Izifo-Ukuguqula i-Anti-Rheumatic Drug yeArthritis
I-Sulfasalazine (igama elithi brand Azulfidine) liyilisi efumanekayo malunga neminyaka engama-60, kodwa ukusetyenziswa kwayo kwanda kuphela kwiminyaka emibini edluleyo. Kubonakala ngathi ulahlekelwa ukuthandwa njengamayeza e- biologic kuqala athengiswa ngo-1998 kwi- rheumatoid arthritis . Kubonakala ngathi yabuyisela izigulane ezingenako ukunyamezela i- methotrexate okanye abaviwa abangafanelekanga kwiziyobisi ze-biologic.
Iqela leziyobisi
I-Sulfasalazine, njengoko unokukrokrela egameni layo, ungowesigaba seziyobisi ezibizwa ngokuba yiziyobisi zesulfa. I-Sulfasalazine iqukethe i- salicylate kunye ne-sulfa antibiotic. I-Sulfasalazine iphinda ihlelwe njenge- DMARD (isifo sokuguqula isifo se-rheumatic drug).
Iimpawu zokusetyenziswa kweSulfasalazine
Ngaphandle kokusetyenziswa kwayo njengonyango lwe-arthritis ye-rheumatoid, i-sulfasalazine ikwalelwe ukuba i-arthritis yabantwana , i- psoriatic arthritis , i- spondylitis ene-ankylosing kunye ne-ulcerative colitis.
I-Sulfasalazine inceda ukunciphisa intlungu, ukuvuvukala, nokuqina okuhambisana ne-arthritis. Eyona ndlela iphumelele kakhulu ekuphatheni iimpawu ezincinci ukuya kwiimodareyitha. I-Sulfasalazine nayo inokuthintela umonakalo kunye kunye nokunciphisa umngcipheko wokusebenza ohlangeneyo. Ngokuqhelekileyo, izigulane ezithatha i-sulfasalazine ziyaqaphela ukuphuculwa kwiveki ezili-12.
Ulwazi loLungiso kunye nokuFumaneka
I-Sulfasalazine ifumaneka njengetyulethi ye-500 mg. Kunconywa ukuba uthathe ukutya kunye nokusela isilawuli samanzi xa utywala i-sulfasalazine.
Utyando lwe-rheumatoid arthritis luqala ngokuthe ngcembe. Kwiveki yokuqala, izigulana zithatha iipilisi ezine-sulfasalazine ngosuku. Iyakuthi yonyuka ibe ngamacwecwe amabini kabini ngosuku. I dose ephezulu iipilisi ezi-6 ngosuku. Iipilisi ezenziwe nge-Enteric ziyafumaneka kwaye zinokunceda ngesisu esicasulayo.
Iimiphumo eziqhelekileyo ezibandakanyeka ne-Sulasalazine
I-Sulfasalazine idibene neempembelelo eziqhelekileyo eziqhelekileyo.
Iziphumo eziqhelekileyo ezichaphazelekayo ziyisicefezelo okanye isisu esiswini. Imiba yesisu ibonakala isombulula ixesha, ingakumbi xa isilwanyana sinikezelwa kumthamo ophantsi ekuqaleni. Iziphumo eziqhelekileyo ezichaphazelekayo zingabandakanya ukugqithwa kwesikhumba, intloko yesifo, izilonda zomlomo, ukubetha, iingxaki zesenzo somlenze, kunye nokuzwela kwelanga.
Impendulo Eyingozi Ebonakalayo
Impendulo embi kakhulu enxulumene ne-sulfasalazine ibandakanya i-anorexia, intloko enzima, ukunyamezela kwesisu, ukuhlanza, kunye nesibalo se-sperm esiphantsi. Inani elincinci lomzimba lingahlaziywa ngokuyeka ukusetyenziswa kweziyobisi. Ezi mpembelelo ezingathandekiyo zichaphazela malunga nesithathu kwisigulane esiphathwe nge-sulfasalazine. Izimpembelelo ezingalunganga ezichaphazela ngaphezu kwe-1 kwezigulane ezingama-30 ezithatha i-sulfasalazine zibandakanya ukubetha, umquba, umkhuhlane, i-anemia yomzimba, i-hemolytic anemia, kunye ne-cyanosis (i-bleu discoloration).
Nangona ukuphendula okungathandekiyo kakubi kungabonwa njengento eqhelekileyo, bavame ukunyuka xa umthamo wansuku zonke we-sulfasalazine ulingana okanye udlula ama-4 amagremu. Kwakhona, kukho nezinye iimpendulo ezimbi ezinxulumene ne-sulfonamides (iidakamizwa ze-sulfa) ekufuneka ziqwalaselwe ukuba zinokwenzeka nge-sulfasalazine, kubandakanya ukuphazamiseka kwegazi, ukusabela kwe-hypersensitivity, ukuphendula kwe-system, kunye ne-urine kunye ne-skin coloring.
Ukuchasana (Ngubani Akufanele Athabise Imithi)
I-Sulfasalazine ayiyona indlela yokwelapha efanelekileyo kwizigulane ezinomkhuhlane okanye emcimbini, i- porphyria , okanye kwizigulane ezine-hypersensitivity eyaziwayo kwi-sulfasalazine, i-sulfonamides, okanye i-salicylates.
Izilumkiso kunye nokuqapha
Ukunciphisa umngcipheko weempembelelo okanye iimpendulo ezimbi. kufuneka uqaphele ezi zilumkiso kunye nezilumkiso xa uthatha i-sulfasalazine.
- Iimvavanyo zegazi rhoqo kufuneka ziqhutywe ukujonga ukubala kwegazi, umsebenzi wezintso, kunye nesibindi somsebenzi.
- Ukuba uceba ukukhulelwa, ukhuthazwa ukuba uxoxe ngokusetyenziswa kwe-sulfasalazine kunye nogqirha wakho. Abasetyhini abancancisayo akufanele bathathe i-sulfasalazine.
- I-supplementation ye-folic acid ingabalulekile ukuba uphathwa nge-sulfasalazine.
- Qaphela ukusebenzisana kweziyobisi kunye ne-sulfasalazine ukuba uthabathe i-Coumadin (warfarin), i-cyclosporine, okanye i-digoxin. Isilwanyana sinokunyusa umngcipheko wokulimala kwesibindi kwizigulane ezithatha i-isoniazid yesifo sofuba. I-Sulfasalazine inokunyusa umngcipheko we-ushukela ophantsi wegazi phakathi kwezigulane ezithatha imishanguzo yeswekile.
Imithombo:
Sulfasalazine (Azulfidine). Ikholeji yaseMerika yaseRheumatology. Matshi 2015.
http://www.rheumatology.org/I-Am-A/Patient-Caregiver/Treatments/Sulfasalazine-Azulfidine
I-Rheumatoid Arthritis: I-Early diagnosis and Treatment. I-Cush JJ MD, Weinblatt ME MD, iKavanaugh I-MD Professional Communications, Inc. Copyright 2010.