Inzululwazi emva kokuncediswa kwesi sondlo sesondlo ayisoloko isingqiniswanga
I-Osteoarthritis (OA) iyinto eqhelekileyo, ikhubaza izifo zamalungu, ezibangela iimpawu zentlungu, ubunzima, kunye nokuvuvukala, ngokukodwa emadolweni, emagqabini, emlonyeni, nangamalungu.
Indlela i-OA ikhula ngayo iyinkimbinkimbi kodwa ekugqibeleni ibandakanya ukutshabalalisa izicubu ezikhusela amathambo ekuxubeni ndawonye (le tissue ibizwa ngokuba yi- carticlage ).
Ukutshatyalaliswa kwezicubu kubangela ukukhula kwethambo, okwenzeka ukuba ngelinye ilanga kudala i-bone spurs kunye ne-joint shapen joints, ukuphazamisa ngakumbi umsebenzi wokudibanisa.
Ngenxa yeempawu, ngakumbi iintlungu, ezibangelwa yi-osteoarthritis, abantu abane-OA ngokwemvelo bafuna iindlela zokwelapha ezinokunciphisa intlungu yabo. Ukutya okuncedayo kudla ngokugqithiseleyo, ngokukodwa kwabo bangakwazi ukuthatha imithi ye-OA-easing medication njenge-antisteroidal anti-inflammories (NSAIDs).
Esinye isongezelelo sokutya sokuthi abanye abantu basebenzise ukuphatha i-OA yabo ibizwa ngokuba yi-SAM-e (S-adenosylmethionine).
Ukuqonda i-SAM-e
Unokumangaliswa ukuva ukuba i-SAM-e ifunyanwa ngokuqhelekileyo kwiiseli zomntu. Yenziwe kwi-amino acid ebizwa ngokuba yi-methionine kwaye idlala indima ekulawuleni iinkqubo ezithile ze-biochemical kwiiseli ezinjengokugcina iimbumba zeseli, ukususa izinto ezinobuthi ezivela emzimbeni, nokuvelisa iikhemikhali eziphucula imimoya.
Okuthakazelisayo kukuba, i-SAM-e yayifundwa ekuqaleni kwendima yayo ekudakaleni. Kwizifundo zoxinzelelo, abanye abathathi-nxaxheba kunye ne-OA baqaphele ukuphucula uphawu lokuhlanganyela emva kokuthatha i-SAM-e. Oku kwaqaliswa ukujongwa ngokuthe ngqo kwindlalifa ye-SAM-e njengenkululeko yokubuyisela intlungu kulabo abane-osteoarthritis.
Ngelishwa, iziphumo zophando kwi-SAM-e azizange zinike ubungqina obunamandla bokusebenza kwayo.
Enyanisweni, uphando lubonise ukuba kuthelekiswa ne-placebo, i-SAM-e ifana nokokunciphisa iimpawu zentlungu ehlobene ne-OA kunye nomsebenzi wenyama.
Xa kuthelekiswa nama-NSAID, uphando lubonisa ukuba abo bathatha i-SAM-e babenemiphumo efanayo kunye nokuphuculwa komsebenzi odibeneyo, nangona iziphumo zempembelelo zingaphantsi kwiqela le-SAM-e.
Ekugqibeleni, kwisifundo esincinci, esincinane ukuthelekisa i-1200mg ngosuku lwe-SAM-E kunye nama-200mg ngosuku lweCelebrex kwiiveki ezingama-16 (i-knee osteoarthritis), iCelebrex yabonisa ukunciphisa kakhulu intlungu kune-SAM-e ngenyanga yokuqala. Nangona kunjalo, akukho mfahluko omkhulu phakathi kwe-SAM-e neCelebrex ngenyanga yesibini.
Abaphandi beli phofu baphendule i-SAM-e yayilulaphule ukwenza, kodwa ngokuhamba kwexesha yayinempumelelo njengeCelebrex ekulawuleni i-osteoarthritis.
