Ukusetyenziswa, iimpembelelo ezingezantsi, isisombululo kunye nokusetyenziswa kweMethotrexate ekukhulelweni
Yintoni i-Methotrexate?
I-Methotrexate yile klasi yeziyobisi ezibizwa ngokuba yi-antineoplastics. I-Antineoplastics ikhupha inkqubo yendalo yeekhemikhali, njengeDNA yemveliso kunye nokwahlukana kweeseli. Ziluncedo ekunyilweni konyango, kuba ziya kuthintela iiseli zomhlaza ukuba ziphumelele. I-Methotrexate inganikwa kwakhona ukuphatha i-akylosing spondylitis, i-rheumatoid arthritis, i-psoriasis kunye nesifo sika-Crohn
I-Methotrexate ithathwa njani?
I-Methotrexate kufuneka ithathwe ngokuchanekileyo njengoko kuchazwe ngugqirha. Umzimba uya kulungelelanisa umlinganiselo kwiimfuno zesigulane ngasinye. I-Methotrexate inokunikezwa njenge-tablet, ukumnika okanye ukujova. Ukuba kuthathwa kanye ngeveki, kukulungele ukuthatha loo mini ngeveki.
Kutheni I-Methotrexate Ichazwe?
Ngenxa yokuba i-methotrexate ivimba i-cell metabolism, imiselwe imiqathango apho ukukhula kweeseli ezingaqhelekanga kuyinkathazo, njenge- psoriasis okanye umhlaza. I-Methotrexate ifunyenwe luncedo ekuphatheni iziganeko zesifo sikaCrohn kunye nesifo se- rheumatoid arthritis . I-Methotrexate isetyenziselwe ukukhupha isisu ngokukhulelwa kwe-ectopic.
Ngubani Akufanele athathe iMethotrexate?
Tshela ugqirha wakho ukuba unayo na le miqathango ilandelayo:
- Njengamanje ukhulelwe
- Izifo zesifo
- Isifo sesibindi okanye i-cirrhosis
- Isifo se-Lung okanye i-fibrosis
- Izifo ze-neurologic
- Izifo ezifayo
Ziziphi Iimpembelelo Zecala?
Imiphumo emibi ye-Bothersome ye-methotrexate iquka intloko, ukulala, ukubetheka, ukugqithisa isikhumba, ukuxakeka, kunye nokulahleka kweenwele.
Iziphumo ezibi kakhulu ziquka ukutyhefu kwesibindi, umongo wethambo okanye, ngokungafanekiyo, imiphunga. Bona iphepha leempembelelo ze - methotrexate kwiphepha elipheleleyo.
Ngaba kukho ukubandakanyeka kokutya?
Iziyobisi kufuneka zingasetyenziswanga ngelixa zithatha i-methotrexate, njengoko ingabangela umonakalo kwisibindi, ekhokelela kwi-cirrhosis.
Ziziphi Iimpawu Zamayeza Ongazenzayo?
Abantu bathatha i-methotrexate kufuneka baphephe ukugonywa ngegciwane eliphilayo. I-Methotrexate ibangela ukuba isistim somzimba sokuxhatshazwa kwe-immune sigxininiswe, ngoko ke ukugonya kwegciwane eliphilayo kungabangela ukuba ugula endaweni yokuphendula ngomzimba.
I-FDA ikhuthaza ukulumkela ekuthathe i-methotrexate kunye neproton pump inhibitor (PPI) , eziyingozi eziza kunciphisa inani le-asidi esiswini. Ezinye i-PPI eziqhelekileyo ziquka iProlosec ( omeprazole), i- Nexium (esomeprazole) , ne- Protonix (pantoprazole). Inkxalabo iboniswe ngokubanzi kulabo bathabatha amanani aphezulu e-methotrexate. Ingxaki kukuba i-PPIs inokunyusa amazinga e-serum (inani elitholakala egazini) le-methotrexate. Amanqanaba e-serum aphezulu angathetha ukuba kukho inani eliyingozi le-methotrexate ekwakheni umzimba. Imiphumo epheleleyo yale nxaxheba isacatshungulwa, kodwa ngoku i-FDA ikhiphe isilumkiso malunga nokuthatha i-methotrexate kunye ne-PPI.
I-Methotrexate inokusebenzisana namachiza alandelayo:
- Iziyobisi ze-arthritis (ibuprofen, Advil, Motrin, Naprosyn, Voltaren, iLodiine)
- I-Aspirin okanye enye i-salicylates
- Azathioprin (Imuran)
- I-bismuth subsalicylate (iPepto Bismol)
- ICarbenicillin (Geocillin)
- Cholestyramine (Questran)
- Abagcini begazi (iCoumadin)
- I-Cyclosporine (iSandimmune, Neoral)
- Digoxin (Lanoxin)
- I-Etretinate (Tegison)
- Phenytoin (Dilantin)
- Probenecid
- Iproton pump inhibitors (PPIs)
- Iidakamizwa zeSulfa (iBactrim)
- I-Thiazide diuretics (iDyazide, i-hydrochlorothiazide)
Ngaba i-Methotrexate ikhuselekile ngexesha lokukhulelwa?
I-FDA ifake i-methotrexate njengoluhlobo lwe-X. Oku kuthetha ukuba uphando kwizilwanyana okanye kwabasetyhini abakhulelweyo babonise ubungqina obunobungqina bokungabikho komntwana. I-Methotrexate ayifanele isetyenziswe ngexesha lokukhulelwa njengoko kunokubangela ukukhulelwa kwesisu okanye ukukhubazeka kokuzalwa embindi. Amadoda kufuneka aphelise i-methotrexate ubuncinane kwiinyanga ezintathu ngaphambi kokukhulelwa.
Abasetyhini kufuneka bayeke i-methotrexate ngomjikelezo owodwa ovulation ngaphambi kokukhulelwa. I-Methotrexate idlula ubisi lwebele, kwaye inokuchaphazela umntwana oswele. I-FDA icebisa ukuba i-methotrexate ingasetyenziselwa kubafazi beminyaka yobudala ngaphandle kokuba "kukho ubungqina bonyango obucacileyo ukuba inzuzo ingalindelwa ukuba ikhuphe ingozi."
Ixesha elide linokuthi i-Methotrexate ithathwe ngokukhuselekileyo?
I-Methotrexate ingathatha iiveki eziliqela ukuba iphumelele ekuphatheni isifo sikaCrohn. Kufuneka kuthathwe kuphela ixesha elide (inyanga okanye iminyaka) phantsi kolawulo olusondeleyo lugqirha.
Umthombo:
Hospira, Inc. "I- Methotrexate Injection, i-USP ." FDA.gov. Oktobha 2011.
Ulwazi lweMicrodex yeMicrosoft Information. "Methotrexate (ngomlomo)." Health PubMed. Dec 2015.