Isifo sikashukela kunye nokunyanga kwegazi zihlobene nezifo ezondla kunye kwaye zivame ukuba zibi nakwixesha. Ngokwendalo, ubudlelwane phakathi kwesifo sikashukela kunye nokunyuswa kwengcinezelo yegazi luhlobo lweempendulo zengxelo ezilungileyo, apho isinyathelo esinye sibangela isinyathelo sesibini kwaye isinyathelo sesibini "sondla emuva" ukuze senze enye inyathelo lokuqala.
Loop Feedback
Umzekelo osemgangathweni owenziwe kakuhle wobuhlobo bokuziqinisa phakathi kwesifo sikashukela kunye noxinzelelo lwegazi oluphezulu lwenzeka ezintsheni.
Iingongoma zibalulekileyo zexesha elide lomzimba wokulawula uxinzelelo lwegazi . Ngokulinganisa inani leetyuwa kunye ne-potassium emzimbeni, iintso zigqitywe ekugqibeleni ukulawulwa kohlobo oluthile lwamanzi njengomchamo. Lo msebenzi olawulayo omswelo unceda ukucwangcisa uxinzelelo lwegazi lwexesha elide ngokulawulwa ngokwasemzimbeni ukuba kunjani umbane kwimithambo yegazi. Ukuphumeza lo msebenzi kuxhomekeke ekuphumeni kwegazi kwizakhiwo ezinqabileyo ze-capillary ezibizwa ngokuba yi-glomeruli (yodwa: glomerulus). I-glomeruli yileyunithi yokucoca yeentso.
Amanqanaba aphezulu ashukela egazini anxulumene nesifo sesifo sikashukela, kunye nezo ziquka i-glomeruli. Ngoluhlu lwezinto ezinzima, ushukela olungaphezu kwegazi ngokwenene lenza ukuba iindonga zama-capillari zitshale kwaye, kwezinye iimeko, zihlaziye ngokupheleleyo. Nangona iinkqubo ezichanekileyo kule nkqubo zinzima kakhulu ukuxoxa ngokubanzi, umphumo wokugqibela kukuba i-glomeruli ibe yimbi, kwaye ikhohliswa ekubeni icinge ukuba ayifumana igazi elaneleyo.
Ngenxa yoko, iinjongo ziphendula ngokuphakamisa uxinzelelo lwegazi ukubuyisela igazi "eliqhelekileyo" ukuhamba nge-glomeruli. Ngenxa yokuba zonakaliswe, i-glomeruli ifuna ukunyuswa ngokusisigxina kwingcinezelo yegazi ukuze uqhubeke nokuhlunga igazi. Njengoko ixesha liqhubeka, ukuqhubela phambili kwesohlwayo ephezulu kukulimaza i-glomeruli ngaphezulu, okukhokelela ekunyusweni kwegazi okwandayo njengoko iintso zizama ukulungisa imeko.
Iimiphumo Zaso kwamanye amaqumrhu
Ezi mpembelelo zegazi ziphezulu ziye zaphazamiseka kwizinye iinkqubo zomzimba zomzimba, kubandakanywa izihlunu kunye neendawo zokufihla i-insulin yepascreas. Kwiimisipha, uxinzelelo oluphezulu lubangela imivenge yegazi ukuba ivumelwano. Ngenxa yoko, igazi elincinci ligeleza kwiindawo ezinkulu zomzimba zomzimba.
Oku kukhokelela ekunciphiseni ubukhulu beeseli zamascle kunye nokunciphisa inani leswekile leyo iiseli ezixhamla kwigazi. Ngenxa yokuba ushukela ongaphantsi luxutywa egazini, inqanaba leshukela elikhululekile egazini liphuma. Esi sishukela sikhululekile ekugqibeleni senza indlela yaso kwiintso, apho kubangela ukulimala komonakalo we-glomerular. Ukuguquka kwegazi okuphambukileyo kwi-pancreas, ngenxa ye-autorgulation, kunokukhokelela ekunciphiseni kwemveliso ye-insulin, ukuphakamisa iswekile yegazi kude.
Thintelo
Ngenxa yokuba isifo sikashukela kunye noxinzelelo oluphezulu lwegazi ziqina ngokuzimelela, kubaluleke kakhulu ukugcina ulawulo oluqinileyo lweeshukela zegazi kunye negazi. Ukuphakanyiswa kwezona zigulo ezinokubakho kwezi zimbini izifo zingakhokelela ngokukhawuleza kwisixa esiphezulu (isixa "esikhulisiweyo") somonakalo. Esi sizathu esiyinqobo sokuba iinjongo zokwelapha iswekile yegazi zinamandla ngakumbi ekusetyenzisweni kwengcinezelo ephezulu yegazi kunye neenjongo zonyango lwexinzelelo lwegazi zilungele ngakumbi kwisimo sesifo sikashukela.
Imithombo:
Ukulawulwa kwengcinezelo yegazi kunye nomngcipheko weengxaki ezinamandla kunye ne-microvascular kwi-type 2 yeswekile: UKPDS 38. UK Iqela eliFundekayo leSwekile le-UK. BMJ 1998; 317: 703.
I-K / DOQI Izikhokelo zoLwazi lweeNkcazo kunye neZikliniki zokuSebenza eziKliniki zengxaki yesifo sikashukela kunye nesifo sesifo esingasigxina. Ngaba iJ Kidney Dis 2007; 49 (iSiza 2): S17.
Jafar, TH, Stark, PC, Schmid, CH, et al. Ukuqhubela phambili kwesifo sesifo esingasasigxina: indima yokulawula uxinzelelo lwegazi, iproteinuria, kunye ne-angiotensin-ukuguqula i-enzyme inhibition: i-meta-analysis analysis level. U-Ann Intern Med 2003; 139: 244.
Buse, JB, Ginsberg, HN, Bakris, GL, et al. Uthintelo oluphambili lwezifo zengqondo kwiabantu abanesifo sikashukela: inkcazelo yesayensi evela kwi-American Heart Association kunye ne-American Diabetes Association. Ukuhamba ngo-2007; 115: 114.