Isizathu sokuba Sinamandla Amandla kunye nendlela yokulwa nayo
Into ethile ye- fibromyalgia (i-FMS) kunye nesifo esingapheliyo sisifo ( ME / CFS ) esivumelanayo kukungabikho kwamandla. Okuhluke ekukhathaleni okanye ukungabikho kokushukumiseka okungaza kukudakumba. Singafuna ukwenza into kodwa singakwazi ukuyenza.
Okokuqala, akufani nokukhathala nokufuna ukulala. Ingaphezulu yethambo-ediniweyo, ayikwazi ukuhambisa umuzwa wesisu.
Ukuba uye wakha waya kwinqanaba lokuba awukwazi ukwenza kwakhona, kungakhathaliseki ukuba ufuna kangakanani, yiloo nto esiyithethayo. Ukuba uye waphuma kwi-anesthesia kunye neenqwelwe zakho ezinzima kakhulu ukuphakamisa, uyifumana. Unokufuna ukulala, kodwa ufuna ukuba uphumle imisipha yakho ngaphambi kokuba wenze enye into.
Nangona i-FMS kunye ne-ME / CFS, nangona kunjalo, ukungabikho kwamandla kungabetha ngokukhawuleza kwaye kuphele ixesha elide, kungakhathaliseki ukuba sihlala ngaphi. Kungenzeka kwenzeka phakathi kohambo lokuthenga, emsebenzini, okanye imizuzu elishumi emva kokuphuma ebhedini. Kungenzeka nokuba kubekho into yokuqala ekuseni kwaye ugcine ungakhange uvuke.
Asiyiqondi ngokupheleleyo le mpawu okanye ukuba kutheni iyingxenye zezi zifo, kodwa uphando lubonisa ukuba, ubuncinane inxalenye, ngenxa yamanqanaba aphantsi okuthiwa yi-adenosine triphosphate, okanye i-ATP.
Yintoni i-Adenosine Triphosphate?
I-ATP igcina amandla emzimbeni wakho.
I-Biologists idla ngokuba yiyona "yindleko yobomi." Ingumthombo omkhulu wamandla kuzo zonke iiseli eziphilayo. Yilokho amandla ekutya kwakho aguqulwa ukuba abe nako ukwenza zonke iinkqubo zomzimba wakho.
I-ATP ikhiqizwa yi- mitochondria kwiiseli zakho. Iiseli zakho zidinga ukuba zisebenze, imisipha yakho iyidinga ukuba inkontileka, yonke into emzimbeni wakho iyayidinga ukwenzela ukuba yenza njengokuba kufuneka.
I-Adenosine ivela ngokwemvelo emzimbeni wakho kwaye, phakathi kwezinye izinto, ihambelana nomgaqo wokuhamba kwegazi kwezinye izitho zakho. Xa kuziwa kwi-ATP, nangona kunjalo, yinxalenye ye-triphosphate ebaluleke kakhulu.
Ukwenza i-ATP, i-adenosine idibene namaqela amathathu e-phosphates. Xa amandla adingekayo kwindawo ethile kwaye i-ATP ithunyelwe, enye yezo phosphates iyaphulwa, ikhulule amandla. Emva koko umzimba wakho ubeka endaweni ye-phosphate ukuze kuphinde idale i-ATP. Yinkqubo yokuphinda ibuyiswe kwakhona.
Xa izibhloko zokwakha ze-ATP azifumaneki kumzimba wakho okanye into ephazamisa inkqubo yokubuyisela, ii-ATP zinokuthi zibe ziphantsi kwaye zibangele ukusilela kwamandla.
Ulwaphulo lwe-ATP kwi-Fibromyalgia
Asinayo itoni yocwaningo malunga nenxaxheba ye-ATP kwi-FMS, kwaye izifundo esinazo zincinci. Ngethamsanqa, zihamba kakuhle ngokubonisa ukuba ama-ATP amanqanaba aphantsi kule meko.
Uphando lwaseYurophu olupapashwe ngo-2013 lubonise ukulungiswa phakathi kokunciphisa amandla omzimba kwizandla kunye neenyawo kwi-FMS kunye neendawo eziphantsi kakhulu ze-ATP kunye ne-phosphocreatine, efana nengxowa ye-phosphate into eyenziwa ngumzimba wakho ukugcina inkqubo yokubuyisela ngokutsha njengoko ishisa amandla .
Umsebenzi wangaphambili wafumanisa amanqanaba aphantsi e-ATP kwiiplatelets zabathathi-nxaxheba kunye ne-FMS kunye nezinye izinto ezingavumelekanga ezibonisa ukuba umzimba awukwazanga ukugcina imali ehambelana ne-ATP.
Ngoko ngelixa umzi womsebenzi ubonakala ufumanisa ukusilela, kwaye ukungafumani kuthiwa kudlala indima ekungabikho kwamandla, oko yinto sonke esinokuyithetha ngoku.
Ulwaphulo lwe-ATP kwi-ME / CFS
Kwi-ME / CFS, i-ATP iye yafumana ingqwalasela engakumbi kubaphandi, mhlawumbi ngenxa yokuba ukungabikho kwamandla kubaluleke kakhulu kwiM ME / CFS kunokuba ku-FMS, apho kugxininiswe khona intlungu.
