I-Complera - I-HIV Antiretroviral Information Information

by UJames Myhre noDennis Sifris, MD, ugqirha oqinisekisiweyo webhodi

I-Dxed Fixed Dose Bugs Ukunikezela Ngomhla Wemihla ngemihla, I-Pill Pill

Ukwahlula

I-Complera yi-one-tablet, isalathisi esisisigxina esibambisene nesilwanyana esisetyenzisiweyo kunyango lwe-HIV, enamalungu amathathu e- antiretroviral ahlukeneyo:

rilpivirine , i- non-nucleoside reverse transcriptase inhibitor (i-NNRTI)
emtricitabine, i- nucleotide reverse transcriptase inhibitor (NtRTI)
i-tenofovir disoproxil fumarate (TDF), enye i-NtRTI

I-Complera yamkelwe yi-US Food and Drug Administration (i-FDA) ngo-Agasti 10, 2011 ukuze isebenzise kubantu abadala kunye nabantwana abangaphezu kweminyaka eyi-12 abangakaze bafumane unyango lwe-HIV , abanomthamo we- viral of 100,000 / m okanye ngaphantsi , kwaye ulinganise amakhilogremu angama-77 (35kg) okanye ngaphezulu.

I-Complera ingasetyenziselwa ukubuyisela unyango lwangoku ukuba isigulane sinomthwalo ongenakulinganiswa wentsholongwane (

UkuQulunqa

I-Complera yi-pink, i-capsule, ene-film-coated tablet, ene-25mg ye-rilpivirine, i-200mg ye-emtricitabine kunye ne-300mg ye-TDF. I-GSI "ngapha nangapha kwaye iyacaca kwenye.

Isistim

Ithebhulethi nganye imihla ngemihla ithathwa ngokutya. I-Complera akufanele ithatyathwe nayo nayiphi na isilwayo se-antiretroviral esisetyenziselwa ukuphatha i-HIV.

Imiphumela

Ininzi yeziphumo zecala leziyobisi ziye zaphawulwa kwizigulane zecilisi zecilithathi ezithatha iComplera, ezona ziqhelekileyo zizo:

I sizathu
Intloko
Ukungabikho
Ukuxinezeleka

Imiphumo emibi yayidlulileyo, kwaye izigulana ezimbalwa ziyeka ngenxa yokunyamezela unyango.

Ukungqinelana

I-Complera akufanele ithathwe ngamachiza alandelayo okanye izibonelelo:

Amachiza anxamnye ne-Anti-convulsive: Tegretol, Trilepta, phenobarbital, phenytoin
Iyeza-anti-tuberculosis: i-Mycobutin, iRifater, i-Rifamate, i-Rimactane, i- Rifadin, i-Priftin

Iproton pump inhibitors (PPIs): Nexium, Kapidex, Dexilant, Prevacid, Losec, Prilosec, Protonix, Aciphex okanye nayiphina i-PPI
Iyeza le-Steroid: i-dexamethasone (nangona inokuthi ilawulwe kwimiba enye xa kuthethwa ngempilo)
ISt John's Wort

Njalo uxelele ugqirha wakho nasiphi na isilwanyana okanye isongezelelo, esimiselweyo okanye esingasimiselweyo, ukuba ungathatha ngaphambi kokuba uqalise nayiphi na unyango lwe-antiretroviral.

Ezinye izinto

I-Complera ayilunyanzelwanga kwizigulane ezinokukhubazeka kweengqondo (ezichazwe njengezibonelelo ezidalwe ngokudaliweyo ezingaphantsi kwama-30mL ngomzuzu). Nceda ugqirha ugqirha ukuba ngaba ukhona okanye uphathwa ngayo nayiphi na ingxaki yengqondo yomnye ugqirha.

I-Complera ayilunyanzelwanga kwizigulane ezinobungozi besibindi okanye abo abanesifo esingapheliyo sesifo se- hepatitis B (HBV) njengoko kunokunyanzelisa kakhulu ingxaki yesibindi. Kucetyiswa ukuba abantu abane-HIV bahlolwe i-HBV ngaphambi kokumisela iComplera. Nceda ucebise ugqirha wakho ukuba unayo nayiphi na ingxaki yesibindi kunye / okanye imbali ye-hepatitis.

Icandelo le-rilpivirine yeComplera linokubangela ukuphendulwa kwe-hypersensitivity kwinani elincinci lezigulane, ngokuqhelekileyo ngohlobo lokugqithisa, ukukhanya kweso ("iso lesinki"), ukuvuvukala ubuso, umkhuhlane okanye ezinye izimpendulo. Ngokuqhelekileyo, iimpendulo ze-hypersensitivity zikhona emva kweeveki ezi-1-6 emva kokuqala kweyeza. Mcebisa ugqirha wakho ngoko nangoko naziphi na iimpawu ezibonakalayo. Kwiimeko ezinzima, unyango luya kufuneka luyeke.

Uhlaziyo lweNyango

Ukuqulunqwa kwe-Complera entsha kuvunyiwe yi-FDA ngoMatshi 1, 2016, kuthengiswa phantsi kwegama elithi Odefsey . Ukuqulunqwa kwesi sitsha kufaka indawo yecandelo le-TDF kunye neziyobisi ezibizwa ngokuba yi-tenofovir alafenamide (TAF), ekugqibeleni kwayo ichazwa njenge-pro-drug.

Ngokungafani ne-TDF, i-TAF ayinayo isicatshulwa esisebenzayo kodwa isetyenziselwa umzimba wayo ukuyiguqulela kwifomu yayo esebenzayo. Ngaloo ndlela, isilwanyana sithunyelwa ngokuthe ngempumelelo kwiiseli eziphantsi kwee-doses eziphantsi, kunye ne-toxicity ephantsi kakhulu kweziyobisi (ngokukodwa ngokubhekiselele kwintliziyo ehambelana nokusetyenziswa kweTDF).

_Imithombo:

_{I-US Food and Drug Administration (FDA_. "Ukuvunyelwa kweComplera: i-emtricitabine / rilpivirine / i-tenofovir DF edibeneyo ye-dose inhlanganisela." I-Silver Srping, eMadorin; yakhutshwe ngo-Agasti 10, 2011.}

_{KwiSayensi zeGiliyadi.} _{"I-Complera - eziphambili ze-Information Information."} _{Foster City, California;} _{kufike ngoMatshi 18, 2016.}

_Reuters. _{"I-BRIEF - I-Scientific Sciences yaseGiliyadi ithi i-US FDA ivuma i-Odefsey" Yakhishwa ngo-Matshi 1, 2015.}