UGenvoya ungumntu oyedwa-tablet, i-dose edibeneyo isilwanyana esisetyenzisiweyo kunyango lwe-HIV, elibandakanya izidakamizwa ezine ezahlukeneyo ze- antiretroviral :
- Elvitegravir , integrase inhibitor
- I-Cobicistat , i- HIV "booster" yeziyobisi
- Emtricitabine, i- nucleotide reverse transcriptase inhibitor (NtRTI)
- I-Tenofovir alafenamide (TAF), enye i-NtRTI
UGenvoya yipilisi yokuqala yokudibanisa ukusebenzisa i-TAF, inguqu "ephuculweyo" ye-tenofovir disoproxil fumarate (TDF) efunyenwe kwiziyobisi iTruvada , Atripla , kunye neComplera.
Ngaloo ndlela, kunokuqwalaselwa ukuphuculwa kwiStrive , ukwakheka kwethebhulethi enye kunye ne-elvitegravir + cobicistat + emtricitabine + TDF.
I-TAF ithathwa njengophezulu kwi-TDF njengoko inako ukuhambisa isilwanyana esisebenzayo ngokuthe ngempumelelo kwiiseli kunye nakwizinga elincinci kakhulu-kuthetha ukuba kukho ukwakhiwa okungaphantsi kwesilwanyana egazini kunye nelithuba elingaphantsi lokuvelisa iinjongo ezinxulumene neziyobisi. ezinetyhefu.
(Nangona ubungozi be-TDF-inxulumene neengxaki zesifo seengxaki kubonwa phantsi kumazwe athuthukile, loo mngcipheko ubonakala ukunyuka kakhulu kumazwe asathuthuka apho kukho iziganeko ezinkulu zentsholongwane ekhoyo ngaphambili.)
Inkcazo yokwelapha
UGenvoya uvunyiwe yi-US Food and Drug Administration ngomhla kaNovemba 5, 2015, ukuba isetyenziswe kubantu abadala kunye nabantwana abangaphezu kweminyaka eyi-12 abangakaze bafumane unyango lwe-HIV kwaye balinganise ngaphezu kwe-77 lbs (35 kgs). Ikwavunywa kwakhona kubantu abadala kwiyeza elinesigxina ngokupheleleyo (esingabonakaliyo).
UkuQulunqa
I-Genvoya yi-tablet ephihliweyo, ebomvu, ene-film, ene-150mg ye-elvitegravir, i-150mg ye-cobicistat, i-200mg ye-emtricitabine kunye ne-10mg ye-TAF. I-GSI "ngapha nangapha kunye ne" 510 "kwelinye.
Isistim
Elinye ithebhulethi ithathwa imihla ngemihla ngokutya. UGenvoya akufanele athathwe naliphi na isilwayo se-antiretroviral esisetyenziselwa ukuphatha i-HIV.
Imiphumela
Inani lezonyango ezichaphazelekayo ziye zaphawulwa kwizigulane zecilisi zecilnji ezithatha iGenvoya. Iziganeko eziqhelekileyo eziqhelekileyo, ezichazwe kwi-5% okanye ngaphezulu kwezigulane, zi:
- I sizathu
- Uhudo
- Ukukhathala
- Intloko
Imiphumo emibi yayivame ukuhamba, ixazululo malunga neeveki ezi-1-2, kunye nezigulana ezimbalwa ziyeka ngenxa yokunyanzelwana konyango.
Ukungqinelana
UGenvoya akufanele athathwe ngamachiza alandelayo okanye izongezelelo:
Iyeza-anti-migraine: I-Cafergot, i-Migergot, i-Ergostat, i-Ergotamine, i-Wigraine, i-Wigrettes, i-Ergotrate, i-Methergine, i-DHE 45
- Iyeza-antitictictic: I-Orap
- Izidakamizwa zokunciphisa i-Cholesterol: i-Zocor, i-Simcor, i-Vytorin, i-Mevacor, i-Advicor, i-Altoprev, i-Mevacor
- Imithi ye-Hepatitis B: i-Hepsera, Preveon
- Prokinetic agents: Propulsion, Propulsid Quicksolv
- Imithi yeprostate: Uroxatral
- Iipilonary hypertension medication: Revatio
- Imithi yokulwa nesifo sofuba: i-Mycobutin, iRifater, iRifamate, iRimactane, i-Rifadin, i-Priftin
- Iziqhelo: I-Versed, iHalcion
- ISt John's Wort
Ezinye izinto
I-Genvoya ayilunyanzelwanga kwizigulane ezinokukhubazeka kweengtso (ezichazwe njengento yokucwangciswa kokudalwa kwemveli engaphantsi kwe-30mL ngomzuzu). Nceda ugqirha ugqirha ukuba ngaba ukhona okanye uphathwa ngayo nayiphi na ingxaki yengqondo yomnye ugqirha.
UGenvoya akacebisikanga kwizigulane ezinobungozi benesibindi okanye abo abane- HTV B (HBV) abanokusuleleka kwintsholongwane engapheliyo njengokuba kunokunyusa kakhulu ingxaki yesibindi. Kucetyiswa ukuba abantu abane-HIV bahlolwe i-HBV ngaphambi kokumisela iGenvoya. Nceda ugqirha ugqirha ukuba unayo nayiphi na ingxaki yesibindi kunye / okanye imbali ye-hepatitis.
Imithombo:
US Food and Drug Administration. "I-FDA iyavuma unyango olutsha lwe-HIV." Silver Spring, eMaryn; ukukhutshwa kogcino ekhutshwe ngoNovemba 5, 2015.
KwiSayensi zeGiliyadi. "IGenvoya - eziPhambili zeNgcaciso yoLwazi." Foster City, California