibangela, njenge:
Kwakhona, amazinga okwandiswa kwe-IgE anokufaka isandla kwiimpawu ezilandelayo:
Xa ufumene izifo ezithile, umzimba wakho ukhulula i-IgE, ebopha iintlobo ezininzi zeeseli, njenge:
Xa i-IgE ibopha nayiphi na iileli, inokuvuselela isistim somzimba sakho , yenza ukuba uhambo lwenu lube luncipha kwaye lube lukhuni, kwaye wenze iimpawu zakho ze- asthma zibe zibi nakakhulu.
Ukuhlolwa kwe-IgE
Ngenxa yokuba i-IgE ingaphakanyiswa kwisifo se-asthma , ukuvavanya inqanaba lakho le-IgE kunceda ugqirha wakho ukuba acinge ukuba uza kuxhamla kunyango ukuze unciphise izinga lakho le-IgE. Ukuze uhlolisise izinga lakho le-IgE, ugqirha wakho uya kuyala uvavanyo olulula lwegazi. Ngenxa yoko, lo vavanyo luyakwazi kakhulu ukuphakanyiswa kwabantwana abane-asthma ukususela ekubeni uninzi lwe-asthma olukhulayo luya kuba lula "ukungena ngaphakathi" okanye ukungabikho kwesifo se-asthma.
Ukuba unokulawula kakubi i-asthma, unokufuna ukuthetha nodokotela wakho ngokufumana izinga lakho le-IgE elivavanywe. Ungaphinda ufune ukuxoxa ngeendlela onokuziphepha ezinokukhupha i- asthma ezinokunyusa amanqanaba akho e-IgE.
Kwaye, ngenxa yokuba inqanaba lakho le-IgE liphakanyisiwe, akusiyo ingozi yokuxilongwa kwe-asthma. Nangona kunjalo, kwandisa umngcipheko wokuba nesifo esithile.
Iimpawu ezibonisa ukuba kubangelwa iimeko ezinobungozi zibandakanya amehlo enamehlo, isicupunu, ukukrazula, ukukhwehlela kunye nokudibanisa. Oogqirha abaninzi abanokuthi bangabikho ubungqina bokungabikho komzimba ngaphandle kohlobo oluthile lokuvandlakanywa ngumntu ongu-allerger (okanye ubuncinci bokuvavanywa kwesikhumba).
Qaphela ukuba ezinye izifo zingakhokelela kwizinga eliphezulu le-IgE, njenge-parasite. I-allergenic bronchopulmonary aspergillosis, i-hypersensitivity kwi-fungus yomhlaba ebizwa ngokuba ngu- Aspergillus fumigatus , kunye ne-Churg-Strauss yesifo, uhlobo lwe-vasculitis okanye ukuvuvukala kwemithambo yegazi, zizinto ezibini eziqhelekileyo zezizathu zezinga eliphezulu le-IgE. Ngamanye amaxesha abantu baya kuba nezinga eliphakamileyo ngaphandle kwesizathu esibonakalayo.
Ukongezelela, inqanaba eliphezulu le-IgE ayikho inkcazo yezinto ezinokukhokelela kwisifo se-asthma. Uya kufuneka ufumane uhlobo oluthile lokuvavanyelwa ukuvavanya ukuqonda ukuba yintoni enokubangela isifuba sakho se-asthma.
Ukwelashwa kwe-IgE
Kukho unyango olwa-anti-IgE obizwa ngeXolair (omalizumab). Unokufumana inzuzo kwi-anti-IgE unyango ukuba:
- Uneminyaka engaphezu kwe-12
- Yenza i-modem ukuya kwi- asthma eqhubekayo
- Ukunyamezela ukunyamezela unyaka wonke
- Awufumananga ukukhulula nge-steroids kunye neyezinye iindlela zokwelapha
- Unqanaba legazi le-IgE ephakamileyo
Ukuba awukwazi ukufumana iyeza okanye ungakufanelekeli yinshurensi yakho, inkqubo yeziyobisi iya kukwazi ukubonelela. Kwakhona kubalulekile ukuba i-Xolair ayibonakaliswe kunyango lwe-asthma.
Kufuneka uqaphele nemiphumo echaphazelekayo ye-Xolair equka impendulo ye-injection site, iintsholongwane zentsholongwane eziquka izifo eziphezulu zokuphefumula, intloko yesifo, kunye nomqala.
Kukho ukuxhalabisa malunga ne-anaphylaxis (isifo esibi kakhulu), ngoko, ngelixa unqabile, kufuneka uxoxe ukuba okanye awuyidingi i-epinephrine auto-injection ukuba ifumaneke ngamaxesha onke.
Kwakhona kukho ukuxhalaba malunga nomnxeba onokuthi unomdlavuza usebenzisa i-Xolair. Nangona kunjalo, ukuhlaziywa kuka-2014 kwezigulane eziphathwe ubuncinane ubuncinane iminyaka emihlanu akufumananga umahluko kwimilinganiselo yomhlaza phakathi kwezilwanyana ze-Xolair kunye nabangaphathwa nge-Xolair.
Imithombo:
I-Heart Heart, i-Lung, ne-Blood Institute. Ingxelo yePhaneli yeNgcali 3 (EPR3): Izikhokelo zoLwazi kunye noLawulo lwe-Asthma
I-Asthma ne-Allergy Foundation yaseMelika. Ulwazi lwaBathengi. Indima ye-IgE Kwi-asthma ye-allergen