Iziganeko ezimbi ezinxulumene ne-Topical or Oral NSAID ezinganceda Unqume
Izidakamizwa ezichasayo ezingabhubhisiyo (i-NSAID) ziphakathi kweempawu eziqhelekileyo eziqhelekileyo ezichanekileyo ze- arthritis. Ii-NSAID zingathathwa ngomlomo ngendlela yamacwecwe, iifomsile okanye utywala. I-NSAID nazo ziyafumaneka kwi-formical formulation, njenge-cream, i-gel okanye i-liquid esebenzayo kwesikhumba.
Ii-NSAID ze-Topic zisebenza njani?
Ii-NSAID zeengqungquthela, ezifana ne-ibuprofen ye-topical okanye i- Voltaren gel , zisetyenziselwa ulusu ngaphezu kwesilwanyana esibuhlungu.
Kukho iinzuzo ezithile ezinxulumene ne-NSAID zengxelo ezibandakanya:
- ukuhanjiswa kweziyobisi ezichaphazelekayo
- kuncitshiswa kwimeko yeziphumo ezimbi ezinjenge-peptic isifo sesilonda kunye nokuphuma kwamanzi
Iingxelo ze-NSAID zengqungquthela zingena ngokukhawuleza, zihambisa imali encinci kwi-systemic circulation. Ukuthelekiswa ne-NSAID yomlomo, isicelo sesicatshulwa sikhokelela kwiziphumo eziphezulu ze-NSAID kwi-dermis (uluhlu lwesikhumba phantsi kwe-epidermis equkethe izicubu ezinxibelelwano). Ingqwalaselo ezuzwe kwiisisipha zesisipha ngaphantsi kwesiza sesicelo siyahluka, kodwa ubuncinane zilingana noko kuphunyezwe ngokulawulwa komlomo kwe-NSAID.
Iingxelo ze-NSAID zifikelela kwi- synovial fluid , kodwa zingaphi kwaye ziphi na iindlela ezichanekileyo. Ukwahlukana komntu ngamnye kwesikhumba kunokuthi ilandelelanise ukutshintsha okuthekileyo ekubonweni kwe-NSAID.
Ngokuqhelekileyo, kunzima ukubona ukuba i-NSAID yomlomo okanye yomlomo ingcono kuba iboniswe ukuba kwiimvavanyo zeclini kukho izinga eliphezulu le-placebo.
Abantu baxela inkululeko yentlungu nangona kungekho sithako esisebenzayo kwi pilisi okanye ukhilimu.
Ii-NSAID zomlomo zisebenza njani?
Ii-NSAID zomlomo ziipilisi, iifomsile okanye iyeza zamanzi ezigonywayo. Bawela kwinkqubo yokutya kwaye baxakeke kwigazi, baneziphumo kuwo wonke umzimba. Ii-NSAID zomlomo zisebenza ngokuvimbela i- cyclooxygenase (COX) , i-enzyme eyenza i-arachidonic acid i-prostaglandin kunye ne-leukotrienes.
I-Arachidonic acid ikhutshwe kwi-membrane phospholipids ekuphenduleni isenzo esibangelisayo. I-Prostaglandins isungula impendulo yokuvukela. Ii-SAs ziphazamisa ukuveliswa kwe-prostaglandines ngokuvimbela i-cyclooxygenase.
Ukwahlukana kwiZenzo eziMbi phakathi kwee-ORAL kunye neeNSAID zeengqungquthela
Iingxelo ze-NSAID zineengxelo zokhuseleko olungcono kunezo-NSAID zomlomo. Ukusetyenziswa kweziphumo ezincinci kwi-NIAID yokusetyenziswa kwimiba yezobugcisa kwenzeka ngo-10 ukuya ku-15% wezigulane kwaye zixutywa ngokukodwa (ukugqithisa kunye ne-pruritus - itching - apho i-NSAID yesicatshulwa yayisetyenziswa). Ukunyangwa kwezidakamizwa ezibi zesisu kunokunqabile nge-NSAID zemixholo, xa kuthelekiswa neziganeko ze-15% ezichazwe kwi-NSAID zomlomo.
Indlela iziguli ezikhetha ngayo phakathi kwee-ORAL kunye neeNSAID zeeNgqungquthela
Ukususela kwiingxelo ezimbini ezipapashwe kwiBritish Medical Journal (BMJ) , kwacaca ukuba isigqibo malunga nokuqulunqwa kwe-NSAID, ngomlomo okanye kwimixholo, kusetyenziswa ngokusekelwe kwi:
- isigulane sengqondo yomngcipheko wemiphumo emibi
- kubakho kwesinye isifo
- intlungu
- iingcebiso ezifunyenweyo
- ngokuqhelekileyo (indleko kunye nokulula ukusebenzisa)
Kwi- BMJ , abaphandi baphetha ngelithi "ii-NSAID zengqungquthela yindlela efanelekileyo, ekhuselekileyo kwi-NSAID yomlomo yokunyanga kwe- knee osteoarthritis , nokuba i-placebo effect ichaza ubuninzi bexabiso lala maqumrhu aphezulu."
Njengamaxesha onke, xubusha izinto ozikhethayo kunye nogqirha wakho kwaye usebenze kunye ukuze ufumene ukuba yiyiphi enye indlela enokukhetha ngayo imeko yakho kunye nemeko.
> Imithombo:
> Ii-NSAID ze-ORAL kwiimpawu ze-rheumatic: ukuthelekisa. Zi yobisi. 2000 Septemba; 60 (3): 555-74. Heyneman CA et al.
> I-Oral vs. NSAID yezobugcisa zeentlungu ze-OA - njani kwaye kutheni abantu bakhetha unyango. Disemba 5, 2007. > UKMiCentral >. NHS.