Ukwahlula:
I-Tybost (i-cobicistat) isilwanyana esichazwa njenge-CYP3A inhibitor esetyenziswe kunyango lwe- HIV . UTybost usebenza ngokuthi "ukukhulisa" ukuxilongwa kwe-plasma ye-antiretroviral, i-Vitekta (elvitegravir), i- Reyataz (atazanavir) ne- Prezista (darunavir) , xa isetyenziselwa ukwelashwa kwe-antiretroviral (ipiriti) .
I-Tybost liyinxalenye yezidakamizwa ezinezidakamizwa ezichanekileyo zezilwanyana , iStrif (elvitegravir + cobicistat + tenofovir + emtricitabine) , i- Evotaz (i -anaanavir + cobicistat) kunye ne- Prezcobix (i-darunavir + cobicistat) ,
I-Tybost yavunywa yi-US Food and Drug Administration (i-FDA) ngoSeptemba 2014 kubabini abanezigulane nabasanda kuxilongwa abanesifo sengculaza.
Ifomu:
I-tablet ye-150mg ejikeleze ifilimu ejikeleze ifilimu, i-orange ekhanyayo kunye nombala kunye neencwadi "GSI" kwelinye icala.
Isixa:
Enye i-tablet 150mg ithathwa imihla ngemihla ngokutya ngexesha elifanayo njengoReyataz okanye i-Prezista. Ulwaphulo kufuneka lufake enye okanye ngaphezulu, ukuhamba kunye nezidakamizwa ze-antiretroviral (s).
Imiyalelo:
Ngaphambi kokuqala, izigulane zifanele zivavanywe ukuvavanya imvume yabo yokuqalwa kwama-creinine njengoko iTybost inokuphazamisa umsebenzi we-kidal (isney), ngokuqhelekileyo kwizigulane ezinobunzima bokungaziwayo okanye ukungafumaneki. Xa ilawulwa yi- Viread (tenofovir) -iziyobisi ziyaziwa ngokubangela ukukhubazeka kwe-renal kwezinye-kunconywa ukuba izigulane zivavanywe ngokusesikweni kwe-creinine imvume, i-urine glucose kunye neprotein yamanzi.
Iziphumo eziqhelekileyo:
KwiSigaba III sovavanyo lwezonyango zabantu, inani lezonyango ezichaphazelekayo ziye zachongwa xa usebenzisa iTybost.
Iziganeko eziqhelekileyo eziqhelekileyo, ezichazwe kwi-2% okanye ngaphantsi kwezigulane, zi:
- I-jaundice (ukuphuka kwesikhumba kunye namehlo)
- I-eycular icterus (ukuphuka kwamehlo)
- I sizathu
- Uhudo
Iziphumo eziqhelekileyo ezichaphazelekayo zibandakanya ukukhathala, intloko, ukulala, ukuhlanza kunye nentlungu ephezulu. Iigwegwe zamatye nazo zaphawulwa kwezinye izigulane xa uTybost wayephethe ulawulo kunye noReyataz kunye neViread, nangona iimeko zacatshangwa zinyameko kwaye azange ziphumelele unyango lokuyeka.
Ukuchasana kweziyobisi:
I-Tybost akufanele ithathwe ngamachiza alandelayo okanye izongezelelo zemfuyo:
- Amachiza olwaphulo-mthetho: i-Multaq
- Iyeza-anti-cholesterol: iMevacor, iZocor
- Iyeza-anti-gout: Uroxatral
- Amachiza e-anti-hypertension: I-Revatio
- Iyeza-antitictictic: Orap
- Imithi yonyango: iCamptosar, iCampto (xa ilawulwa nguReyataz)
- I-Ergot ene-anti-migraine derivatives: DHE 45, Ergotrate, Hydergine, Migrana
- I-Rifampin-based based anti-tuberculosis amayeza: Mycobutin, Rifater, Rifamate, Rimactane, Rifadin, Priftin
- Ukuzihlaziya: iDormicum, Halcion, Hypam, Hyponvel, Trilam, Versed
- ISt John's Wort
Ulwalamano lwe-Antiretroviral Drug:
Ukusetyenziswa kweTybost ngokulandela izidakamizwa ze-antiretroviral kunokubangelwa kukulahlekelwa yempembelelo yokwelapha yesilwanyana esikhoyo okanye ukwanda kweempembelelo:
- I-Crixivan (indinavir) akufanele ilawulwe nguTybost noReyataz.
- Intelence (etravirine) akufanele ilawulwe yiTybost.
- Sustiva (efavirenz) akufanele ilawulwe nguTybost no-Prezista.
- I-Viramune (i-nevirapine) akufanele ilawulwe nguTybost no-Prezista.
- Inqanaba le-Selzentry (maraviroc) kufuneka litshintshwe kwi-150mg kabini imihla ngemihla ukuba ilawulwa yiTybost.
Okunye ukusebenzisana okanye iingqwalasela:
- Yazisa ugqirha wakho nayiphi nayiphi na into eyaziwayo okanye enokubakholelwa yintlungu onokuyenza ngaphambi kokuba uqale iTybost.
- I-Antacids kunye ne-aluminium okanye i-magnesium hydroxide inokuthintela iTybost / Reyataz ukuba ilandelwe kakuhle. Ukuba usebenzisa i-counter-acacid counter (umzekelo, i-Rolaids, i-Tums, i-Milk ye-Magnesia), kucetyiswa ukuba kuthathwe iiyure ezimbini ngaphambi okanye emva kweDobost / Reyataz.
- I- 2- imvume yokumelana ne-acid (eg, iTagamet, i-Pepcid, i-Axid, i-Zantac) inokuthi ibambe ukuchithwa kweTybost / Reyataz. Kucetyiswa ukuba bathathwe kunye noTybost / Reyataz okanye, ngokunye, ihora ezili-10 phambi okanye emva kweDobost / Reyataz.
- Iproton pump inhibitors (umz., I-Losec, i-Prilosec, i-Prevacid, i-Nexium, i-Pariet) inokuthi ibambe ukuchithwa kweTybost / Reyataz. Kucetyiswa ukuba bathathwe iiyure ezingama-12 ngaphambi okanye emva kweDobost / Reyataz.
- I-Erectile i-dysfunction medication (i-Viagra, i-Levitra, i-Cialis) kufuneka isetyenziswe ngokuqaphela njengoko uTybost inokunyusa izinga lemiphumo emibi, kubandakanywa ukuphazamiseka okubonakalayo, ukuxhatshazwa, kunye nokuxhaswa (ukuhluma, ukunyanzelisa). Kunconywa ukuba i-Viagra isilinganisi iyancipha ibe ngaphezu kwama-25mg kwiiyure ezingama-48; Umthamo we-Levitra uyancipha ungabi ngaphezu kwama 2.5mg ngeeyure ezingama-72; kunye ne-Cialis isilinganisi sehla ukuba singabi ngaphezu kwe-10mg kwieyure ezingama-72.
Imithombo:
KwiSayensi zeGiliyadi. "ITybost (i-cobicistat) - INKQUBO YOKWENZA NGOKWENZA IINKCUKACHA." Foster City, California; fi kelele ngoFebruwari 3, 2015.