Umsebenzi weNgcaciso yeGazi kwiMveliso ye-Histamine
I-Basophil enye yeentlobo eziqhelekanga zeeseli zegazi ezimhlophe ezikhonza njengenxalenye yesimiso sethu somzimba . Bakhawula kuphela ngeepesenti enye zeeseli ezimhlophe zegazi zidlala indima ephambili ekuzikhuseleni komzimba.
I-Basophil yenza imisebenzi emininzi ebalulekileyo. Yenza i-heparin ekhusela igazi ukuba liphume ngokukhawuleza kwaye "lingadla" iipasasites ngokusebenzisa inkqubo ebizwa ngokuba yi-phagocytosis.
Kodwa mhlawumbi inendima ebaluleke kakhulu abayidlalayo kwiindlela ezithile zokuvuvukala, ingakumbi ezo zibandakanya ukunyuka.
Basophils kunye neAirgy
I-Basophil iyingxenye yesistim e-immune system esenza ukuba umntu angaboni nantoni na into enokuthi inomzimba ibona ingozi. Ngokungafani nokuzikhusela komzimba, okubangela impendulo ekujoliswe kuyo, iziphumo zokuzikhusela ezingenangqondo ekuhlaselweni jikelele. Xa oko kwenzeka, umzimba unokufumana ukuvuvukala, uhlobo lokuzikhusela oluvame ukubonakalisa ukuvuvukala, intlungu, umkhuhlane kunye nokukhathala.
Ukongezelela oku, i-basophil ivelisa into ebizwa ngokuba yi-histamine ebangela ukuba imivenge yegazi ihlaziye ukuvumela iisensi ze-immune ezikhuselekileyo zisondele kwisiza sosulelo.
Kodwa oku akusiyo kuphela ixesha xa i-histamines iveliswa. Xa umzimba uvelele kwizilwanyana ezithile, isistim somzimba singakwazi "ukuphendula ngokuphindaphindiweyo" kwaye siqalise ukukhululwa kweembamamine, kubangele ukuvuvukala, ukunyunyuza, kunye neengxaki zokuphefumula esizibandakanya nayo.
Umbutho Phakathi kwamaSasophil kunye neMpawu zeAsma
Inani le-basophil egazini lingahluka. Xa inani liphantsi kakhulu, sithetha ukuba umntu unesiseko. Xa uphakamileyo kakhulu, umntu unalo isophilia. I-Basophilia yinkxalabo ekhethekileyo kubantu abane-asthma njengenyuka kwiinombolo ze-basophil ziyakwazi ukuguqulela ukuveliswa kwembali ye-histamines.
Ukuthetha ngokuqhelekileyo, i-basophilia ayiqhelekanga kodwa enye inokuvela kubantu abanezifo ezithile zentsholongwane okanye i-virus, isifo sikashukela, i-rheumatoid arthritis, i-eczema, okanye i-hypothyroidism. Ngenxa yokwanda kwamanani eeseli, i-basophilia inokudityaniswa nokugqithisa kweempawu kubantu abane-asthma. Ezi ziquka:
- Ukuvutha okukhulu kwemiphunga
- Ukugqithisa kweendinyana zomoya (i- bronchoconstriction ), okubangelwa ukuqhuma, ukuqina kwesifuba nokuphefumula
- Ukuveliswa kwemveliso ye-mucus, okwenza ukukhwehlela kunye nokukhutshwa komphefumlweni
I-Basophilia nayo ibonakala ngokubonakalayo kwizifo ezinjenge-atopic dermatitis, isifo sesisu se-inflammatory (IBD), i-hemolytic anemia, i-lemonemia engapheliyo kunye ne-Hodgkin.
Indima ye-Basophil ekulawuleni i-Asthma
Ngoxa ihlala ingacacile ukuba yintoni indima, ukuba ikhona, ukuhlolwa kwe-basophil yeklinikhi (BAT) ingaba nokuxilongwa okanye isifo se-asthma. Nangona kunjalo, igxininisa imfuneko yokuqhubela phambili uphando ukuze kuqondwe iinkqubo ze-molecular astmma kunye ne-allergies. Ngokwenza njalo, unyango olutsha kunye nemithi yokwesekwa lunokuphuhliswa (kubandakanye iindlela zokususa impendulo ye-basophil-histamine).
Oko esikwaziyo yile: ngonyango olufanelekileyo kunye nokubeka esweni rhoqo kwimpilo yomntu, iimpawu eziqhubekayo ze-asthma zinokuncitshiswa okanye zithintelwe.
Ngokwahlukileyo, i- asthma elawulwa kakubi (ebangelwa ukungena ngokwaneleyo okanye ukunyanzeliswa kakubi kwonyango) kunokukhokelela kumonakalo osisigxina kunye nangomonakalo wamaphaphu.
Ekugqibeleni, indlela efanelekileyo yokunyusa i-asthma yonyango kukugcina impilo enempilo , kwaye kubandakanya ukutyelela rhoqo ugqirha wakho.
> Imithombo:
> Hoffmann, J .; Knol, E .; Ferrer, L .; okqhubekayo. "Iinkonzo kunye nokuxhamla kwe-Clinical Testing Basophil (BAT)." Iingxelo zeNtsholongwane kunye neengxelo ze-Asthma . 2016: 16 (8): 56.
> Siracusa, M .; Kim, B; Spergel, J .; kunye no-Artis, D. "i-Basophils kunye ne-Downergic Inflammation." I-Journal ye-allergies kunye ne-Clinic Immunology . 213. 132 (4): 789-801.