Ingxaki ye-bipolar yimeko enzulu yengqondo eyenza abantu bafumane ukuguquka okukhulu kweemania ukusuka kwi-mania ukuya kuxinzelelo. Ukugula kungaphathwa ngamachiza kunye nabantu abane-disiphagence disorder nabo banokufumanisa ukuba ukululekwa kunokunceda.
Akuqhelekanga ukubona iziganeko kwizifo ze-celiac / i-gluten zengqondo ezivela kubantu abane-bipolar disorder ababika ukuba iimpawu zabo ziphuculwe okanye zize zatshatyalaliswa ngokupheleleyo xa zifumene ukutya okubangelwa i-gluten .
Ukongezelela, izifundo ezimbini kwiincwadi zonyango zibonisa ukuba abantu abanesifo se- celiac okanye ubuninzi be-gluten bentlukwano banokubangelwa yimilinganiselo ephakamileyo ye-bipolar disorder kune-general population.
Nangona kunjalo, njengezona zinxibelelwano ezinokwenzeka phakathi kokungenwa kwe-gluten kunye neemeko zengqondo, uphando olungakumbi luyimfuneko ngaphambi kokuba lube lucacileyo ukuba ukulandela ukutya okungekho gulen kunokunceda abanye abantu abaneengxaki zokuguquka kwe-bipolar.
Anti-Gluten Antibodies ezifumaneka kubantu abane-Bipolar Disorder
Okwangoku, zifundo ezintathu zonyango zenzelwe ukujonga ukuba abantu abaneengxaki ze-bipolar baye baphakamisa amanqanaba e-anti-guten antibodies kwiimida zabo zegazi.
Kwisifundo esiphezulu kakhulu, eshicilelwe ngo-2011, abaphandi bavavanya abantu abangama-102 abaneengxaki zokugula ngengqondo kunye nabantu abangama-173 abangenayo ingxaki yesifo sengqondo. Balinganisa amanqanaba eengqungquthela ze-AGA-IgG kunye ne- AGA-IgA , ezo zombini ezingekho ngqo kwisifo se-celiac kodwa ezingasetyenziselwa iimvavanyo zentswelo ye-gluten .
Baye balinganisa ama-antibodies e- diamidate ku-TTG-IgA kunye ne-TTG-IgG, abavavanyelwa ukuhlolwa kwezifo ezilukhuni .
Uphononongo lufumene ukuba abantu abaneentsholongwane ze-bipolar babe nomngcipheko omkhulu kakhulu wokuba neenqanaba ezikhulayo ze-IgG antibodies ukuba i-gluten xa kuthelekiswa nalabo abangenayo i-bipolar. Nangona abantu abaneengxaki ze-bipolar bafumana iziganeko eziphezulu zezinye i-laboratory iziphumo ezihambelana nezifo ezingenayo i-celiac, ezo ziphumo azizange zibaluleke.
Amanqanaba e-antibodies kubantu abanesifo sengqondo sokuphazamiseka kwengqondo awazange ahambelane neempawu zabo ezipheleleyo (ezilinganiselwe iindlela ezahlukeneyo), imbali yabo yezokwelapha, nokuba banayo impawu yesisu, okanye kunye nokusetyenziswa kwazo kwemithi ethile yengqondo.
Phantse isiqingatha salabo abaneengxaki ze-bipolar ezithwala izifo zesifo se- ecliac (oko kukuthi, iigleji ezikubeka phambili kwisifo se-celiac), kodwa abo abanamajethi abazange banako ukunyuka kwama-antibodies.
Isifundo sesibini sibona iMania kwi-Bipolar ne-Gluten Antibodies
Iqela elifanayo labaphandi lanyathelisa uphando ngo-Matshi 2012 ngokukhangela amanqaku obuninzi be-gluten kunye nesifo se-celiac kwi-mania ephawulekayo, uphawu oluphawulekayo lwe-bipolar disorder. Bafumene ukuba abantu ababhedlele kwizibhedlele be-mania baye bandula amanqanaba amaninzi e-IgG ku-gluten, kodwa abazange bakhulise amanqanaba kwezinye iindidi ze-antilidies ze-celiac.
Okuthakazelisayo kukuba, xa kuqhathaniswa neenyanga ezintandathu emva kokubhedlele, izigulana zokugulisa izigulane ze-bipolar ziye zahla kwaye zazingekho ezahlukeneyo kwezo zifundo. Nangona kunjalo, ezo zigulane eziphazamisekileko eziye zaphakamisa amanqanaba e-IgG kwiinyanga ezintandathu kamva zazinokwenzeka ukuba ziphinde zifakwe esibhedlele ngenxa ye-mania ngaphakathi kwelo xesha.
Abaphengululi baphetha ngokuthi "ukubeka iliso nokulawulwa kwentlupheko ye-gluten kunokuba nemiphumo ebalulekileyo ekulawuleni abantu ababhedlele esibhedlele.
