I-salicylates ichongwa njenge-NSAID
Ukuthetha ngokwemvelo, i-salicylates yile ityuwa okanye i-ester ye-salicylic acid. Ininzi yethu iyazi ukuba i- aspirin ivela kwi-salicylic acid. I-Aspirin isaziwa ngokwemichiza njenge-acetylsalicylic acid. Ama-Salicylates ahlukaniswe ngamaqela amabini, acetylated and nonacetylated. Nangona i-aspirin i-acetylated, imizekelo ye-salicylates engabandakanyiyo iquka i-disalcid (salsalate), i-Trilisate (i-choline magnesium trisalicylate), ne-Pepto-Bismol (i-bismuth subsalicylate).
Omnye, obizwa ngeDolobid (diflunisal), awusatholakali e-US.
Indlela uSalicyates Eyasetyenziswa ngayo
Ifunyanwe ngokwemvelo kwizityalo ezithile, ezifana ne-white willow bark kunye namaqabunga e-wintergreen, i-salicylates yayikholelwa ukuba inefuthe lokukhusela kwiinambuzane kunye nezifo zityalo. Ngomnyaka we-1860, i-salicylic acid yayinokwenziwa kwemichiza ekhokelela ekusebenziseni okubanzi. Ngokwemithi, i-salicylic acid ine-analgesic (intlungu-yokukhulula), izakhiwo ezichasayo nezikhuselekileyo. Kwaye, ngenxa yokuba kunokunciphisa intlungu kunye nokunciphisa ukuvuvukala kunye nomkhuhlane, i-salicylic acid ibonakala ngathi i-Trifecta yeyeza. Nangona kunjalo, kwiidayimenti ezifunekayo ukwenza loo mpendulo, i-salicylic acid ingabangela imiba yesisu. Ukuba kuthengwa ngamanani amakhulu, ngaphezu kwezinto ezibekwe umthelela wokwelapha, i-salicylic acid ingaba yingozi. Ukongezelela, abanye abantu banokuthi bahluthe i-acid e-salicylic. Ngaphandle kokusetyenziswa kwayo kwiyeza, i-salicylates isetyenziselwa ukulondoloza ukutya, kwi-antiseptics, kunye nezinye iipropati ezikunceda ukukhusela ukukhula kwebhaktheriya, ukubulala i-fungus, nokukhupha isikhumba esilufile (i-keratolytic, njengeKerasol).
Ingozi yesisu kunye neengozi ze-Cardiovascular Risk ezidibene namaSalicylates
Ngokungafani ne-aspirin, ekhubaza i-platelet aggregation kwaye ngenxa yoko yandisa umngcipheko wokuphuma kwamanzi, amaqumrhu angenakucetywayo anemiphumo engaphezulu kwiiplatelet. Ngenxa yoko, abanamathuba okubangela ukuba igazi okanye i- ulcers ephaphake kwiimilinganiselo ezifunekayo ukunciphisa ukuvuvukala kunye nentlungu ye-arthritis.
Ngakolunye uhlangothi, ubuncinane xa kuthelekiswa ne-aspirin ye-dose ephantsi, akukho zifundo zokuxhasa ukuba ii-salicylates ezingenakucetyiswa zi-cardioprotective. Enyanisweni, njengawo onke ama- NSAID (izidakamizwa ezichasene ne-anti-inflammatory drugs) , ukusetyenziswa kwazo kungabangela ubungozi obunzulu beemeko zesifo senhliziyo, ezifana nesifo senhliziyo.
Ngokwe-rheumatologist, uScott J. Zashin, MD, "Kungakhathaliseki ukuba i-aspirin i-high-dose ephezulu i-aspirin i-cardioprotective njenge-aspirin ephantsi. ze-salicylates ezingabandakanyiyo kunye ne- COX-2 inhibitors . "
Izifundo ezinokufunyanwa ngokubhekiselele kwi-salicylates zihlala zikhulile. Uphando olupapashwe kwi-Journal of Rheumatology luqhathanise ukuphumelela kwe-salalslate engabandakanyiyo kwi- Voltaren (i-diclofenac) . Kwakugqitywa ukuba i-diclofenac yasebenza kwaye i-diclofenac yayinokusebenza ngokulinganayo kwaye i-salsalate ingaqwalaselwa ngenye indlela kwezinye i-NSAID.
Olunye uphando, oluye lwapapashwa kwi-Journal of Rheumatology, luvavanya umphumo weminyaka kwi-salicylate inetyhefu kubantu asebekhulile abane- rheumatoid arthritis . Nangona kuthatha umthamo ophantsi we-salicylates kuneqela elincinci labantu ekufundweni, iqela elikhulile lidibaniswe nokunyuka kwetyhefu.
UDkt. Zashin waqhubeka wathi, "Ngokwamava am, i-NSAID yendabuko kunye ne-COX-2 inhibitors, ngokuqhelekileyo, i-agents esebenzayo ngakumbi ukuphatha intlungu kunye nokuvuvukala kwe-arthritis. kwizigulane ezikhethiweyo ezinomngcipheko wokukhupha okanye izilonda. "
ILizwi
Kwiminyaka emashumi edlulileyo, i-salicylic acid okanye i-aspirin yiyayisisigxina esisetyenziswayo ukulawula intlungu ye-arthritis. Okubonakala ngathi ukunciphisa ukuvutha kwaba ibhonasi ngelo xesha. Ngoku, kukho ezininzi iziyobisi eziza kukhetha. Ngokuqhelekileyo kucinga ukuba ikhuselekile, kunye nexabiso elingathethekiyo ngokuthelekisa nezinye iziyobisi, i-salticylates yinto ekhethekileyo ekufuneka iqwalaselwe oogqirha kunye nezigulane.
Kunengqiqo kuwe kunye nodokotela wakho ukuba uqwalasele imbali yakho yonyango (umzekelo, izilonda, isifo senhliziyo) xa ukhetha phakathi kwezikhetho zeziyobisi.
> Imithombo:
> IBombardier C. et al. I-Salsalate, i-Salicylate engabandakanyiyo, i-Efficacious njengeDiclofenac kwizigulane ezine-Arthritis ye-Rheumatoid. I-Salsalate-iDiclofenac Study Group. Journal of Rheumatology. Ngo-1995. Ngo-Apreli; 22 (4): 617-24.
> Grigor RR et al. I-Salicylate Inetyhefu kwizigulane ezithembekileyo ezine-Arthritis ye-Rheumatoid. Journal of Rheumatology 1987. Feb; 14 (1): 60-66.
> Salicylates. Drugs.com.