Qinisekisa Ingozi Yakho Yokuphuhlisa Izifo ZamaCeliac
Isifo seCeliac sidibaniswa nokuzalwa, oku kuthetha ukuba kuphela unokuhlakulela i-celiac ukuba uthwala iizakhi ezithintelayo kuwe. Ngako oko, oogqirha baqhubeka bezama ukusebenzisa izilingo zesifo se-ecliac ukuze baqaphele ukuba umntu unemfuneko yokuphuhlisa imeko.
Phantse wonke umntu udla i-gluten, iprotheni efunyenwe ngqolowa, ibhalley kunye nerye.
Nangona kunjalo, kubantu abanegciwane elifanelekileyo, ukungcola kwe-gluten ekugqibeleni kukukhokelela kwisifo se-celiac, imeko eyimimandla eyenza isifo sakho-ukulwa neeseli zegazi ezimhlophe zihlasele umbane wesisu sakho esincinci.
Akunjalo wonke umntu ophethe izifo zesifo se-ecliac ekugqibeleni uya kuhlakulela isifo se-celiac-enyanisweni, ngelixa i-40% yabemi inomnye okanye zombini iigesi ezifunekayo, kuphela i-1% yabemi ngokwenene inezifo ezingenazo. Ngoko ukuba ukukwazi ukuvelisa i-genetic does not mean you will be diagnosed with pesticides and need to give gluten; Enyanisweni, iingxaki zixhomekeke kuyo.
Nangona kunjalo, ukuvavanya izifo zesifo se-celiac kunokunika esinye isiqendu kwi-puzzle ye-diagnostic, ngokukodwa kwiimeko apho ukuxilongwa kwakho kungabonakali kakuhle okanye apho uzama ukunquma iimfuno zokuvavanya kwixesha elizayo.
Izifo zeCeliac Testing Genetic Testing Ikhangele iIjimesi ezimbini
Zithwale-oku kuyanzima.
Izaziso ezithatha ngaphambili kwisifo se-celiac zifumaneka kwi-HNA-class II complex of DNA yethu, kwaye ziyaziwa njengezityalo ze-DQ.
Wonke umntu uneekopi ezimbini ze-DQ-enye evela kumama wayo kunye noyise. Kukho iintlobo ezininzi zeengqungquthela ze-DQ, kodwa kukho ezimbini ezibandakanyekayo kwininzi yezifo ze-celiac izifo: HLA-DQ2 kunye ne- HLA-DQ8 .
Kule ndawo, i-HLA-DQ2 yinto eqhelekileyo kunabantu bonke, ngakumbi phakathi kwabantu abanamagugu aseYurophu-athile ama-30% okanye ngaphezulu abantu abakhokho babo abakhutshwa kwilo lizwe bathwala i-HLA-DQ2.
I-HLA-DQ8 ithathwa njengeyinqabileyo, ivela kwi-10% yabantu bonke, nangona ixhaphake kakhulu kubantu abavela eMbindi naseMzantsi Melika.
Ucwaningo luye lwabonisa ukuba malunga nama-96% abantu abaxilongwa yi-biopsy kunye nezifo ezingenazo i-DQ2, i-DQ8 okanye ukudibanisa ezimbini. Ekubeni ufumana i-DQ yegeni esisuka kumama wakho kunye nenye evela koyihlo, kunokwenzeka ukuba ube neikopi ezimbini ze-DQ2, ikopi ezimbini ze-DQ8, ikopi enye ye-DQ2 kunye ne-DQ8, okanye ikopi enye ye-DQ2 okanye i-DQ8 edibene enye i-DQ gene.
Nasiphi na isiganeko, ukuba uthetha enye ikopi ye-DQ2 okanye i-DQ8, uthathwa njengomngcipheko ophezulu kakhulu weengxaki ze-celiac. Kukho ubungqina bokuthi ukuthwala iikopi ezimbini zeejeni (okanye i-DQ2 okanye i-DQ8) kunokunyusa ingozi yakho nangakumbi.
