Ukungena-gluten-free kungabikho nto
Xa kufika ukuhlolwa kobugcisa be-molecular advanced, oogqirha ngoku banakho ukukwazi ukuchonga izifo zengxube okanye ukuxhomekeka ngqo kwisifo. Enye yalezi zifo zecalaac .
Ngokungafani nezinye iimeko apho umphumo ochaphazelekayo uhambelana ngqo neempawu zesifo, umphumo omuhle wokuvavanyelwa kofuzo lwe-gene uveza ubungako-kunokuba kuqinisekiswe-ngesifo.
Kwiimeko ezininzi, ubunzima buya kuba buncinci.
Ukuchonga iGenesis
Iinguqu ezimbini ze-chromosomal, ezaziwa ngokuba yi- HLA-DQ2 kunye ne- HLA-DQ8 , ziqhelekile zidibene nesifo se-celiac.
Ngenkcazo, i-HLA (i-leukocyte antigen yomntu) yiprotheni yamaselula eyenza i-response immune response. Ngesi sifo esiqhoqhoqho, ukubola kwe-HLA kubhalisa kungenza i-immune system ihambe haywire phambi kwe-gluten kunye nokuhlaselwa kwamaseli emathumbu amancinci .
Nangona i-HLA-DQ2 kunye ne-HLA-DQ8 zidibaniswe kunye nale mpawu, ukuba ukuguqulwa komzimba akuthethi ukuba uya kufumana isifo. Enyanisweni, amaninzi engama-40 ekhulwini labantu base-US banalo utshintsho, ikakhulu kubantu baseYurophu.
Kulabo bathatha ukuguqulwa komzimba, kuphela iipesenti enye kwipesenti ziya kuqhubeka nokuphuhlisa isifo kwiminyaka yabo emdala. Yonke into echazwe, malunga neyonke yabantu abayi-100 e-US iya kufumana isifo se-celiac ngesimo esinye okanye esinye sinempawu ezivela kwizinto ezinzulu ukuya ekungabikho .
Yintoni eyenzekayo xa Uvavanya kakuhle
Ukuvavanya kakuhle kwi-HLA-DQ2 okanye i-HLA-DQ8 akuthethi ukuba kufuneka utshintshe indlela yokutya ngaphandle kokuba unempawu zesifo (kubandakanya umonakalo kwi-villi ehamba emathunjini amancinci). Uvavanyo luza kukuxelela nje ukuba unesiphene sesifo, akukho nto.
Xa kuthethwa ukuba, iingcali ezininzi ziza kukucebisa wena kunye nosapho lwakho ukuba uhlolwe rhoqo kwimeko apho omnye okanye ngaphezulu wakho ekugqibeleni abe ngumqondiso.
Oku kungenxa yokuba ukuguquka kwe-HLA kudluliselwa kumzali ukuya kumntwana, kunye nabanye abantwana bezuza iikopi ezimbini zenguqu (omnye kumzali ngamnye) ngelixa abanye bebodwa kuphela. Ngokucacileyo, abo bazuze iimbini ezimbini basengozini enkulu.
Ngakolunye uhlangothi, ukuba unempawu kunye nazo zonke iziphumo zokuvavanya zibi, uvavanyo oluhle lwe-HLA lunokuthethelela ixesha lokuvavanya ngexesha oyeka u-gluten ukuze ubone ukuba iimpawu zakho ziphucula.
ILizwi
Abantu abakrokrela ukuba banesifo se-celiac baya kudla ngokuqala ukutya okungahambisani ne-gluten ukuze babone ukuba imeko yabo iphucula. Nangona oku kulungile kwaye akuyi kubangela naluphi na umonakalo, ukuqala kwangaphambili kunokuthintela amandla akho okufumana ukuxilongwa ngokuchanekileyo ukuba uthatha isigqibo sokwenza uvavanyo.
Oku kungenxa yokuba iphaneli yegazi eliqhelekileyo iya kubheka i-antibodies ekhethekileyo i-gluten egazini lakho, ngelixa uvavanyo lwe- endoscopic luza kufuna ubungqina obonakalayo bomonakalo emathunjini amancinci. Ngaphandle kokungena kwi-gluten, iimvavanyo azikwazi ukufumanisa iziganeko zesifo kwaye zingaphetha zibuyise umphumo ongalunganga .
Xa ufuna i-diagnostic echanekileyo, kufuneka ube ne-gluten. Uvavanyo lofuzo lunokubonisa nje ukuba unokugula kwesifo kunokuba unikeze ukuxilongwa ngokucacileyo.
> Umthombo:
> Wessels, M .; Vriezinga, S .; Koletzko, S. et al. "Impembelelo kubazali be-HLA-DQ2 / DQ8 yohlobo lwe-genotyping kubantwana abasempilweni ezivela kwiintsapho ezinqabileyo." Eur J Hum Genet. 2015; 23, 405-88. INGXELO: 10.1038 / ejhg.2014.113.