I-Pennsaid iyisisombululo se-NSAID esisisigxina esifumene nokuvunyelwa kwe-FDA ngoNovemba 4, 2009, ukunyanga iintlungu kunye neempawu ezihlobene ne- knee osteoarthritis . Igama lesi-generic le-Pennsaid li-diclofenac sodium. I-Pennsaid yaveliswa nguNovo Research Inc. Le nguqulelo ye-diclofenac, ikhona njengepilisi.
I-Pennsaid isebenza njani?
Zonke iziyobisi ezingekho-steroidal ezichasayo (i-NSAID) zisebenza ngendlela efanayo.
Zivimbela i-cyclooxygenase, i-enzyme ejongene nokuveliswa kwe-prostaglandines, eziyimfuneko yezithunywa zamakhemikhali kwi-cascade evuthayo. Ngokumvimbela ukuba i-enzyme, ii-NSAID zikhokelela ekunciphiseni amanqanaba e-prostaglandines kwaye ngoko-ke ukuvuvukala okuncinci. Ngelishwa, i-prostaglandin inomdla kwiminye imisebenzi yomzimba, ngoko ke ii-NSAID zinemiphumo emibi. Ngokuphawulekayo, i-prostaglandin yinto ephambili ekuveliseni i-membrane ye-mucous yesisu ebalulekileyo ekukhuseleni isisu esiswini kwi-asidi. Ii-NSAID, ngokunciphisa i-prostaglandin, ekhokelela ekudakaleni kwalo mngcipheko wokukhusela kwaye kunokukhokelela kwisisu nesilonda.
Iingcamango ezisemva kokusebenzisa i-NSAID yezobugcisa kukuba ukusetyenziswa kwendawo kweso siza kuholele ekunciphiseni ukuvuvukala, kunye nokuncipha okuhambelana nentlungu kwisayithi yesicelo, kodwa isilwanyana asiyi kufika kumaqondo aphezulu okwaneleyo okukhokelela kwimiphumo emibi yecandelo ezifana nezilonda zesisu.
Enyanisweni, uphando luye lwabonisa ukuba ngeendlela ezisemgangathweni ze-NSAID amanqanaba ohlelo lwesigqirha kuphela malunga ne-5% yezinto eziphakathi kwezicubu apho isilwanyana sisetyenzisiweyo.
Imiphumo emibi efana ne-NSAID yomlomo
Ukusetyenziswa kwee-NSAID zezobugcisa kwonyango lwe-knee osteoarthritis kunika izibonelelo ezinokubakho kwezikhuseleko ezininzi kwizigulane ezithile.
Inkqubo emva kwezi zibonelelo njengoko kuchaziwe ngasentla. Unyango lwangoku lukhuselekile kwaye lunokunyamezela xa lufaniswa ne-NSAID zomlomo.
Iimeko ezinobungozi ezinjengezilonda, ukuphuma kwegazi , kunye neengozi ze-cardiovascular zikhona kodwa ziphantsi ukuthelekiswa nefilisi yezobisi.
Umphumo oqhelekileyo ochaphazelekayo ohambelana nePennsaid ubumile obukrakra okanye ukucasula apho kusetyenziswa khona.
Ngaba isebenza?
Ukuhlaziywa kwakutshanje okwenziwa yi-Cochrane Collaboration kubhekisele kwizifundo ezingama-61 eziphanda ukuba ngaba ii-NSAID zengxelo zisebenza. Ngamafutshane, impendulo nguyebo. Xa udibanisa idatha kuzo zonke izifundo, malunga nama-75% abantu bafumana uxolo olukhulu lweentlungu zesistim / ezidibeneyo (intlupheko ebalulekileyo ichazwa ngokunciphisa intlungu ngesiqingatha) xa usebenzisa i-diclofenac ye-topical, oku kwahluke kumalunga nama-50% abantu fumana indawo.
Imithombo:
Ukuhlaziywa kweCchrane ye-Topical NSAIDs
> http://www.cochrane.org/CD007402/SYMPT_topical-non-steroidal-anti-inflammatory-drugs-for-acute-musculoskeletal-pain-in-adults
I-FDA iyavuma iP Pennsaid. Drugs.com.
http://www.drugs.com/newdrugs/fda-approves-pennsaid-topical-solution-1758.html
Pennsaid. NUVO