Imfuza ye-HLA-DQ7 ayinakuthathwa njengenye yeengqungquthela eziphambili ezikwazi ukukubeka kwisifo se- celiac . Kodwa kukho ubungqina bokuba ingaba negalelo kwimeko, kwaye mhlawumbi kungabonakali kwintlupheko ye- gluten .
Isifo seCeliac sisimo esisekelwe kwizityalo, oku kuthetha ukuba kufuneka ube neelungelo "lokunene" ukuphuhlisa. Abaphandi baye bafumanisa ukuba iigciwane ze-HLA-DQ zibonakala zidlala indima ephambili kwi -atrophy ekhohlakeleyo- umonakalo owenziwe ngamathumbu emathunjini atholakala kwisifo se-celiac.
I-HLA-DQ iGenesis kunye neCeliac Disease
Zithwale mna: oku kuyanzima kwaye kudideka.
Wonke umntu uzuza iirayi ezimbini ze-HLA-DQ ezivela kubazali bazo-ufumana enye kumama wakho kunye noyihlo.
Kukho iintlobo ezahlukeneyo zegciwane le-HLA-DQ, kuquka i-HLA-DQ7, i- HLA-DQ2 , i- HLA-DQ8 , i-HLA-DQ9 kunye ne- HLA-DQ1 . Unokufumana iifayile ezimbini ezihlukeneyo ze-HLA-DQ (imeko eqhelekileyo), okanye i-dose ephindwe kabini yesinye i-HLA-DQ yegeni (imeko ephantsi kakhulu).
Kuzo zonke iindidi ezahlukeneyo zegciwane le-HLA-DQ, kukho ezimbini ezithiwa " izifo zesifo se-celiac :" i-HLA-DQ2 kunye ne-HLA-DQ8 encinane. Uninzi lwabantu abahlakulela isifo se-celiac bane-HLA-DQ2, ngelixa ipesenti ezincinci zinama-HLA-DQ8. Lezo zifo zombini zibonakala ziphendula malunga nama-96% omntu wonke ofumene isifo esiqhekezayo.
Indlela i-HLA-DQ7 ingena ngayo
Kukho abantu abangenayo i-HLA-DQ2 okanye i-HLA-DQ8 kwaye baqhubeka behlakulela isifo se-celiac.
Ubuncinane isifundo esithile sifumene ukuba malunga nesiqingatha sabantu (ngamanye amagama, malunga ne-2% yabantu bonke abanezifo eziqhekezayo) ngokwenene baphatha i-HLA-DQ7.
Oku kubonisa ukuba i-HLA-DQ7 ingaba ngumzimba onokubangela abanye abantu ukuba bafumane imeko.
Nangona kunjalo, le ngcamango ayizange ixhaswe kwezinye iifundo, kwaye kuphando olongezelelweyo lufunekayo ukufumanisa ukuba i-HLA-DQ7-efana ne-HLA-DQ8-ngokwenene ingakhokelela kwisifo se-celiac, nangona ungenayo enye zale "zifo eziphambili zezilwanyana zesifo." Ngeli xesha, abaninzi oogqirha abacinga ukuba i-HLA-DQ7 ibe yimizimba yesifo somzimba.
Kwakhona kunokwenzeka ukuba i-HLA-DQ7 idlala indima ethile kwi-non-celiac gulen senitivity, imeko ebhekwe njengeyohlukileyo kwisifo se-celiac (nangona iimpawu zentsholongwane ye-gluten ziphantse zifana neempawu zesifo se-celiac ).
UDkt Kenneth Fine, oye wavelisa ubuchule bokuhlola u- gluten obusetyenziswa kwi- Enterolab (inkonzo-ngqo kumthengi), uye waqokelela idatha yeGLA ye-HLA-DQ kwizigulane ezininzi zase-Enterolab. Uphelile, ngokusekelwe kuphando lwakhe olungashicilelwa, ukuba i-HLA-DQ7 ibeka phambili ukuba ube noveliso lwe-gluten. Nangona kunjalo, iyeza eliqhelekileyo lihlawula lophando kuba alizange lishicilelwe kwaye lugqitywe.
Kuqiniseke ukuba kukho ezininzi izakhi zofuzo ezibandakanyekayo ekuphuhlisweni kwesifo se-celiac, kodwa abaphandi abanakuzibona zonke. Uphando lwe-gluten sensitivity luqala nje, kwaye izazinzulu azizange zenze ukuba ingaba imeko yomeleleke ngokwemizimba.
Imithombo:
Sacchetti L. et al. Ulwahlulo phakathi kwamaCeliac kunye nezinye izifo eziMnandi zokuNyuka kweNtlungu ebantwini ngokuTyhulwa komzimba we-Anti-Lymphocyte Antigen Typing. Chemistry Clinic. Agasti 1998, Vol. 44, No. 8, iphe. 1755-1757.
IYunivesithi yaseMaldinburg Centre yeCeliac Research sheet. Izifo zeCeliac Ezibuzwayo Ngokubuzwayo.