Ubuncinane isifundo esisodwa sibonise ukuba enye i-gene ethize , i- HLA-DQ7 , ibuye ibonelele abantu kwisifo se-celiac. Enyanisweni, kweso sifundo, i-2% yabantu abane-biopsy-proven disease celiac iqhube i-HLA-DQ7, kodwa ayiyi-DQ2 okanye i-DQ8. Nangona kunjalo, kukho ukungqubuzana nokuba ngaba i-DQ7 imele ibeka phambili kwisifo se-celiac, kwaye ukuhlolwa kofuzo e-US okwangoku akuyikuboni i-DQ7 "njengesifo somzimba."
Ukongeza, uphando olutsha lubonisa ukuba akudingeki ukuba uphathe i-HLA-DQ2 okanye i-HLA-DQ8 ukwenzela ukuphuhlisa ubuzwe obungenalo celiac gulen .
Kukho iindidi ze-HLA-DQ ezongezelelweyo ezibandakanyeka kwi-gluten sensitivity; funda ngokubanzi Ngaba ufuna iizakhi ezithile zegeni ukuphuhlisa ubuzwe be-gluten?
Uvavanyo lweGeneli lweCeliac lubandakanya isikrini esilula
Ukuvavanya izifo zesifo se-ecliac akuyiyo intsha. Uza kunika ibhubhoratri kunye nesampuli yegazi lakho, sebenzisa i-swab ukuqokelela ezimbalwa zeeseli eziphuma ngaphakathi kwesitye sakho, okanye usebenzise i-syringe okanye i-vial ukuze uqoke amanye amathe. Igazi lakho, iitama zeetekisi okanye u-saliva ke zihlaziywa yibhubhoratri; naziphi na ezi ndlela zivelisa iziphumo ezichanileyo.
Uninzi lwabantu lunokuhlolwa kofuzo olwenziwa ngokubambisana nezinye izilingo eziyalelwe ngugqirha wazo.
Nangona kunjalo, kunokwenzeka (nangona kubiza) ukufumana uvavanyo ngaphandle kokuba ugqirha ubandakanyeka.
Kukho indawo ezimbini onokuzenza uvavanyo oluqhutywe ngaphandle komyalelo wogqirha: i-Enterolab, i-laboratory ekhethekileyo e-Dallas (i- Enterolab iphinda yenza uvavanyo lwentlupheko ye-gluten ), kunye neenkonzo zokuvavanya i-genetic 23andMe.com.
Ngeenxa ye-$ 150 (ehlawulwa ngexesha obeka ngayo umyalelo), i-Enterolab iya kuhlalutya izakhi zakho zegeni kwaye ikuxelele ukuba yiziphi iigazi ze-HLA-DQ ozithwalayo, kuquka nokuba uthwala enye yezona zibini eziphambili zegciwane lesifo. Uvavanyo luqhutyelwa ngeeseli eziqokelelwe nge-swab ngaphakathi kwidama lakho, ngoko akukho mali ehambayo. Emva kokuba udibanise itekisi lakho kwaye uthumele isampuli sakho, iziphumo zithunyelwe nge-imeyli kuwe malunga neveki ezintathu.
Nge-23andMe.com, okwangoku, uya kumkhahlela kwi-vial uze uthumele i-vial ukuze ihlolwe. Inkampani inikeza i-celiac izifo zovavanyo lwezityalo nge-"Health and Ancestry" yokukhetha, ebiza i-$ 200. Ingxelo yakho iya kunika ulwazi olunzulu malunga nookhokho bakho, kunye neenkcukacha ngezilwane zezofuzo.
