Ngokungafani nesifo se-celiac, ububele buka gluten abubonakali bufuna i-genetics eyiyo
Nangona uphando kwi-non-celiac novelity gluten luqala nje kunye nezifundo ezibonisa ukuba imeko ekhethiweyo ayizange iphindwe kwakhona, iziphumo zokuqala zibonisa ukuba akudingeki ukuba uthwale nenye yezinto ezibizwa ngokuba yizifo zengqondo ze-celiac ukwenzela ukuphuhlisa i-gluten novelwano.
Abo bafumana isifo esiqhekezayo , esona siqonde kakhulu kwiintlobo ezinhlanu ezahlukeneyo ze-gluten "zokungabikho komzimba," phantse zihlala ziphethe enye yezinto eziphilayo zodwa.
Enyanisweni, oogqirha bahlala besisebenzisa ukuhlolwa kwemizimba ukulawula isifo se-celiac - ukuba awunayo i-gene efunekayo ukuphuhlisa i-celiac, bathi, ngokuqinisekileyo aninayo imeko.
I-genetics ye-non-celiac ye-gluten uzwela ayicacile ngakumbi.
Indlela i-Genetics idlala ngayo kwi-Celiac Disease
"Izifo zengqondo zeliliac" zivela malunga nama-35 ukuya kuma-40% ebantwini bonke, kwaye ukuba unayo iigeni akuthethi ukuba uya kuba neengxaki ze-celiac - ithetha nje ukuba unako ukuvelisa izakhi zofuzo.
Izaziso ezithatha isifo kwisifo se-celiac ziyaziwa njengezityalo ze-HLA-DQ, kwaye ziyafumaneka kwiinkalo ze-HLA-class II zeDNA yethu. Wonke umntu ufumana ikopi enye yegciwane le-HLA-DQ kumama wabo kunye nekopi yesibili yegciwane le-HLA-DQ evela kubaba.
Kukho ezine iindidi eziqhelekileyo zemizimba ye-HLA-DQ, eyaziwa njenge-HLA-DQ1, HLA-DQ2 , HLA-DQ3 kunye ne-HLA-DQ4. I-HLA-DQ1 iphinde iphulwe phantsi kwi-HLA-DQ5 kunye ne-HLA-DQ6, ngoxa i-HLA-DQ3 iphinde iphulwe phantsi kwi- HLA-DQ7 , i- HLA-DQ8 kunye ne-HLA-DQ9.
Ekubeni wonke umntu ufumana iimbumba ezimbini ze-HLA-DQ (enye evela kumama kunye nomnye ovela kubawo), umntu unokufumana nayiphi na ininzi, ininzi yokudibanisa. Ezinye zalezi zakhi zegesi zibeka phambili kwisifo se-celiac, ngoxa uphando oluphambili luchaza ezinye iigleji ezinokukubeka phambili ekuvezeni ubuninzi be-gluten.
Siyazi ukuba uninzi lwabantu abanezifo ze-celiac ezibonakaliswa yi-biopsy zithwala i-HLA-DQ2 okanye i-HLA-DQ8 (i-subset ye-HLA-DQ3). Nangona kunjalo, ukususela malunga nama-35% okanye i-40% yabemi ithatha enye okanye zombini kwezi zifo zengqondo ze-celiac, ukuba izakhi zofuzo azithethi ukuba uya kufumana i-celiac - zikhona ezinye (ezingabonakaliyo) izinto ezibandakanyekayo.
Iimvelaphi ezibandakanyekayo kwi-Gluten Sensitivity
Xa kuziwa kwintlupheko ye-gluten, kubonakala ukuba izifo zesifo se-ecliac asinakudlala, ngokutsho kophando lokuqala.
Kwi- gluten yocwaningo lophando olukhishwe ngasekuqaleni kuka-2011 yi-University of Maryland uMcwaningi u-Alessio Fasano, abalobi bahlalutya iigleji zalabo bafumene unobulunga obuthathekayo, bawafanisa namanye amaqela abantu ababenokuthiwa "ngegolide isifo "esiqhelekileyo sokuxilongwa ngegazi kunye ne-biopsy.
