Ukuntula koLuntu kuBantu abane-IBD

I-folate yincithakalo yamanzi, i-vitamin eyinkimbinkimbi ebaluleke kakhulu emzimbeni kwimisebenzi embalwa kuquka ukudala iiseli ezintsha kunye nokwenza amangqamuzana egazi abomvu.

Kubizwa ngokuba ngumntu xa kufunyanwa ekudleni, njengemifuno, iziqhamo, kunye nemifuno eluhlaza. I-acid ye-folic iyinxalenye yokwenziwa komsebenzi efunyanwa kwiindawo ezininzi zokutya (ezifana nezonka kunye neesinkwa) kunye nokuncedisa.

Abantu abanezifo zesibindi sokuvuvukala (IBD) basengozini yokuntuleka komntu, ingakumbi abo bathatha i- methotrexate okanye i- sulfasalazine .

Kutheni i-Folate ibalulekile

Umzimba awukwazi ukwenza i-folate okanye i-folic acid, ngoko kufuneka ifumaneke ekudleni kunye nakongezelelweyo. I-folate yi-vitamin B ebalulekileyo ngaphambi nangesikhathi sokukhulelwa kuba isetyenziswe kwisilwanyana kunye nokwahlukana. Ukutya okwaneleyo kwenzelwe ukukhusela iimpazamo ze-neural tube ezifana ne- spina bifida kwintsana.

I-folate nayo iyafuneka ukuba umzimba ugcine amanqanaba afanelekileyo ye-amino acid homocysteine, efunekayo ngumzimba ngeprotheni synthesis. Ngaphandle kohlobo olwaneleyo, i-homocysteine ​​iya kwakha emzimbeni. Amanqanaba aphezulu ase-homocysteine ​​anxulumene nesifo senhliziyo.

I-folate inokukunceda ukunqanda umdlavuza ngokuthintela utshintsho oluthile kwi-DNA yomzimba. Kungenxa yokuba kubakho ukulandelelana okufunekayo ukwenza amangqamuzana egazi abomvu, ukufumana ubungqina obaneleyo kubalulekile ukukhusela i- anemia .

Kutheni izigulane ze-IBD zisengozini yokunqongophala kwamaFolda

Abantu abanesifo sikaCrohn kwi- intestine yabo encinci basengozini yokuxhatshazwa kwamanzi amavithamini kunye neemaminerali-ezibandakanyiweyo. I-Folate ibanjwe ngumgangatho ophakathi kunye nendawo yokugqibela yamathumbu amancinci, ijejunum kunye ne-ileum.

I-Sulfasalazine kunye ne-methotrexate yimiba emibini eyenziwa ukuphatha i-IBD engaphazamisa isifo se-metabolism.

Ezinye izizathu zokuxhatshazwa ngokungahambi kakuhle zibandakanya ukusetyenziswa kakubi kotywala, izifo zesibindi kunye nokusetyenziswa kwemithi ye-anticonvulsant, i- metformin , i-triamterene, okanye i-barbituates.

Ngaba Wonke umntu onobungozi be-IBD useMngciphekweni wokuLungeleka kweFolate?

Olunye uphando lubonise ukuba izigulane ezisandul 'ugqirha zentsholongwane zineziganeko eziphezulu eziphezulu kunabantwana abangenayo i-IBD. Ababhali bamangaliswa, ngenxa yokuba i-reverse ifunyanwe yinyani kubantu bakudala be-IBD. Amanqanaba e-Folate kubantwana abane-IBD angadinga ukuba alandelelwe ukuba aqinisekise ukuba iimfuno ezifunekayo ziyimfuneko.

Izigulane ze-IBD zisengozini yamanqanaba aphezulu e-homocysteine. I-Homocysteine ​​i-amino acid, kwaye amanqanaba aphakamileyo ahlanganiswe negazi kunye nokuhlaselwa kwentliziyo. Kubantu abane-IBD, ukungakwazi ukulandelelana okanye ukungahlawuliswa kwamalungu angama-homocysteine ​​ephakamileyo-ubungqina buphikisana. Ubuncinane uphando oluthile lubonise ukuba ukwanda kwe-homocysteine ​​kubantu abane-IBD kunokubangelwa ngamanqanaba aphantsi kwe-vitamin B12, kunokuba aphantsi kwamanqanaba e-folate.

Into onokuyenza

Ukuthintela ukungabikho komntu, kunokucetyiswa ukuba abantu abane-IBD bathathe isongezelelo se-folic acid. Abo bathatha i-sulfasalazine kunye ne-methotrexate, ngokukodwa, bangadinga i-folic acid. Ukuxhaswa kwe-aclic acid ye-1000 microgram (1 milligram) ngosuku kudla ngokucetyiswa kulabo basengozini yokulahleka komntu.

Hlola kunye nogqirha wakho ukuze unqume ukuba ungakanani u-acid we-folic oyifunayo imihla ngemihla nokuba ngaba ufuna ukuthatha naziphi na izongezo.

Ezinye ukutya ezinobumba okanye i-folic acid zi:

Imithombo:

Crohn's and Colitis Foundation of America. "Ukutya nokutya." CCFA.org 29 Apr 2009.

U-Erzin Y, u-Uzun H, u-Celik AF, u-Aydin S, u-Dirican A, u-Uunismail H. "I-Hyperhomocysteinemia kwizigulane zezifo ezikhukhulayo ngaphandle kokuthengiswa kwamathumbu emathunjini amandulo: ukudibanisa kunye ne-cobalamin, i-pyridoxine, i-folate concentrations, ama-reaction reactants, . " J Clin Gastroenterol 2008 Meyi-Juni; 42: 481-486.

Heyman MB, Garnett EA, uShaikh N, et al. "Izigulane zengqondo kwizigulana zezilwanyana ezinezifo zesifo esasandul 'ukutshaya." Am J Clin Nutr 2009 Feb; 89: 545-550.

Ofisi yeZibonelelo zeZidlo. "I-Supplementary Supplement Sheets: I-Folate." Iziko zeSizwe zezeMpilo 15 Matshi 2009.

I-Romagnuolo J, i-Fedorak RN, i-Dias VC, i-Bamforth F, i-Teltscher M. "I-Hyperhomocysteinemia kunye nesifo sesibindi sokutshatyalaliswa: isantya kunye nokuqikelela kwinqanaba lokufunda." U-J Gastroenterol 2001 Jul; 96: 2143-2149.

Silaste ML. "Iimpembelelo zetya kuma-antioxidants, i-LDL ene-oxidised kunye ne-homocysteine." I-yunivesithi yase-Oulu 2003.

UVagianos K, uBector S, uMcConnell J, uBernstein CN. "Ukuhlolwa kwesondlo kwezigulane ezinezifo zesifo." JPEN J Parenter Enteral Nutrition 2007 Jul-Aug; 31: 311-319.