Ukuvavanya kwe-Genetic akufanelanga ukuchonga
Ekubeni kungekhona wonke umntu ophethe i-celiac gene winds ekufumaneni ukuba unesifo se-celiac (abantu abaninzi abayifumananga nemeko nangomdla, ngokwenene), ukuhlolwa kofuzo olungenakulingana nokuxilongwa. (Jonga: Ndivavanywe kakuhle kwi-test ye-gene ye-celiac. Ngaba ndifanele ndihambe ngaphandle kwe-gluten? )
Yonke imvavanyo yakho yesifo se-ecliac yokuhlola i-genetic test ibeka wena kwiiyiphi iidokotela ezibhekiselele kwiqela "elibi kakhulu" leengxaki zeliliac. Ngoko ke, izivivinyo zemizimba yesifo sofuzo zixhamla kakhulu ukulawula isifo se- celiac kwiimeko apho kukho izibonakaliso ezingapheliyo. Kwezinye iimeko, umntu unokufumana iziphumo zokuvavanya okungapheliyo, kunye nokuhlolwa kwemizimba kunokunceda ugqirha ukuba ahlolwe kakuhle.
Iimvavanyo ze-Gene nazo zinceda ukulawula isifo se-celiac kwiintsapho zentsapho ze-celiacs ezixilongwe. Ukuvavanywa kwezifo ze-Celiac zezihlobo zinconywa xa omnye umntu osapho lwakho ufunyaniswa, kodwa ukuba uyazi ukuba uyithwala isifo somzimba we-celiac, kufuneka ulandelwe ngakumbi.
Ekugqibeleni, kunokwenzeka ukusebenzisa iimvavanyo zemizimba ukuze ubone ukuba isifo se-celiac sinokwenzeka kumntu osele esidla ukutya okungahambisani ne-gluten .
Kufuneka udle i-gluten yokuvavanya isifo se-celiac ukuze uchaneke. Nangona kunjalo, abanye abantu bayaqaphela ukuba ukutya i-gluten-free kwenza ukuba bazive bebhetele, kwaye basuse iprotheni ye-gluten kwizidlo zabo ngaphambi kokuvavanya isifo se-celiac. Ukuba kamva baya kuthatha isigqibo sokuba bafuna ukuxilongwa, banokhetho olubini: uzame umngeni we- gluten , okanye uzame ukuhlolwa kofuzo.
Awudingi ukutya i-gluten yesifo sesifo se-gyliac yesifo-kwakhona, uvavanyo luphela kuphela ukuba unako ukuhlakulela isifo se-celiac, kungekhona ukuba unayo. Ngoko ke, nangona uvavanyo lwemizimba alukwazi ukunika iimpendulo ezipheleleyo malunga nokuba unayo isifo se-celiac, abantu abaninzi bawukhetha kumngeni we-gluten kuba awufuni ukuba babuyele kwi-gluten ukuze bafumane ulwazi oluthe xaxa malunga nemeko yabo.
Kukho okuninzi esingayazi malunga nesifo se-celiac, kwaye akucaci isizathu sokuba abanye abantu abanezifo zesifo se-ecliac bakhule xa abanye bengenalo. Nangona kunjalo, ukuhlolwa kweempawu zesifo somzimba kungasiza ekufumaneni umngcipheko wemeko kumalungu entsapho, kunye nakwiimeko ezingacaciswanga ngokupheleleyo.
Imithombo:
Isiko seSifo seCeliac kwi-University of Columbia. I-Serologic kunye noVavanyo lweGenesis. Kufumaneka ngoJan 5, 2012.
AmaZiko eZiko lezeMpilo. INgqungquthela yoPhuhliso lwentsebenziswano ye-NIH kwiSifo seCeliac. Kufumaneka ngoJan 5, 2012.
Sacchetti L. et al. Ulwahlulo phakathi kwamaCeliac kunye nezinye izifo eziMnandi zokuNyuka kweNtlungu ebantwini ngokuTyhulwa komzimba we-Anti-Lymphocyte Antigen Typing. Chemistry Clinic. Agasti 1998, Vol. 44, No. 8, iphe. 1755-1757.
IYunivesithi yaseCichiac Celiac Disease Centre. Uvavanyo lweGenesis . Kufumaneka ngoJan. 5, 2012.