Abaphandi bafumanisa ukuba kuphela ama-56% abo afunyaniswa ngokuba yi-gluten sensitive ne-DQ2 okanye i-DQ8, ebonisa ukuba ezo zengqondo azibandakanyekanga kakhulu ekuphuhliseni ukuveliseka kwe-gluten kunokuba ziphuhlise izifo ze-celiac. Nangona kunjalo, i-gene ebonakala ibonakala ngokuphindaphindiweyo kulabo abane-gluten uzwela kunabo bonke abantu, ngoko mhlawumbi banokudlala indima ethile kwi-gluten-senitivity - akucaci ukuba yintoni indima abangayidlala nayo.
Enyanisweni, oogqirha abaninzi bafuna ukubona ukufunyanwa kukaDkt. Fasano kuphindwe ngaphambi kokuba bavume ukuba uvelwano lwe-gluten lukhoyo. UDkt. Fasano ngoku usebenza ukuchonga ama-biomarkers angakhokelela ekuvavanyeni kobuzwe be-gluten .
Ezinye iziGenesis zibandakanyeka kwi-Gluten Inxoliseko
UDkt Kenneth Fine, owakhula inkqubo yokuvavanya u - EnteroLab gulen senzwa , ukholelwa ukuba wonke umntu oneengqungquthela ze-HLA-DQ2 kunye ne-HLA-DQ8 "uya kuzisa i-gluten kwisistim somzimba sokuzivikela-oko kukuthi, i-gluten evelele."
Kodwa abo abane-HLA-DQ2 kunye ne-HLA-DQ8 abodwa bodwa kwiveliti yabo yokutya, uDkt Fine uthi.
Ukholelwa ukuba wonke umntu ophethe i-HLA-DQ1 kunye ne-HLA-DQ3 nayo isetyenziselwe ukuba ne-gluten senzwa. Oko kuthetha ukuba abantu kuphela abaneikopi ezimbini ze-HLA-DQ4 (ngaphantsi kwe-1% yabemi base-US) abaxhomekeke ekuveleni kobubele be gluten, ngokutsho kukaDkt. Fine. Ngokwakhe uluvo, bonke abanye banokukwazi ukuvelisa imeko.
Abantu abaneikopi ezimbini zeejethi ezithile, ezifana ne-HLA-DQ7 (ifom ye-HLA-DQ3 efana ne-HLA-DQ8), ingozi enamandla kakhulu kwi-gluten, njengokuba abantu abaneikopi ezimbini ze-HLA-DQ2 bangahlakulela kakhulu isifo, uthi.
Khumbula, uphando lukaDkt Fine aluzange luchazwe ngabanye abafunda i-genetics ye-celiac ne-gluten uzwela, ngoko akucaci ukuba kuya kuqinisekiswa okanye cha. Nangona kunjalo, ukuba iziprofeto zakhe ziya kuba zichanekile, oko kuthetha ukuba phantse wonke umntu wase-US unezinye izakhi zofuzo ezisisiseko ezifunekayo ukuphuhlisa ubuzwe be-gluten. Nangona kunjalo, ekubeni kungekhona wonke umntu unayo imeko (jonga kwinqaku lam Uninzi lwabantu abane-Gluten Sensitivity? ), Kufuneka kubekho nezinye izinto kunye nezakhi zofuzo ezibandakanyekayo.
Ngaphantsi
Abanye abaphandi bafuna ukuba baqinisekise ezi ziphumo zokuqala kunye neengcamango zabo ukuba zamukelwe ngokubanzi kwizonyango zoluntu, kwaye kuninzi ukungazithembi phakathi kwamagqirha nokuba ubunjani be-gluten bukhona. Ngokusekelwe kulo lonke, ukuvavanya i-gene ye-gluten uzwela akunakwenzeka ukuba luncedo okanye luyenze kwihlabathi langempela ngeli xesha, ukuba likhona.
Sekunjalo, bobabini uDkt. Fasano noDkt Fine, phakathi kwabanye, baqhubeka befunda umba we-gluten sensitivity genetics. Uphando lwabo lubonisa ukuba nangona uvavanyo lwakho lwezakhi zofuzo lubi, usenokuba neengxaki nge gluten .
Imithombo
Ishicilelo se-EnteroLab: Iimbuzo ezibuzwa rhoqo malunga neZingcaciso.
A. Fasano et al. Ukutshatyalaliswa kwamathambo okubonakalayo kunye ne-mucosal gene gene expression) kwiimeko ezimbini ezinxulumene ne-gluten: isifo se-celiac kunye nobutyebi be-gluten. I-BMC Medicine 2011, 9:23.