Isifo seCeliac sisimo semfuza, oku kuthetha ukuba kufuneka ukuba ube neelungelo "lokunene" ukuphuhlisa kwaye ufumaneke. I-HLA-DQ2 yenye yezona zimbini zesifo se-ecliac eziphambili, kwaye zenzeke ukuba yinto edlalelekileyo yimizimba echaphazelekayo kwisifo se-celiac (i-HLA-DQ8 enye enye ebizwa ngokuba "i-gene eliyiyo").
Uninzi ogqirha bakholelwa ukuba ufuna enye ikopi enye ye-HLA-DQ2 okanye i-HLA-DQ8 ukuphuhlisa isifo se-celiac.
I-Celiac Genetics Basics
I-Genetics ingaba yinto yokudideka, kwaye i-genetics yezifo ze-celiac idideka ngokukodwa. Nantsi ingcaciso elula.
Wonke umntu unamajeni e-HLA-DQ. Enyanisweni, wonke umntu uzuza iikopi ezimbini zegciwane le-HLA-DQ - enye evela kumama wayo kunye noyise. Zininzi iintlobo ezahlukeneyo zegciwane le-HLA-DQ, kuquka i-HLA-DQ2, i- HLA-DQ8 , i- HLA-DQ7 , i-HLA-DQ9 kunye ne- HLA-DQ1 .
Yiyo i-HLA-DQ2 kunye ne-HLA-DQ8 yeentlobo ezahlukeneyo eziphakamisa umngcipheko wokuba nesifo se-celiac.
Ekubeni wonke umntu uzuza iirayi ezimbini ze-HLA-DQ (omnye kumzali ngamnye), Kunokwenzeka ukuba umntu abe nekopi enye ye-HLA-DQ2 (edlalwa njengeHLA-DQ2 heterozygous), iikopi ezimbini ze-HLA-DQ2 (HLA-DQ2 homozygous) , okanye akukho ikopi ye-HLA-DQ2 (HLA-DQ2 negative).
Ukongezelela, kukho ubuncinane iinguqu ezintathu ze-HLA-DQ2. Omnye, owaziwa ngokuthi yi-HLA-DQ2.5, unika umngcipheko omkhulu kwisifo esiqhekezayo; malunga nama-13% abantu baseCaucasian base-US bathwala lo mfuzo.
Nangona kunjalo, abantu abanezinye iinguqu ze-HLA-DQ2 nabo basengozini yokugula kwezifo.
Ukuba ndinayo iGene, yintoni Ingozi yam?
Ku xho mekeke.
Abantu abaneikopi ezimbini ze-HLA-DQ2 (ipesenti encinci yabemi) banomngcipheko ophezulu kunayo yonke yesifo se-celiac. Ngokweengqikelelo zomngcipheko oluthile olusekelwe kuphando olushicilelwe olwenziwe ngumsebenzi wokuvavanya i-MyCeliacID, isifo se-celiac senziwa kubantu abaneikopi ezimbini ze-DQ2 kwisantya malunga namaxesha angama-31 ewonke jikelele.
Abantu abaneikopi ezimbini ze-HLA-DQ2 nabo banomngcipheko okwandisiweyo ubuncinane bodwa uhlobo lwesifo esiqhekezayo se-celiac (esenzeka xa ukutya okungafaniyo kwe-gluten kubonakala kungasebenzi ukulawula imeko), kunye ne -T -ngenisa i-lymphoma , uhlobo lomhlaza oluthatyathwa nezifo ezinqabileyo.
Abantu abanephepha elilodwa kuphela le-HLA-DQ2 banamaxesha angama-10 "ubuninzi bemihlali" yesifo se-celiac, ngokutsho kwe-MyCeliacID. Abo baphatha i-HLA-DQ2 kunye ne-HLA-DQ8, esinye isifo se-gene eliyi-celiac, banamaxesha angama-14 "abantu abaqhelekileyo" engozini.
Ezinye izinto zibandakanya
Akubona wonke umntu ophethe i-HLA-DQ2 eyenza isifo se-celiac - i-gene ikhona ngaphezu kwama-30% wabantu base-US (ngokukodwa abo bahlala kumntla we-European genetic heritage), kodwa i-1% kuphela yama-Amerika ayinayo isifo se-celiac.
Abaphandi bakholelwa ukuba kunezinye izakhi zofuzo ezibandakanyekayo ekuqaliseni ukuba umntu ozaliswa ngumzimba wenzelwa ukuba akhuphe imeko, kodwa ayikaqapheli zonke iizakhi ezibandakanyekayo.
Imithombo:
Al-Toma A. et al. I-Leukocyte i-Antigen-DQ2 i-Homozygosity kunye noPhuhliso lweeNkcazo zeCaac kunye ne-Enteropathy-ehlangene ne-T-Cell Lymphoma. I-Clinical Gastroenterology kunye neHepatology. 2006 Mar; 4 (3): 315-9.
Itheyibhile yoLungiso lwe-MyCeliacID. Ufikelele kuMatshi 20, 2012.
Ploski R. et al. Kwi-HLA-DQ (i-alf 1 * 0501, inkolelo ye-beta 1 * 0201) -kuhlanganiswa okuhlanganisiweyo kwisifo se-celiac: umphumo we-gene we-DQB1 * 0201. Ama-Antigens amaTissue. Ngo-1993 kuMatshi; 41 (4): 173-7.
Vader W. et al. I-dose ye-HLA-DQ2 yesifo somdlavuza kwisifo se-celiac ihambelana ngokuthe ngqo kunye nobubanzi nobubanzi beempendulo ze-T ze-gluten. Iinkqubo ze-National Academy of Sciences. 2003 Oktobha 14; 100 (21): 12390-12395.