Iimiphumo ezimbi ezimbi ze-SAM-e
Njengamayeza amaninzi okanye amayeza, i-SAM-e ingakhokelela kwiimpawu ezinobungozi, nangona ezi ziqhelekileyo, kwaye zivame ukubonwa kwizinga eliphezulu. Le miphumo emibi ingabandakanya:
- I sizathu
- Flatulence
- Uhudo
- Ukuvutha
- Intloko
Ukongezelela, i-SAM-e inokusebenzisana nezinye izongezo zokutya okanye amayeza, njengama-antidepressants, i-L-tryptophan, okanye iSt. John's Wort. Yingakho kubaluleke kakhulu ukuxelela ugqirha wakho onke amayeza owathathayo, kubandakanywa nayiphi na imishanguzo.
Iingcaphephe zincoma nokuba ukhuphe i-SAM-e ukuba unesifo sengqondo sokugula okanye isifo sikaParkinson. Kwakhona, ukhuseleko lwe-SAM-e aluhloliswanga ngokukhulelwa okanye ukuncelisa, ngoko kufuneka kuphetshwe. Ekugqibeleni, kukho inkxalabo yokuba ukuthatha i-SAM-e kunokubangela ukutheleleka komswakama omkhulu (obizwa ngePneumocystis pneumonia okanye i-PCP) kubantu abanesistim somzimba sokubuthathaka, njengabantu abane-HIV.
ILizwi
Ukuba unayo i-osteoarthritis, kubalulekile ukuxoxa ngesicwangciso sonyango kunye nogqirha wakho. Okwangoku, akunakwenzeka ukuba i-SAM-e iya kuba yinxalenye yeso sicwangciso esekelwe ubungqina obungabonakaliyo kunye nobuncitshitshiweyo ukubuyisela inzuzo yayo.
Ngethemba, ngokuhamba kwexesha, zikhulu, ziza kwenziwa iingcaphephe ezenzelwe ukuba zenze ngcono ngakumbi indima ye-SAM-e kwi-OA unyango.
Nangona kunjalo, ungadangali, njengoko kukho iindlela ezininzi zokuncedisa ukuphucula ubuhlungu bakho be-OA nokuphucula umsebenzi wakho ohlanganyeneyo njengokulahleka kwesisindo (ukuba ukhuluphele okanye ukhuluphele), umzimba kunye nonyango lomzimba.
Iimpawu zigcinwe iimpawu ezinzima, njengoko zingatshintshi inkqubo yesifo. Amachiza aqhelekileyo asetyenziswa ukuphatha i-OA afaka:
- Ii-NSAID (zombini ngomlomo nakusesikhumba)
- ICapsaicin
- I-Cymbalta (duloxetine)
- I-Corticosteroids ijojowe kwindawo edibeneyo
> Imithombo:
> De Silva V et al. Ubu bungqina bokusebenza kwamachiza ancedisayo kunye namayeza ekulawuleni i-osteoarthritis: ukuhlaziywa okucwangcisiweyo. Rheumatology (Oxford). NgoMeyi ka-2011; 50 (5): 911-20.
> McAlindon > TE et al. Izikhokelo ze-OARSI zolawulo olungaphethiyo lwe-osteoarthritis. I-Osteoarthritis Cartilage . 2014 Mar; 22 (3): 363-88.
> Iziko leSizwe leMpilo eQinisiweyo kunye neNxulumene. (2017). I-S-Adenosyl-L-Methionine (SAMe): KwiNzulu.
> Rutjes AWS, Nüesch E, Reichenbach S, Jüni P. I-Adenosylmethionine ye-osteoarthritis yamadolo okanye i-hip. I-Cochrane Database yeeNkqubo eziPhononongo zika- 2009, Inkcazo 4. Ubugcisa. Inombolo: CD007321.
> SAM-e. (nd). Arthritis Foundation.