Abaphandi bachonga ingxaki ekwazi ukuqhubela phambili kwi-AIDS kwiminyaka emithathu
Nangona kungekho khosi ehleliweyo kwindlela i- HIV iqhubela ngayo kumntu omnye ukuya kwesinye, kukho iintlobo (ezichanekileyo) ezinxulumene nokuqhubela phambili ngokukhawuleza. Ezi zintlobo zibangelwa ukuguqulwa kwemfuyo eqhubela phambili kwindawo ethile, ngokuqhelekileyo isasazeka ngaphaya kwaloo mmandla ukuba ibe yinto ebalulekileyo-ukuba ayinjalo.
Uphando olupapashwe kwiphepha lezokwelapha u- EBioMedicine luchaze ukuba enye into ehlukeneyo iye yahlukaniswa eCuba, eyaziwayo ikhula ibe nguGawulayo kwiminyaka emithathu yokusuleleka kwintsholongwane-eyenza ngokuqinisekileyo inkcaso ekhuselekileyo echazwe ngokutsha.
Ngokombiko, abaphandi baseYunivesithi yaseLeuven eBelgium baye bachonga ngokuqinisekileyo ukuxhatshazwa njenge- CRF19 , uguquko oluthile olubhekiselele kwi-HIV oluneentlobo ezintathu ezihlukeneyo , i-A, D, kunye ne-G.
Xa i-HIV iqhubela phambili kwi-AIDS kwiminyaka emihlanu ukuya kweyishumi ngaphandle kwonyango, i-CRF19 ibonakala iqhubela phambili ngokukhawuleza ukuba ibekwe ngumngcipheko omkhulu wokugula nokufa ngaphambi kokuqala unyango .
Iziphumo zoFundo
Izigulane ezingama-70 zachongwa ngabaphandi njengenkqubela phambili ngokukhawuleza (RP), kubonisa ukuba ukuwa kwexesha elidlulileyo kwi- CD4 count kuya ngaphantsi kweeseli 200 / mL okanye kubonisa isimo sengcaciso echaza ingculaza (okanye zombini).
Ubudala obuphakathi kwezigulane zazingama-34, ngelixa inani le-CD4 eliqhelekileyo ngexesha lokuxilongwa lalingama-276 cells / mL. Ngokwahlukileyo, iqela elidibeneyo lezigulane ze-HIV ngaphandle kokuhluka kwe-CRF19 kunomlinganiselo we-CD4 ophakathi phakathi kwama-522 no-577 ngexesha lokuxilongwa.
Ngaphezu koko, inkqubela phambili ngokukhawuleza yayinentsholongwane kaGawulayo yentsholongwane ye-
Ngenxa yoko, izigulane eziqinisekisiweyo ze-CRF19 zinexesha eliphakathi kwe- seroconversion kunye ne-AIDS kuphela kwiminyaka eyi-1.4 kuphela xa kuthelekiswa neminyaka eyi-9.8 ngenxa yabalingani babo abangenabo i-CRF19.
Iinkcazo zokuqhubela phambili ngokukhawuleza
Abaphandi banakho ukukhupha ngaphandle kwezinto ezininzi ezinokuthi zichaze ukuqhubela phambili ngokukhawuleza kuGawulayo. Ngokwezibalo zabantu, kwakukho ngokumangalisa ukuqhubela phambili ngokukhawuleza kwabathathi-ntliziyo kunokuba baqhube phambili (49% vs28%). Ukongezelela, akukho nto eyahlukileyo ekuthengeni i-HIV ngemisebenzi yesondo (isondo, isondo).
Ngokusekelwe kwiziphumo zabo, abaphandi bakholelwa ukuba utshintsho olukhawulezayo kwintlobo ye-CRF19 luchaza le nto.
Ngokuqhelekileyo, kukho iindidi ezimbini ze-co-receptors ephezulu kumaseli egazi ezimhlophe avumela ukungena kwe-HIV kwiseli: CCR5 neCXCR4 . I-CCR5 yi-co-receptor esebenzisa i-HIV ngokubanzi kwintsholongwane yokuqala, ngelixa i-CXCR4 isetyenziselwa ukusuleleka kwintsholongwane kamva.
Ngohlobo lwe-CRF19, intsholongwane iyatshintsha ukusuka kwi-CCR5 ukuya kwiCXCR4 ngokukhawuleza ngakumbi kunezinye iintlobo ze-HIV . Ngokwenza njalo, ukuqhubela phambili kwesi sifo kuya kukhawuleza, okukhokelela ekuphuhlisweni kwexesha elide ngaphambi kokuba u-AIDS.
Ezi ziphumo ziza kufuna ukunyuka kwe-HIV kwiCuba, okwangoku i-0.2% (xa kuthelekiswa ne-0.9% e-US) kunye namawaka angama-6 000 angqinelanayo.
Yintoni ekubhekiselele kukuba, ngexesha eliqhelekileyo ukususela kwiintsholongwane ukuya kwi-diagnostic ukusuka kwiinyanga ezingama-37 ukuya kwiinyanga ezingama-55, iziphathamandla zempilo karhulumente ziyakwazi ukuchonga abantu abane-variant CRF19 ngokukhawuleza ukwenzela ukugcina ukusasazeka kwintsholongwane.
Nangona ii-alamu zempilo yoluntu sele ziphakanyisiwe nje, i-variant yahlukana eCuba kwangoko ngo-2005 kwaye mhlawumbi ivela kuMbindi Afrika, apho kwahlwayelwa khona iimeko kwiAngola, eBurkina Faso, Cameroon naseTogo.
Imithombo:
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