Izifundo ezincinane ze-ME / CFS ezijongene nomsebenzi we-mitochondrial kwiiseli ziye zaxhasa inkolelo ekhulayo yokuba amanqanaba aphantsi okuvelisa i-ATP esuka kwi-mitochondrial dysfunction, oku kuthetha ukuba iibhloko ezakhiwayo zeseli azisebenzi kakuhle.
Esinye sezibonakaliso eziphawulekayo ze-ME / CFS yi -malaise emva kokunyusa , okuyiyo engafanelekanga kunye nokugqithisa ngokugqithiseleyo iimpawu emva kokuzikhandla. Isixa sokunyusa sithatha uhlukahluka ngumntu, kodwa sishiya singakwazi ukwenza umlinganiselo ofanayo nomhla olandelayo, ongenqabileyo kwaye oyingqayizivele kwesi sifo.
Iphepha le-2015 lidibana ne-post-exertional malaise kumazinga aphantsi aphantsi kwe-ATP ngenxa ye-adenosine engonelanelekanga, ebonisa ukuba ixesha lokubuyisela ixesha elide likhona kuba umzimba kufuneka uqale ufikelele kwi-adenosine, kwaye emva kwe-ATP.
Inqaku elihlaziyiweyo elipapashwe ngo-2014 lisekela le ngcamango, nabaphandi badibanisa iimpembelelo kwi-ATP ukuvelisa ukuba kungabikho kuphela ukuxiliswa kwe-malaise, kodwa mhlawumbi ukuqala kwesi sifo ngokwaso kunye nokungaqhelekanga okunamandla okuhambelana nayo. Ababhali beli phepha baphinde baveza ukuba ukuveliswa kwe-ATP ephantsi kwi-ME / CFS kunokukhokelela ekuziphatheni ngokwasemzimbeni ngokusebenzisa impembelelo ekufeni kweeseli.
Ukunyangwa kwe-ATP
Iyeza zonyango eziqhelekileyo ezichazwe kwezi zigulo azikwazi ukujongana nokukhubazeka kwemithachondrial okanye ukusilela kwe-ATP. Nangona kunjalo, oogqirha abathile baphumelela ngempumelelo kunye nezibonelelo ezikholelwa ukuphucula ezi ngxaki. Ezinye zalezi zongezelelo zenza uphando oluncinane ubuncinane bokuba kukho ubungqina babo.
Mhlawumbi uvile nge- coenzyme Q10 (CoQ10) , eyenzeka ngokwemvelo emzimbeni wakho kwaye inokuthi ithathwe njengesongezelelo. Iyaziwayo phakathi kwabantu abane-FMS, ME / CFS, kunye nezinye iimeko, kunye nempilo jikelele. Ngokwengxenye, okokuba umzimba wakho udinga i-CoQ10 ukwenza i-ATP.
Izifundo eziliqela ezibandakanya i-FMS kunye / okanye i-ME / CFS iqhagamshelanisa amanqanaba aphantsi kwe-ATP kunye ne-CoQ10. Ucwaningo oluninzi lubonisa ukuba ii-coQ10 zongezelelo ziphucula amandla kule miqathango. IziQinisekiso zeCQ10 zi:
- phucula amandla
- ukunciphisa i-malaise post-exertional malaise
- ukunciphisa ukukhathala
- kunciphisa intlungu yokukhulisa (hyperalgesia) yeFMS
Ezinye izilwanyana ezicetyiswa ngamanye amaxesha ezicetyiswayo ukukhubazeka kwe-mitochondrial ziquka:
Ugqirha wakho unokukwazi ukucebisa ezinye iindlela zokuphucula amandla akho ngokuphakamisa amanqanaba e-ATP.
Khumbula ukuba izinto zendalo zingabangela iziphumo ezibi kunye nokungahambisani kakubi nezinye izinto ozithathayo. Qiniseka ukuba uthethe ugqirha wakho malunga nayiphi na unyango onomdla kuyo ngaphambi kokuba uqale, kwaye qi ni sekise ukuba uyazi indlela yokuphepha ngokutsha ngokutsha .
> Imithombo:
> Gerdle B, iForsgren MF, uBangtsson A, et al. Ukunciphisa imizimba ye-ATP kunye ne-PCR kwisifo se-quadriceps yezigulane ze-fibromyalgia-Uvavanyo lwe-31P-MRS. Umbhalo waseYurophu weentlungu. 2013 Sep; 17 (8): 1205-15.
> Lengert N, Drossel B. Kuhlalutyo lwe-silico yokunyamezela ukungasebenzi kwi-myalgic encephalomyelitis / isifo esingapheliyo. Chemistry. 2015 Julayi; 202: 21-31.
> Morris G, Anderston G, Berk M, Maes M. Coenzyme Q10 ukuphazamiseka kwintsholongwane kunye neuropsychiatric disorders: iziphumo ezinokubakho kunye neempembelelo zonyango. I-molecular neurobiology. 2013 Dec; 48 (3): 883-903.
> Morris G, Berk M, Galecki P, Maes M. Indima ekhulayo yokuzimela komzimba kwi-myalgic encephalomyelitis / chronic fatigue syndrome (ME / cfs). I-molecular neurobiology. 2014 kuMbhi; 49 (2): 741-56.
> Morris G, Maes M. Izidakamizwa zeMitochondrial kwi-myalgic encephalomyelitis / chronic fatigue syndrome echazwe yimigudu yokugonywa kwamandla omzimba, okuyi-oxidative kunye ne-nitrosative. Izifo zobuchopho. 2014 Mar; 29 (1): 19-36.