Iziyobisi zivimbela i-HIV ukuba igxothise i-Cell Genetic Machinery
Ukwahlula
I-Vitekta (elvitegravir) yicirrheviral ekhethwe njenge- integrase inhibitor esetyenziselwa unyango lwe- HIV . I-Integrase inhibitors isebenza ngokuthintela i-enzyme ye-HIV ebizwa ngokuba yi-integrase, leyo i-HIV isebenzisayo ukudibanisa i-coding yayo kwi-DNA yeselula. Ngokuthintela integrase, intsholongwane ayikwazi ukugqiba umjikelo wayo wobomi kwaye idale ezinye ii-virions ze-HIV.
I-Vitekta yavunywa yi-US Food and Drug Administration (FDA) ngoSeptemba 2014 ukuze isebenzise abantu abadala ngaphambili babonelele unyango lwe-HIV.
I-Elvitegravir iyinxalenye yesigxina esilungisiweyo somnxeba iStribild (esaziwayo ngokubizwa ngokuba yi "Quad Pill") kunye nesibini sesizukulwana sesiStribild esibizwa ngokuthi nguGenvoya .
UkuPhathwa kweziMilo
I-Vitekta ifumaneka kwiifomathi ezimbini zeethebhulethi:
- I-85 mg i-pentagon eboyiweyo, iipilisi ezifakwe ifilimu, eluhlaza okombala kunye ne "GSI" emacaleni kwelinye icala kunye "85" kwelinye.
- I-150 mg yefomati eboyiweyo yecala, i-green color-colored nge "GSI" engxenyeni enye kunye "150" kwenye.
Isistim
I-Vitekta kufuneka isetyenziswe rhoqo kwiinkqubo zonyango kunye ne- HIV protease inhibitor (PI) kunye ne- Norvir (ritonavir) , i- agent "yokwandisa" eyenza ukuxilongwa kwezilwanyana ezihamba kunye negazi. I-Vitekta kufuneka ithathwe ngokutya.
Imilinganiselo ephakanyisiweyo iyahluka ngokukhetha izidakamizwa ngale ndlela:
| IVitekta | Umthamo weProtease Inhibitor | Umlinganiselo we-Norvir (ritonavir) |
| 85mg rhoqo ngosuku | Reyataz (atazanavir) 300mg kanye ngosuku | 100mg rhoqo ngosuku |
| 85mg rhoqo ngosuku | Kaletra (400mg lopinavir + 100 mg ritonavir) kabini imihla ngemihla | Akukho mfuneko yokuba i-ritonavir sele iqulethwe kwi-Kaletra |
| 150mg rhoqo ngosuku | I-Prezista (darunavir) 600mg kabini imihla ngemihla | 100mg kabini imihla ngemihla |
| 150mg rhoqo ngosuku | Lexiva (fosamprenavir) 700mg kabini imihla ngemihla | 100mg kabini imihla ngemihla |
| 150mg rhoqo ngosuku | Aptivus (tipranavir) 500mg kabini imihla ngemihla | 200mg kabini imihla ngemihla |
Iziphumo eziPhakathi
KwisiGaba III sesifundo sezonyango zomntu, ininzi yeziphumo zecala yeziyobisi ziye zafunyanwa kwizigulane ezithatha iVitekta. Iziganeko eziqhelekileyo, ezichazwe ubuncinane kwi-2% yabathathi-nxaxheba zibandakanya:
- Uhudo
- I sizathu
- Intloko
Iziphumo eziqhelekileyo ezichaphazelekayo ziquka intlungu yesisu, ukunyanzelisa, ukukhawuleza, ukukhathala nokuhlanza. Iziphumo eziqhelekileyo zivame ukuhamba ixesha elide, kwaye izigulana ezimbalwa ziyeka ngenxa yokunyamezela unyango.
Ukuchasana kweziyobisi
I-Vitekta akufanele ithatyathwe ngamachiza alandelayo okanye izongezelelo zemfuyo:
- Imithi ye-Hepatitis C: Invicek, Victrelis
- I-Rifampin-based based anti-tuberculosis: I-Rifater, i-Rifamate, i-Rimactane, i-Rifadin, i-Priftin (indawo ye-Mycobutin)
- ISt John's Wort
Njalo uxelele ugqirha wakho nasiphi na isilwanyana okanye isongezelelo, esimiselweyo okanye esingasimiselweyo, ukuba ungathatha ngaphambi kokuba uqalise nayiphi na unyango lwe-antiretroviral.
Ulwalamano lwe-Antiretroviral Drug
Ukusetyenziswa kweVitekta kunye nezidakamizwa ezilandelayo ze-antiretroviral kunokubangela ukuba kukho ukulahlekelwa yempembelelo yokwelapha yesilwanyana esilandelayo okanye ukwanda kweempembelelo:
- Sustiva (efavirenz) akufanele ilawulwe yi-Vitetkta.
- I-Viramune (i-nevirapine) akufanele ilawulwe yi-Vitekta.
- I-videx (didanosine) kufuneka ithathwe iyure enye ngaphambi kweyure okanye ezimbini emva kwe-Vitekta dose.
- I-Tybost (i-cobicistat), i-ejenti ekhuthazayo efana ne-Norvir, ayifanele ithathwe kunye ne-Vitekta xa ilawulwa yi-protease inhibitor.
Ezinye izinto
I-Antacids inokuthintela i-Vitekta ukuba ilandelwe kakuhle. Ukuba usebenzisa i-counter-counteracacid (umzekelo, i-Rolaids, i-Tums, i-Milk ye-Magnesia), kucetyiswa ukuba kuthathe iiyure ezimbini ngaphambi okanye emva kweDoloji yeVotaz.
Abafazi mabacebise ugqirha ukuba ngaba bathatha okanye baceba ukuthatha iipilisi zokulawula ukuzalwa. I-Vitekta, xa isetyenziswe ngeNorvir, inokunciphisa kakhulu ingxube ye-plasma ye- ethinyl estradiol / i- hormonal contraceptive.
Ezinye iindlela zokucetywa kwe-hormonal contraception zinconywa. Ungalokothi ukwandise ama-dosage ye-hormonal contraceptive. Kucetyiswa ukuba unina onomnyobisi angalusanga ukuba unesifo sengculaza njengoko kunokusasazela intsholongwane.
I-Vitekta iqukethe i-lactose ngoko qi niseka ukuba ucebise ugqirha wakho ukuba unayo i-lactose engavumiyo.
Imithombo:
US Administration and Drug Administration (FDA). "I- VITEKTA - UKUZIPHILA KWENGCACISO NGEZIBONELELO ." I-Silver Srpring, e-Maryland; fi kelele ngoFebruwari 3, 2015.
FDA. "I-FDA iyavuma ipilisi entsha yentsebenziswano ye-HIV kwezinye izigulane." Silver Spring, eMaryn; ukukhutshwa kwenkcazelo ekhutshwe ngomhla ka-Agasti 27, 2012.
KwiSayensi zeGiliyadi. " IGenvoya - eziPhambili zeNgcaciso yoLwazi." Foster City, California; fi kelelwa ngoDisemba 14, 2015.