I-Genetics inxulumene nomngcipheko wesifo esizimele
Isifo seCeliac sisifo esizimelayo ekudleni i-gluten kunokubangela iimpawu zesisu kunye nomonakalo emathunjini amancinci. Siyisifo esingaqondwanga ngokupheleleyo kodwa sibonakala sidibaniswe ngokuyinxalenye kwisifo somntu.
Siyazi oku kusuka kumbono obanzi ngaphandle kokuba umngcipheko wesifo se-celiac ukwandisa kakhulu ukuba isihlobo esithile sokuqala, njengomzali okanye umntakwabo, sinesi sifo.
Kwiminyaka yakutshanje, kunye nokuvela kovavanyo lwemizimba , izazinzulu ziye zakwazi ukuchonga ezimbini izakhi zofuzo ezibonakala ngokuqhelekileyo kubantu abanezifo ezinqabileyo. Baye kwiqela lezinto eziphilayo ezibizwa ngokuba yi-leukocyte antigen (HLA) yabantu kwaye zibandakanya:
- I-HLA-DQ2, ekhoyo malunga neepesenti ezingama-90 zabantu abanezifo ezinqabileyo
- I-HLA-DQ8, ebonwayo kwiingingqi ezisibhozo zabantu abafanayo
Nangona i-HLA-DQ8 ibonakala ibangela isizathu esincinci se-disorder, ityala ubuninzi beemeko ezingezizo ze-DQ2 kwaye zineminye impawu eyenza ibetha ngokukodwa.
Ukudibana phakathi kwe-HLA-DQ8 kunye neCeliac Disease
Kukho iintlobo ezahlukeneyo (i-serotype) zegalo ze-HLA-DQ apho iDQ2 kunye ne-DQ8 zimbini kuphela. Njengeqela, umsebenzi wabo oyintloko kukunceda umzimba uqaphele amanxeba angase abe yingozi, ukuvumela ukuba isistim somzimba sijolise kuloo maseli ukuba angathathi nto.
Ngamnye wethu unakho iikopi ezimbini ze-HLA-DQ yesitotype, enye esiyizuze kumama kunye nenye esiyifumana kubaba.
Ukuba umntu uzuza ilifa elifanayo le-HLA-DQ kubazali bakhe, kuthiwa u-homozygous. Ukuba umntu uzuze iintlobo ezimbini ezahlukeneyo, oku kuthiwa yi-heterozygous.
Njenge-serotype eyingqayizivele, i-HLA-DQ8 ixhaphake ngokuqhelekileyo kwizifo ezizimeleyo eziquka isifo se-celiac, i- rheumatoid arthritis , kunye nesifo sikashukela sesantwazana .
Ngenxa yezizathu ezingaziwa, lo mzimba ungawukhusela umzimba, uqondise isistim somzimba sokuhlasela nokutshabalalisa iiseli zayo.
Ngokubhekiselele kwisifo se-celiac, uphando luye lwaphakamisa ukuba i-HLA-DQ8 i-homozygous yandisa umngcipheko we-10 xa kuthelekiswa noluntu jikelele. Nangona ikopi enye HLA-DQ8, umngcipheko wakho ngaphezu kokuphindwe kabini.
Nangona kunjalo, i-heterozygosity ayisoloko isho umngcipheko omncinci. Ukuba udibanisa i-HLA-DQ8 ngenguqu ephezulu ye-HLA-DQ2, ubukho bakho bokugula buya kumaxesha angama-14 ewonke jikelele.
Indlela i-DQ8 eyahlukileyo ngayo kwiNgingqi
Inqaku elithi HLA-DQ8 lingahluka ngokubanzi ukusuka kwelinye inxalenye yehlabathi ukuya kwilandelayo. EYurophu, umzekelo, sisona sifo sinxulumene nesifo se-diabetes. Ngokufanayo, eJapan, apho oku kungenaye i-HLA-DQ2, i-serotype ye-DQ8 yimbangela yodwa yesifo se-celiac (eqinisiweyo, ngokukodwa, ngokunyuka kwe-gluten ekudleni kwaseJapan).
Ngokuthelekiswa, i-HLA-DQ8 ibonisa isahlulo esincinane sezifo ze-celiac kwi-US kwaye ixhaphake ngokuqhelekileyo ne-rheumatoid arthritis. Akunjalo loo nto ibaluleke ngokubhekiselele kwisifo sokuqhubela phambili. Kuza kubekho, akukho cetyiswa ukuba i-serotype inefuthe kwi-severe disease.
Ngaloo ndlela, mhlawumbi ezinye izinto zidlala indima ekubangela ukuba abanye abantu bafumane isifo esibi kunabanye.
> Umthombo:
> Tjon, J .; van Bergen, J; kunye neConing, F. "Isifo seCeliac: njani kunzima ukufumana?" Immunogenetics . 2010; 62 (10): 641-651. INGXELO: 10.1007 / s00251-010-0465-9.