I-Prezcobix (i-darunavir + cobicistat) yinyango edibeneyo yokudibanisa i- antiretroviral usetyenziso kunyango lwe- HIV . Amacandelo amabini eziyobisi aqulethwe kwi-Prezcobix athengiswa ngabanye kwi-Prezista (darunavir) kunye noTybost (cobicistat) .
Iipilisi enye, ipilisi ehlanganiswe ngokubambisana inika lula, i-day-day dosing, kunye nenxalenye ye-cobicistat ngokuphucula ngokufanelekileyo nokugcinwa kwinkxalabo ye-plasma ye-Prezista emzimbeni.
I-Prezcobix yavunywa yi-US Food and Drug Administration (i-FDA) ngoJanuwari 2015 kubo bonke abatsha abanezigulane nabantu abadala abane-HIV-1.
Ifomu
Ithebhulethi egciniweyo enefilimu, ene-800mg ye-darunavir kunye ne-150mg ye-cobicistat, i-pink inombala kwaye ifakwe "TG" ngapha nangapha "800" kwenye.
Isistim
Elinye ithebhulethi ithathwa imihla ngemihla ngokutya. I-Prezcobix ayikwazi ukusetyenziswa yedwa kodwa kufuneka ithathwe ngokudibanisa neyodwa okanye ngaphezulu kwezidakamizwa ze-antiretroviral.
Imiyalelo
Ngaphambi kokuqala, izigulane zifanele zivavanywe ukuvavanya imvume yabo yokudalwa kwemveli njengokuba i-Prezcobix inokuphazamisa umsebenzi wentsholongwane (intsipho), kaninzi kwizigulane ezinezifo ezingasebenzi okanye ezingaxhamliyo. Xa ilawulwa yi- Viread (i-tenofovir) - isicatshulwa saziwa ngokubangela ukukhubazeka kwe-renal kwezinye-kunconywa ukuba izigulane zivavanywe kwisigxina se-creinine, imvume ye-urine, kunye neprotheni yomchamo.
Kukwacetyiswa ukuba izigulane ezinezigulane zonyango, ngokukodwa ezo zichazwe kwi- inhibitors ye-HIV , zinikezelwa ukuvavanywa kwezesifo ngaphambi kokuthatha i-Prezcobix. Ukuba ukuhlolwa kohlobo lwe-genotypic alufumaneki, i-Prezcobix kufuneka igwenywe nabani na owake wavezwa kwi-inhibitors ye-HIV.
Iziphumo eziPhakathi
KwisiGaba se-III sesifundo sezonyango, ininzi yeziphumo zecala yeziyobisi ziye zachongwa xa usebenzisa i-Prezcobix. Iziganeko eziqhelekileyo eziqhelekileyo, ezichazwe kwi-5% okanye ngaphantsi kwezigulane, zi:
- Uhudo
- I sizathu
- Rash
- Intloko
- Intlungu zesisu
- Ukuvutha
Ukuchasana kweziyobisi
I-Prezcobix akufanele ithatyathwe ngamachiza alandelayo okanye izilwanyana ezincedisayo:
- Iyeza-anti-anginal: Ranexa
- Amachiza olwaphulo-mthetho: i-Multaq
- Iyeza-anti-cholesterol: iMevacor, iZocor
- Iyeza-anti-gout: Uroxatral
- Amachiza e-anti-hypertension: I-Revatio
- Imithi ye-Antipsychotic: Latuda, Orap
- Imithi yonyango: iCamptosar, iCampto
- I-Ergot ene-anti-migraine derivatives: DHE 45, Ergotrate, Hydergine, Migranal
- I-Rifampin-based based anti-tuberculosis amayeza: Mycobutin, Rifater, Rifamate, Rimactane, Rifadin, Priftin
- Ukuzihlaziya: iDormicum, Halcion, Hypam, Hyponvel, Trilam, Versed
- ISt John's Wort
Ulwalamano lwe-Antiretroviral Drug
Ukusetyenziswa kwe-Prezcobix kunye nezidakamizwa ezilandelayo zezidakamizwa ezinokubangela ukuba kukho ukulahlekelwa yempembelelo yokwelapha yesilwanyana esikhoyo okanye umngcipheko ophezulu wemiphumo emibi:
- I-Crixivan (indinavir) akufanele ilawulwe yi-Prezcobix.
- I-Videx (didanosine) kufuneka ithathwe iyure enye ngaphambi kweyure enye emva kokuthatha i-Prezcobix.
- Intelence (etravirine) akufanele ilawulwe yi-Prezcobix.
- I-Viramune (i-nevirapine) akufanele ilawulwe yi-Prezcobix
- Umlinganiselo we-Selzentry (maraviroc) kufuneka uhlaziywe kwi-150mg kabini imihla ngemihla ukuba ulawulwa yi-Prezcobix.
Okunye ukusebenzisana okanye ukuqwalasela
- Yazisa ugqirha wakho nayiphi na into eyaziwayo okanye eyayikukrokrelayo (intso) imeko onokuyenza ngaphambi kokuba uqale i-Prezcobix.
- I-Erectile i-dysfunction medication (Viagra, Levitra, Cialis) kufuneka isetyenziswe ngokuqaphela njengoko iqela le-cobicistat e-Prezcobix linokunyusa izinga lemiphumo emibi, kubandakanywa ukuphazamiseka okubonakalayo, ukuxhatshazwa, kunye nokuxhaswa (ukuhluma, ukunyanzelisa). Kunconywa ukuba i-Viagra dosage iyancipha ibe ngaphezu kwama-25mg kwiiyure ezingama-48; Umthamo we-Levitra uyancipha ungabi ngaphezu kwama-2.5mg kwieyure ezingama-72, kwaye i-Cialis isilinganiso sehla singabi ngaphezu kwe-10mg kwieyure ezingama-72.
Imithombo:
Bristol-Myers Squibb. "PREZCOBIX - UKUZIPHATHA KWEENKCUKACHA." ENew York, eNew York