Uphando lwesithathu, olushicilelwe ngo-2008, aluzange lukhangele ngqo kwi-bipolar disorder kunye ne gluten; Kunoko, ubujonge kwiimeko ezininzi zeengqondo, kubandakanya ukukhubazeka kwe-bipolar, nokuba ingaba kwenzeka kakhulu kubantwana abanesifo esiqhekezayo okanye ngokuvavanywa kwegazi elihle. Uphononongo lufumene iingxaki zeengxaki zeengqondo okanye zeengqondo malunga no-2% wabantwana abane-senicity okanye gluten uzwela, izinga elingaphezulu kwe-1.1% efumaneka kwizifundo zolawulo.
I-Gluten echaphazelekayo kwezinye izifo zengqondo
Akungabazeki ukuba abantu abanesifo esiqhekezayo kunye nobuthakathaka be-gluten babhekana nezinga eliphezulu lokuxhalabisa nokuxinezeleka.
I-Gluten kunye nokuxinezeleka kudibaniswa kwizifundo ezahlukeneyo, kubandakanywa uphando olujongene nezifo ezingenasifo kunye nophando olujongene novelwano olungenanto lwama-gluten. Okwangoku, i-gluten kunye nexhala libonakala liba nolwalamano. Sekunjalo, akucaci ukuba i-gluten ngokwayo ingabangela iimpawu zokudandatheka kunye nokuxhalaba, nokuba ingaba ezinye iindlela ezifana nokusilela kwondlo ngenxa yokulimala kwamathumbu emathunjini kungabangela ezo zifo zengqondo.
Nangona kunjalo, uphando oluthile lufumene ukuba ukubambelela kwisondlo esingenasiphelo se-gluten kubonakala kunceda ezinye iimpawu zoxinzelelo kunye nokuxhalabisa kubantu abanezifo ezingenakuqhafaza kunye nobutyebi bendalo.
Iingcali zengqondo ziye zacatshulwa malunga nokunxibelelana okuphakathi kwe-gluten kunye ne-schizophrenia, kwaye ezinye iingxelo zibonisa ukuba kukho abantu abane-schizophrenia abanokuphucula kwi-gluten-free food. Nangona kunjalo, iingcali zempilo yengqondo zisola ukuba inani labantu abanokuphucula lincinci kakhulu - ngokomyalelo weepesenti ezimbalwa.
Ngaba i-Gluten iya kuba neengxaki kwi-Bipolar Disorder?
Kufuneka uphando olungakumbi ukuze kutholakale ukuba i-gluten idlala nayiphi na indima kwingxaki yokuguquguquka kwengqondo. Abaphandi ekufundeni kokuqala abajonga ngokuthe ngqo kwi-anti-gluten antibodies kubantu abanentsholongwane ye-bipolar baqaphele ukuba amanqanaba athile omzimba-kodwa awanabo bonke-aphakamileyo kakhulu kubantu abaneengxaki ze-bipolar.
"Kungenzeka ukuba abantu abaneengxaki ze-bipolar abaye bandisa iindiza zokulwa ne-gliadin babelana ngezidalwa ze-pathobiological zezifo eziphefumlelweyo, ezifana nokutyalwa okungavumelekanga kwamaprotheni okutya, ukufumanisa oku kuhambelana nokunyuka kwamanqanaba omzimba kwi-casin bovine Kwakhona kwafunyaniswa nengxaki yokuguquguquka kwengqondo kunye neengqondo zengqondo zamva kunye ne-schizophrenia, "abaphandi bathi kuhlalutyo lwabo. "Nangona kunjalo, indlela yokunyuka kwama-anti-gluten kwindlela yokunyuka kwe-anti-gluten inokuthi ihluke kwimiba yokuguquguquka kwe-bipolar ngokuthelekiswa nezifo ze-celiac."
Abaphandi baphetha ngokuthi: "Ngeli xesha, kuhleli ukuba i-protuten protein okanye i-response immune response to them have any role in the pathogenic mechanism of bipolar disorder or have the potential to serve as a biomarkers of diagnostic disease or activity." Iingcamango zexesha elizayo kufuneka zibandakanye i-gluten-free food in a bipolar disorder patients and anti-gluten antibodies eziphakamileyo.
Imithombo:
Dickerson F. et al. Iziganeko zobuninzi be-gluten kunye nesifo se-celiac kwisifo sengqondo se-bipolar. Iingxaki zeBipolar. 2011 Feb; 13 (1): 52-8. i-doi: 10.1111 / j.1399-5618.2011.00894.x.
Dickerson F. et al. Iimpawu zobuninzi be-gluten kwi-mania ebalulekileyo: Uvavanyo olude. Uphando loPhando. 2012 uMatshi 2. [Epub ngaphambi kokuprinta].
Ruggieri M. et al. Ubuninzi obubonakalayo beembonakalo ze-neurological and psychiatric kubantwana abane-gluten sensitivity. Journal of Pediatrics. 2008 Feb; 152 (2): 244-9. Epub 2007 Nov 19.